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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for SIRT1 (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA GO:0000183 chromatin silencing at rDNA IDA GO:0001542 ovulation from ovarian follicle IEA GO:0006260 DNA replication TAS GO:0006281 DNA repair TAS GO:0006342 chromatin silencing IEA GO:0006342 chromatin silencing TAS GO:0006343 establishment of chromatin silencing IDA GO:0006344 maintenance of chromatin silencing IMP GO:0006355 regulation of transcription, DNA-dependent IEA GO:0006364 rRNA processing IEA GO:0006471 protein ADP-ribosylation TAS GO:0006476 protein deacetylation IDA GO:0006476 protein deacetylation IEA GO:0006476 protein deacetylation IMP GO:0006642 triglyceride mobilization ISS GO:0006974 response to DNA damage stimulus IDA GO:0007275 multicellular organismal development IEA GO:0007283 spermatogenesis IEA GO:0007517 muscle organ development IEA GO:0007569 cell aging TAS GO:0009267 cellular response to starvation ISS GO:0016575 histone deacetylation IDA GO:0016575 histone deacetylation IEA GO:0018394 peptidyl-lysine acetylation IMP GO:0030154 cell differentiation IEA GO:0030308 negative regulation of cell growth IMP GO:0031937 positive regulation of chromatin silencing IMP GO:0032071 regulation of endodeoxyribonuclease activity IMP GO:0033158 regulation of protein import into nucleus, translocation IMP GO:0034339 regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor ISS GO:0034983 peptidyl-lysine deacetylation IDA GO:0042127 regulation of cell proliferation IMP GO:0042981 regulation of apoptosis ISS GO:0043066 negative regulation of apoptosis IMP GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity IDA GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity IMP GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator IDA GO:0044419 interspecies interaction between organisms IEA GO:0045599 negative regulation of fat cell differentiation ISS GO:0045739 positive regulation of DNA repair IMP GO:0045768 positive regulation of anti-apoptosis IMP GO:0045768 positive regulation of anti-apoptosis TAS GO:0045892 negative regulation of transcription, DNA-dependent IDA GO:0050872 white fat cell differentiation ISS GO:0051097 negative regulation of helicase activity IDA GO:0060766 negative regulation of androgen receptor signaling pathway IMP GO:0070301 cellular response to hydrogen peroxide IDA GO:0070932 histone H3 deacetylation IDA GO:0070932 histone H3 deacetylation IMP GO:0080134 regulation of response to stress IDA GO:2000655 negative regulation of cellular response to testosterone stimulus IMP cellular_component GO:0000790 nuclear chromatin IDA GO:0005634 nucleus IDA GO:0005634 nucleus IEA GO:0005635 nuclear envelope IDA GO:0005637 nuclear inner membrane IDA GO:0005654 nucleoplasm IDA GO:0005677 chromatin silencing complex IDA GO:0005719 nuclear euchromatin IDA GO:0005720 nuclear heterochromatin IDA GO:0005730 nucleolus IDA GO:0005737 cytoplasm IDA GO:0016605 PML body IDA GO:0033553 rDNA heterochromatin IDA molecular_function GO:0002039 p53 binding IPI GO:0003714 transcription corepressor activity IDA GO:0003714 transcription corepressor activity ISS GO:0003950 NAD+ ADP-ribosyltransferase activity TAS GO:0004407 histone deacetylase activity IDA GO:0005515 protein binding IPI GO:0008022 protein C-terminus binding IPI GO:0008270 zinc ion binding IEA GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides IEA GO:0017136 NAD-dependent histone deacetylase activity IDA GO:0017136 NAD-dependent histone deacetylase activity IEA GO:0019213 deacetylase activity IDA GO:0033558 protein deacetylase activity IDA GO:0034979 NAD-dependent protein deacetylase activity IDA GO:0034979 NAD-dependent protein deacetylase activity IMP GO:0042393 histone binding IPI GO:0042802 identical protein binding IPI GO:0043398 HLH domain binding IPI GO:0043425 bHLH transcription factor binding IPI GO:0046872 metal ion binding IEA GO:0046969 NAD-dependent histone deacetylase activity (H3-K9 specific) ISS GO:0051019 mitogen-activated protein kinase binding IPI GO:0070403 NAD+ binding IEA

Protein-protein interaction details for SIRT1 (Homo sapiens) (Information is obtained from BioGRID)

Not available