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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for SMAD3 (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA GO:0000122 negative regulation of transcription from RNA polymerase II promoter IMP GO:0001501 skeletal system development IEA GO:0001657 ureteric bud development IEA GO:0001666 response to hypoxia IMP GO:0001701 in utero embryonic development IEA GO:0001707 mesoderm formation IEA GO:0001756 somitogenesis IEA GO:0001836 release of cytochrome c from mitochondria IEA GO:0001889 liver development IEA GO:0001933 negative regulation of protein phosphorylation IMP GO:0001947 heart looping IEA GO:0002076 osteoblast development IEA GO:0002520 immune system development IEA GO:0006351 transcription, DNA-dependent IDA GO:0006810 transport IDA GO:0006917 induction of apoptosis IMP GO:0006919 activation of caspase activity IMP GO:0006955 immune response IMP GO:0007050 cell cycle arrest IMP GO:0007179 transforming growth factor beta receptor signaling pathway IDA GO:0007179 transforming growth factor beta receptor signaling pathway IEA GO:0007179 transforming growth factor beta receptor signaling pathway TAS GO:0007183 SMAD protein complex assembly IDA GO:0007369 gastrulation IEA GO:0007492 endoderm development IEA GO:0008285 negative regulation of cell proliferation IEA GO:0008633 activation of pro-apoptotic gene products IEA GO:0009880 embryonic pattern specification IEA GO:0010694 positive regulation of alkaline phosphatase activity IEA GO:0010718 positive regulation of epithelial to mesenchymal transition IMP GO:0016202 regulation of striated muscle tissue development IEA GO:0017015 regulation of transforming growth factor beta receptor signaling pathway IEA GO:0017015 regulation of transforming growth factor beta receptor signaling pathway IMP GO:0019049 evasion of host defenses by virus IDA GO:0030308 negative regulation of cell growth IDA GO:0030335 positive regulation of cell migration IEA GO:0030501 positive regulation of bone mineralization IEA GO:0030878 thyroid gland development IEA GO:0031053 primary miRNA processing TAS GO:0032731 positive regulation of interleukin-1 beta production IEA GO:0032909 regulation of transforming growth factor beta2 production IMP GO:0032916 positive regulation of transforming growth factor beta3 production IEA GO:0035413 positive regulation of catenin import into nucleus IMP GO:0042060 wound healing TAS GO:0042110 T cell activation IEA GO:0042177 negative regulation of protein catabolic process IMP GO:0042993 positive regulation of transcription factor import into nucleus IDA GO:0043066 negative regulation of apoptosis IEA GO:0045216 cell-cell junction organization IMP GO:0045668 negative regulation of osteoblast differentiation IEA GO:0045893 positive regulation of transcription, DNA-dependent IDA GO:0045930 negative regulation of mitotic cell cycle IMP GO:0045944 positive regulation of transcription from RNA polymerase II promoter IDA GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA GO:0045944 positive regulation of transcription from RNA polymerase II promoter IMP GO:0048340 paraxial mesoderm morphogenesis IEA GO:0048589 developmental growth IEA GO:0048617 embryonic foregut morphogenesis IEA GO:0048701 embryonic cranial skeleton morphogenesis IEA GO:0050678 regulation of epithelial cell proliferation IEA GO:0050776 regulation of immune response IEA GO:0050821 protein stabilization IMP GO:0050927 positive regulation of positive chemotaxis IEA GO:0051098 regulation of binding IEA GO:0051496 positive regulation of stress fiber assembly IEA GO:0051894 positive regulation of focal adhesion assembly IEA GO:0060039 pericardium development IEA GO:0060290 transdifferentiation IEA GO:0070306 lens fiber cell differentiation IEA GO:0090263 positive regulation of canonical Wnt receptor signaling pathway IMP cellular_component GO:0005622 intracellular IEA GO:0005634 nucleus IDA GO:0005634 nucleus IEA GO:0005637 nuclear inner membrane IDA GO:0005654 nucleoplasm TAS GO:0005667 transcription factor complex IEA GO:0005737 cytoplasm IDA GO:0005737 cytoplasm IEA GO:0005829 cytosol TAS GO:0005886 plasma membrane IEA GO:0043235 receptor complex IMP GO:0071141 SMAD protein complex IDA molecular_function GO:0000987 core promoter proximal region sequence-specific DNA binding IDA GO:0000988 protein binding transcription factor activity IDA GO:0001102 RNA polymerase II activating transcription factor binding IPI GO:0003690 double-stranded DNA binding IEA GO:0003700 sequence-specific DNA binding transcription factor activity IDA GO:0003700 sequence-specific DNA binding transcription factor activity IEA GO:0003706 ligand-regulated transcription factor activity IEA GO:0005160 transforming growth factor beta receptor binding IPI GO:0005515 protein binding IPI GO:0005518 collagen binding IEA GO:0008013 beta-catenin binding IPI GO:0008134 transcription factor binding IEA GO:0008134 transcription factor binding IPI GO:0008270 zinc ion binding IDA GO:0019901 protein kinase binding IPI GO:0019902 phosphatase binding IPI GO:0030618 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity IDA GO:0031490 chromatin DNA binding IEA GO:0031625 ubiquitin protein ligase binding IPI GO:0042803 protein homodimerization activity IPI GO:0043565 sequence-specific DNA binding IDA GO:0043565 sequence-specific DNA binding IEA GO:0044212 transcription regulatory region DNA binding IDA GO:0046332 SMAD binding IEA GO:0046872 metal ion binding IEA GO:0070410 co-SMAD binding IPI GO:0070412 R-SMAD binding IPI

Protein-protein interaction details for SMAD3 (Homo sapiens) (Information is obtained from BioGRID)

Not available