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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for TLR4 (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0000187 activation of MAPK activity ISS GO:0001666 response to hypoxia IEA GO:0002224 toll-like receptor signaling pathway TAS GO:0002282 microglial cell activation involved in immune response IEA GO:0002537 nitric oxide production involved in inflammatory response IEA GO:0002755 MyD88-dependent toll-like receptor signaling pathway TAS GO:0002756 MyD88-independent toll-like receptor signaling pathway TAS GO:0002758 innate immune response-activating signal transduction IEA GO:0003009 skeletal muscle contraction IEA GO:0006955 immune response TAS GO:0006979 response to oxidative stress IEA GO:0007165 signal transduction IEA GO:0007249 I-kappaB kinase/NF-kappaB cascade TAS GO:0007252 I-kappaB phosphorylation IDA GO:0008063 Toll signaling pathway TAS GO:0009636 response to toxin IEA GO:0010572 positive regulation of platelet activation ISS GO:0014823 response to activity IEA GO:0016046 detection of fungus NAS GO:0016064 immunoglobulin mediated immune response IEA GO:0030890 positive regulation of B cell proliferation IEA GO:0031663 lipopolysaccharide-mediated signaling pathway IDA GO:0032496 response to lipopolysaccharide IC GO:0032496 response to lipopolysaccharide IDA GO:0032497 detection of lipopolysaccharide IDA GO:0032570 response to progesterone stimulus IEA GO:0032689 negative regulation of interferon-gamma production ISS GO:0032700 negative regulation of interleukin-17 production ISS GO:0032707 negative regulation of interleukin-23 production ISS GO:0032715 negative regulation of interleukin-6 production ISS GO:0032720 negative regulation of tumor necrosis factor production ISS GO:0032722 positive regulation of chemokine production IDA GO:0032727 positive regulation of interferon-alpha production ISS GO:0032728 positive regulation of interferon-beta production ISS GO:0032729 positive regulation of interferon-gamma production ISS GO:0032732 positive regulation of interleukin-1 production ISS GO:0032733 positive regulation of interleukin-10 production ISS GO:0032735 positive regulation of interleukin-12 production ISS GO:0032755 positive regulation of interleukin-6 production IDA GO:0032757 positive regulation of interleukin-8 production IDA GO:0032760 positive regulation of tumor necrosis factor production ISS GO:0032868 response to insulin stimulus IEA GO:0032874 positive regulation of stress-activated MAPK cascade IEA GO:0034130 toll-like receptor 1 signaling pathway TAS GO:0034134 toll-like receptor 2 signaling pathway TAS GO:0034142 toll-like receptor 4 signaling pathway TAS GO:0042088 T-helper 1 type immune response NAS GO:0042116 macrophage activation IMP GO:0042346 positive regulation of NF-kappaB import into nucleus IDA GO:0042535 positive regulation of tumor necrosis factor biosynthetic process IDA GO:0042742 defense response to bacterium TAS GO:0043065 positive regulation of apoptosis IEA GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB cascade IEA GO:0043388 positive regulation of DNA binding IEA GO:0045084 positive regulation of interleukin-12 biosynthetic process IDA GO:0045087 innate immune response TAS GO:0045348 positive regulation of MHC class II biosynthetic process IEA GO:0045359 positive regulation of interferon-beta biosynthetic process IEA GO:0045416 positive regulation of interleukin-8 biosynthetic process IDA GO:0045429 positive regulation of nitric oxide biosynthetic process IEA GO:0045471 response to ethanol IEA GO:0045671 negative regulation of osteoclast differentiation NAS GO:0045944 positive regulation of transcription from RNA polymerase II promoter ISS GO:0046330 positive regulation of JNK cascade IEA GO:0050729 positive regulation of inflammatory response IC GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IEA GO:0050829 defense response to Gram-negative bacterium IC GO:0051092 positive regulation of NF-kappaB transcription factor activity IDA GO:0051770 positive regulation of nitric-oxide synthase biosynthetic process ISS GO:0051930 regulation of sensory perception of pain IEA GO:0052033 pathogen-associated molecular pattern dependent induction by symbiont of host innate immunity IEA GO:0060729 intestinal epithelial structure maintenance ISS GO:0060907 positive regulation of macrophage cytokine production IEA GO:0070373 negative regulation of ERK1 and ERK2 cascade ISS GO:0070374 positive regulation of ERK1 and ERK2 cascade IEA GO:0070430 positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway IEA GO:0070434 positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway IEA GO:0070542 response to fatty acid IEA GO:0071222 cellular response to lipopolysaccharide ISS GO:0071223 cellular response to lipoteichoic acid IEA GO:0071260 cellular response to mechanical stimulus IEP cellular_component GO:0005737 cytoplasm IDA GO:0005886 plasma membrane IDA GO:0005886 plasma membrane TAS GO:0005887 integral to plasma membrane IDA GO:0009897 external side of plasma membrane IDA GO:0045121 membrane raft IEA GO:0046696 lipopolysaccharide receptor complex IDA GO:0048471 perinuclear region of cytoplasm IDA molecular_function GO:0001530 lipopolysaccharide binding IMP GO:0001530 lipopolysaccharide binding NAS GO:0001875 lipopolysaccharide receptor activity IDA GO:0004872 receptor activity IEA GO:0004888 transmembrane signaling receptor activity NAS GO:0005515 protein binding IPI GO:0043548 phosphatidylinositol 3-kinase binding IEA

Protein-protein interaction details for TLR4 (Homo sapiens) (Information is obtained from BioGRID)

Not available