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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for Sirt1 (Mus musculus)
(Information is obtained from AmiGO)
IDTermEvidence
biological_process
GO:0000122negative regulation of transcription from RNA polymerase II promoterISO
GO:0000183chromatin silencing at rDNAISO
GO:0001542ovulation from ovarian follicleIMP
GO:0006343establishment of chromatin silencingISO
GO:0006344maintenance of chromatin silencingISO
GO:0006351transcription, DNA-dependentIEA
GO:0006355regulation of transcription, DNA-dependentIEA
GO:0006364rRNA processingIEA
GO:0006476protein deacetylationIDA
GO:0006476protein deacetylationISO
GO:0006642triglyceride mobilizationIMP
GO:0006915apoptosisIEA
GO:0006974response to DNA damage stimulusISO
GO:0007275multicellular organismal developmentIEA
GO:0007283spermatogenesisIMP
GO:0007517muscle organ developmentIEA
GO:0009267cellular response to starvationIMP
GO:0016575histone deacetylationIDA
GO:0016575histone deacetylationISO
GO:0018394peptidyl-lysine acetylationISO
GO:0030154cell differentiationIEA
GO:0030308negative regulation of cell growthISO
GO:0031937positive regulation of chromatin silencingISO
GO:0032071regulation of endodeoxyribonuclease activityISO
GO:0033158regulation of protein import into nucleus, translocationISO
GO:0034339regulation of transcription from RNA polymerase II promoter by nuclear hormone receptorIMP
GO:0034983peptidyl-lysine deacetylationISO
GO:0042127regulation of cell proliferationISO
GO:0042981regulation of apoptosisIMP
GO:0043066negative regulation of apoptosisISO
GO:0043433negative regulation of sequence-specific DNA binding transcription factor activityISO
GO:0043518negative regulation of DNA damage response, signal transduction by p53 class mediatorISO
GO:0045599negative regulation of fat cell differentiationIMP
GO:0045739positive regulation of DNA repairISO
GO:0045768positive regulation of anti-apoptosisISO
GO:0045892negative regulation of transcription, DNA-dependentIDA
GO:0045892negative regulation of transcription, DNA-dependentISO
GO:0050872white fat cell differentiationIMP
GO:0051097negative regulation of helicase activityISO
GO:0060766negative regulation of androgen receptor signaling pathwayISO
GO:0070301cellular response to hydrogen peroxideISO
GO:0070932histone H3 deacetylationISO
GO:0080134regulation of response to stressISO
GO:2000655negative regulation of cellular response to testosterone stimulusISO
cellular_component
GO:0000790nuclear chromatinISO
GO:0005634nucleusIDA
GO:0005634nucleusISO
GO:0005635nuclear envelopeISO
GO:0005637nuclear inner membraneISO
GO:0005654nucleoplasmISO
GO:0005677chromatin silencing complexISO
GO:0005719nuclear euchromatinISO
GO:0005720nuclear heterochromatinIDA
GO:0005720nuclear heterochromatinISO
GO:0005730nucleolusISO
GO:0005737cytoplasmISO
GO:0016605PML bodyISO
GO:0033553rDNA heterochromatinISO
molecular_function
GO:0002039p53 bindingIPI
GO:0002039p53 bindingISO
GO:0003714transcription corepressor activityIMP
GO:0003714transcription corepressor activityISO
GO:0004407histone deacetylase activityISO
GO:0005515protein bindingIPI
GO:0008022protein C-terminus bindingISO
GO:0008270zinc ion bindingIEA
GO:0016787hydrolase activityIEA
GO:0017136NAD-dependent histone deacetylase activityIDA
GO:0017136NAD-dependent histone deacetylase activityISA
GO:0017136NAD-dependent histone deacetylase activityISO
GO:0019213deacetylase activityIMP
GO:0019213deacetylase activityISO
GO:0019899enzyme bindingIPI
GO:0019904protein domain specific bindingIPI
GO:0033558protein deacetylase activityIDA
GO:0033558protein deacetylase activityISO
GO:0034979NAD-dependent protein deacetylase activityIDA
GO:0034979NAD-dependent protein deacetylase activityISO
GO:0042393histone bindingISO
GO:0042802identical protein bindingISO
GO:0043398HLH domain bindingISO
GO:0043425bHLH transcription factor bindingISO
GO:0046872metal ion bindingIEA
GO:0046969NAD-dependent histone deacetylase activity (H3-K9 specific)IDA
GO:0051019mitogen-activated protein kinase bindingISO
GO:0070403NAD+ bindingIEA

Protein-protein interaction details for Sirt1 (Mus musculus)
(Information is obtained from BioGRID)
Not available