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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for TP53 (Homo sapiens)
(Information is obtained from AmiGO)
IDTermEvidence
biological_process
GO:0000060protein import into nucleus, translocationIEA
GO:0000075cell cycle checkpointTAS
GO:0000122negative regulation of transcription from RNA polymerase II promoterIBA
GO:0000122negative regulation of transcription from RNA polymerase II promoterIDA
GO:0000122negative regulation of transcription from RNA polymerase II promoterIEA
GO:0000122negative regulation of transcription from RNA polymerase II promoterISS
GO:0000733DNA strand renaturationIDA
GO:0001701in utero embryonic developmentIEA
GO:0001756somitogenesisIEA
GO:0001836release of cytochrome c from mitochondriaIEA
GO:0002309T cell proliferation involved in immune responseIEA
GO:0002326B cell lineage commitmentIEA
GO:0002360T cell lineage commitmentIEA
GO:0006284base-excision repairTAS
GO:0006289nucleotide-excision repairIMP
GO:0006302double-strand break repairIEA
GO:0006351transcription, DNA-dependentIDA
GO:0006355regulation of transcription, DNA-dependentIDA
GO:0006461protein complex assemblyIDA
GO:0006915apoptosisIDA
GO:0006915apoptosisIEA
GO:0006917induction of apoptosisIEA
GO:0006974response to DNA damage stimulusIDA
GO:0006974response to DNA damage stimulusIEA
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestIEA
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestTAS
GO:0006978DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorIMP
GO:0006983ER overload responseIDA
GO:0007049cell cycleIEA
GO:0007050cell cycle arrestIDA
GO:0007050cell cycle arrestIMP
GO:0007265Ras protein signal transductionIEP
GO:0007275multicellular organismal developmentIMP
GO:0007369gastrulationIEA
GO:0007406negative regulation of neuroblast proliferationIEA
GO:0007417central nervous system developmentIEA
GO:0007569cell agingIMP
GO:0007596blood coagulationTAS
GO:0008104protein localizationIDA
GO:0008156negative regulation of DNA replicationIEA
GO:0008283cell proliferationTAS
GO:0008285negative regulation of cell proliferationISS
GO:0008340determination of adult lifespanIEA
GO:0008340determination of adult lifespanISS
GO:0008629induction of apoptosis by intracellular signalsTAS
GO:0008635activation of caspase activity by cytochrome cIDA
GO:0009303rRNA transcriptionIEA
GO:0009792embryo development ending in birth or egg hatchingIEA
GO:0010165response to X-rayIBA
GO:0010165response to X-rayIEA
GO:0010332response to gamma radiationIEA
GO:0010332response to gamma radiationIMP
GO:0030154cell differentiationTAS
GO:0030308negative regulation of cell growthIMP
GO:0030330DNA damage response, signal transduction by p53 class mediatorIDA
GO:0030330DNA damage response, signal transduction by p53 class mediatorIMP
GO:0030512negative regulation of transforming growth factor beta receptor signaling pathwayIEA
GO:0031065positive regulation of histone deacetylationIBA
GO:0031065positive regulation of histone deacetylationIEA
GO:0031571mitotic cell cycle G1/S transition DNA damage checkpointIEA
GO:0031571mitotic cell cycle G1/S transition DNA damage checkpointIMP
GO:0033077T cell differentiation in thymusIEA
GO:0034613cellular protein localizationIDA
GO:0034644cellular response to UVIBA
GO:0034644cellular response to UVIEA
GO:0035264multicellular organism growthIEA
GO:0035690cellular response to drugIEP
GO:0042149cellular response to glucose starvationIDA
GO:0042493response to drugIEA
GO:0042771DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosisIDA
GO:0042771DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosisIEA
GO:0042981regulation of apoptosisIDA
GO:0043066negative regulation of apoptosisIDA
GO:0043066negative regulation of apoptosisIEA
GO:0043525positive regulation of neuron apoptosisIBA
GO:0043525positive regulation of neuron apoptosisIEA
GO:0044419interspecies interaction between organismsIEA
GO:0045892negative regulation of transcription, DNA-dependentISS
GO:0045893positive regulation of transcription, DNA-dependentIDA
GO:0045893positive regulation of transcription, DNA-dependentIMP
GO:0045944positive regulation of transcription from RNA polymerase II promoterIDA
GO:0045944positive regulation of transcription from RNA polymerase II promoterIEA
GO:0046677response to antibioticIEP
GO:0046902regulation of mitochondrial membrane permeabilityIEA
GO:0046902regulation of mitochondrial membrane permeabilityTAS
GO:0048147negative regulation of fibroblast proliferationIEA
GO:0050731positive regulation of peptidyl-tyrosine phosphorylationIEA
GO:0050731positive regulation of peptidyl-tyrosine phosphorylationISS
GO:0051097negative regulation of helicase activityTAS
GO:0051262protein tetramerizationTAS
GO:0051276chromosome organizationIEA
GO:0051726regulation of cell cycleIEA
GO:0070245positive regulation of thymocyte apoptosisIEA
GO:0070245positive regulation of thymocyte apoptosisISS
GO:0071158positive regulation of cell cycle arrestIMP
GO:0071456cellular response to hypoxiaIEP
GO:0071479cellular response to ionizing radiationIMP
GO:0072332signal transduction by p53 class mediator resulting in induction of apoptosisIMP
GO:0090343positive regulation of cell agingIEA
GO:0090399replicative senescenceIMP
GO:0090403oxidative stress-induced premature senescenceIMP
GO:2000379positive regulation of reactive oxygen species metabolic processIMP
cellular_component
GO:0000785chromatinIBA
GO:0000790nuclear chromatinIDA
GO:0005626insoluble fractionIDA
GO:0005634nucleusIDA
GO:0005634nucleusIEA
GO:0005654nucleoplasmIDA
GO:0005654nucleoplasmTAS
GO:0005657replication forkIBA
GO:0005657replication forkIEA
GO:0005669transcription factor TFIID complexIDA
GO:0005730nucleolusIDA
GO:0005737cytoplasmIDA
GO:0005737cytoplasmIEA
GO:0005739mitochondrionIDA
GO:0005783endoplasmic reticulumIEA
GO:0005829cytosolIBA
GO:0005829cytosolIEA
GO:0016363nuclear matrixIDA
GO:0016604nuclear bodyIDA
GO:0016605PML bodyIDA
GO:0043234protein complexIDA
molecular_function
GO:0000739DNA strand annealing activityIDA
GO:0001085RNA polymerase II transcription factor bindingIPI
GO:0002020protease bindingIPI
GO:0002039p53 bindingIBA
GO:0003677DNA bindingIEA
GO:0003677DNA bindingIMP
GO:0003682chromatin bindingIDA
GO:0003682chromatin bindingIEA
GO:0003684damaged DNA bindingIBA
GO:0003700sequence-specific DNA binding transcription factor activityIDA
GO:0003700sequence-specific DNA binding transcription factor activityIEA
GO:0005507copper ion bindingIDA
GO:0005515protein bindingIPI
GO:0005524ATP bindingIDA
GO:0008134transcription factor bindingIPI
GO:0008270zinc ion bindingTAS
GO:0019899enzyme bindingIPI
GO:0019901protein kinase bindingIPI
GO:0031625ubiquitin protein ligase bindingIPI
GO:0035033histone deacetylase regulator activityIEA
GO:0035035histone acetyltransferase bindingIPI
GO:0042802identical protein bindingIPI
GO:0044212transcription regulatory region DNA bindingIDA
GO:0044212transcription regulatory region DNA bindingIEA
GO:0046872metal ion bindingIEA
GO:0046982protein heterodimerization activityIPI
GO:0047485protein N-terminus bindingIPI
GO:0051087chaperone bindingIPI
GO:0051721protein phosphatase 2A bindingIPI
GO:0070215MDM2 bindingIEA

Protein-protein interaction details for TP53 (Homo sapiens)
(Information is obtained from BioGRID)
Not available