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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for Tlr4 (Rattus norvegicus)
(Information is obtained from AmiGO)
IDTermEvidence
biological_process
GO:0000187activation of MAPK activityISO
GO:0001666response to hypoxiaIEP
GO:0002218activation of innate immune responseISO
GO:0002224toll-like receptor signaling pathwayIDA
GO:0002282microglial cell activation involved in immune responseIDA
GO:0002537nitric oxide production involved in inflammatory responseISO
GO:0002755MyD88-dependent toll-like receptor signaling pathwayIEA
GO:0002756MyD88-independent toll-like receptor signaling pathwayIEA
GO:0002758innate immune response-activating signal transductionIMP
GO:0003009skeletal muscle contractionIEP
GO:0006954inflammatory responseIEP
GO:0006979response to oxidative stressIMP
GO:0007165signal transductionIEA
GO:0007252I-kappaB phosphorylationIEA
GO:0007252I-kappaB phosphorylationISO
GO:0009617response to bacteriumISO
GO:0009636response to toxinIEP
GO:0010572positive regulation of platelet activationISO
GO:0014823response to activityIEP
GO:0016064immunoglobulin mediated immune responseIEP
GO:0030890positive regulation of B cell proliferationISO
GO:0031663lipopolysaccharide-mediated signaling pathwayISO
GO:0031663lipopolysaccharide-mediated signaling pathwayISS
GO:0032496response to lipopolysaccharideIDA
GO:0032496response to lipopolysaccharideIEP
GO:0032496response to lipopolysaccharideISO
GO:0032497detection of lipopolysaccharideISO
GO:0032497detection of lipopolysaccharideISS
GO:0032570response to progesterone stimulusIEP
GO:0032609interferon-gamma productionISO
GO:0032689negative regulation of interferon-gamma productionISO
GO:0032700negative regulation of interleukin-17 productionISO
GO:0032707negative regulation of interleukin-23 productionISO
GO:0032715negative regulation of interleukin-6 productionISO
GO:0032720negative regulation of tumor necrosis factor productionISO
GO:0032722positive regulation of chemokine productionIEA
GO:0032722positive regulation of chemokine productionISO
GO:0032727positive regulation of interferon-alpha productionISO
GO:0032728positive regulation of interferon-beta productionISO
GO:0032729positive regulation of interferon-gamma productionISO
GO:0032732positive regulation of interleukin-1 productionISO
GO:0032733positive regulation of interleukin-10 productionISO
GO:0032735positive regulation of interleukin-12 productionISO
GO:0032755positive regulation of interleukin-6 productionIEA
GO:0032755positive regulation of interleukin-6 productionISO
GO:0032757positive regulation of interleukin-8 productionIEA
GO:0032757positive regulation of interleukin-8 productionISO
GO:0032760positive regulation of tumor necrosis factor productionISO
GO:0032868response to insulin stimulusIEP
GO:0032874positive regulation of stress-activated MAPK cascadeISO
GO:0042116macrophage activationIEA
GO:0042116macrophage activationISO
GO:0042346positive regulation of NF-kappaB import into nucleusIEA
GO:0042346positive regulation of NF-kappaB import into nucleusISO
GO:0042535positive regulation of tumor necrosis factor biosynthetic processIEA
GO:0042535positive regulation of tumor necrosis factor biosynthetic processISO
GO:0042742defense response to bacteriumIDA
GO:0043065positive regulation of apoptosisIMP
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB cascadeISO
GO:0043388positive regulation of DNA bindingIMP
GO:0045084positive regulation of interleukin-12 biosynthetic processIEA
GO:0045084positive regulation of interleukin-12 biosynthetic processISO
GO:0045087innate immune responseTAS
GO:0045348positive regulation of MHC class II biosynthetic processISO
GO:0045359positive regulation of interferon-beta biosynthetic processISO
GO:0045416positive regulation of interleukin-8 biosynthetic processIEA
GO:0045416positive regulation of interleukin-8 biosynthetic processISO
GO:0045429positive regulation of nitric oxide biosynthetic processISO
GO:0045471response to ethanolIMP
GO:0045944positive regulation of transcription from RNA polymerase II promoterISO
GO:0046330positive regulation of JNK cascadeISO
GO:0050671positive regulation of lymphocyte proliferationISO
GO:0050727regulation of inflammatory responseISO
GO:0050729positive regulation of inflammatory responseIMP
GO:0050731positive regulation of peptidyl-tyrosine phosphorylationIDA
GO:0050829defense response to Gram-negative bacteriumISO
GO:0051091positive regulation of sequence-specific DNA binding transcription factor activityIMP
GO:0051092positive regulation of NF-kappaB transcription factor activityIMP
GO:0051092positive regulation of NF-kappaB transcription factor activityISO
GO:0051384response to glucocorticoid stimulusIEP
GO:0051770positive regulation of nitric-oxide synthase biosynthetic processISO
GO:0051930regulation of sensory perception of painIMP
GO:0052033pathogen-associated molecular pattern dependent induction by symbiont of host innate immunityIDA
GO:0060729intestinal epithelial structure maintenanceISO
GO:0060907positive regulation of macrophage cytokine productionISO
GO:0070373negative regulation of ERK1 and ERK2 cascadeISO
GO:0070374positive regulation of ERK1 and ERK2 cascadeISO
GO:0070430positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathwayISO
GO:0070434positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathwayISO
GO:0070542response to fatty acidIDA
GO:0071222cellular response to lipopolysaccharideISO
GO:0071223cellular response to lipoteichoic acidISO
GO:0071260cellular response to mechanical stimulusIEP
GO:0071260cellular response to mechanical stimulusISO
cellular_component
GO:0005737cytoplasmIDA
GO:0005737cytoplasmISO
GO:0005886plasma membraneIEA
GO:0005886plasma membraneISO
GO:0005887integral to plasma membraneISO
GO:0005887integral to plasma membraneTAS
GO:0009897external side of plasma membraneIEA
GO:0009897external side of plasma membraneISO
GO:0009986cell surfaceIDA
GO:0045121membrane raftIDA
GO:0046696lipopolysaccharide receptor complexISO
GO:0046696lipopolysaccharide receptor complexISS
GO:0048471perinuclear region of cytoplasmIEA
GO:0048471perinuclear region of cytoplasmISO
molecular_function
GO:0001530lipopolysaccharide bindingIDA
GO:0001530lipopolysaccharide bindingISO
GO:0001875lipopolysaccharide receptor activityISO
GO:0001875lipopolysaccharide receptor activityISS
GO:0004872receptor activityIDA
GO:0004872receptor activityTAS
GO:0004888transmembrane signaling receptor activityIEA
GO:0005515protein bindingIPI
GO:0043548phosphatidylinositol 3-kinase bindingIPI

Protein-protein interaction details for Tlr4 (Rattus norvegicus)
(Information is obtained from BioGRID)
Not available