| Entrez gene ID | | 23411 |
| Official gene symbol | | SIRT1 |
| Full name | | sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae) |
| Aliases | | ,SIR2L1, |
| Gene summary | | This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants. [provided by RefSeq] |
| Location | | Chromosome: 10 Locus: 10q21.3 |
| Gene position | | 69644427 - 69678147 Map Viewer |
| Gene orientation | | plus |
| Gene size | | 33721 bp |
| Gene sequence |
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| OMIM ID | | 604479 |