| Entrez gene ID | | 6890 |
|
| Official gene symbol | | TAP1 |
|
| Full name | | transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) |
|
| Aliases | | ,ABC17,ABCB2,APT1,D6S114E,FLJ26666,FLJ41500,PSF1,RING4,TAP1*0102N,TAP1N, |
|
| Gene summary | | The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is involved in the pumping of degraded cytosolic peptides across the endoplasmic reticulum into the membrane-bound compartment where class I molecules assemble. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. [provided by RefSeq] |
|
| Location | | Chromosome: 6 Locus: 6p21.3 |
|
| Gene position | | 32821748 - 32812986 Map Viewer |
|
| Gene orientation | | minus |
|
| Gene size | | 8763 bp |
|
| Gene sequence |
| |
|
| OMIM ID | | 170260 |
|
|
|
