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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for Smad3 (Rattus norvegicus) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0000122 negative regulation of transcription from RNA polymerase II promoter IMP GO:0000122 negative regulation of transcription from RNA polymerase II promoter ISO GO:0001501 skeletal system development IEA GO:0001501 skeletal system development ISO GO:0001649 osteoblast differentiation ISO GO:0001657 ureteric bud development IEA GO:0001666 response to hypoxia IEA GO:0001666 response to hypoxia ISO GO:0001701 in utero embryonic development IEA GO:0001701 in utero embryonic development ISO GO:0001707 mesoderm formation IEA GO:0001707 mesoderm formation ISO GO:0001756 somitogenesis IEA GO:0001756 somitogenesis ISO GO:0001836 release of cytochrome c from mitochondria IMP GO:0001889 liver development IEA GO:0001889 liver development ISO GO:0001933 negative regulation of protein phosphorylation IEA GO:0001933 negative regulation of protein phosphorylation ISO GO:0001947 heart looping IEA GO:0001947 heart looping ISO GO:0002076 osteoblast development IEA GO:0002076 osteoblast development ISO GO:0002520 immune system development IEA GO:0002520 immune system development ISO GO:0006351 transcription, DNA-dependent IDA GO:0006351 transcription, DNA-dependent ISO GO:0006810 transport IEA GO:0006810 transport ISO GO:0006917 induction of apoptosis IEA GO:0006917 induction of apoptosis ISO GO:0006919 activation of caspase activity IEA GO:0006919 activation of caspase activity ISO GO:0006955 immune response ISO GO:0007050 cell cycle arrest IEA GO:0007050 cell cycle arrest ISO GO:0007179 transforming growth factor beta receptor signaling pathway IMP GO:0007179 transforming growth factor beta receptor signaling pathway ISO GO:0007183 SMAD protein complex assembly IEA GO:0007183 SMAD protein complex assembly IPI GO:0007183 SMAD protein complex assembly ISO GO:0007369 gastrulation IEA GO:0007369 gastrulation ISO GO:0007492 endoderm development IEA GO:0007492 endoderm development ISO GO:0008285 negative regulation of cell proliferation IDA GO:0008633 activation of pro-apoptotic gene products IMP GO:0008637 apoptotic mitochondrial changes IMP GO:0009880 embryonic pattern specification IEA GO:0009880 embryonic pattern specification ISO GO:0010694 positive regulation of alkaline phosphatase activity IDA GO:0010718 positive regulation of epithelial to mesenchymal transition IEA GO:0010718 positive regulation of epithelial to mesenchymal transition ISO GO:0016202 regulation of striated muscle tissue development IEA GO:0016202 regulation of striated muscle tissue development ISO GO:0017015 regulation of transforming growth factor beta receptor signaling pathway IEA GO:0017015 regulation of transforming growth factor beta receptor signaling pathway ISO GO:0019049 evasion of host defenses by virus IEA GO:0019049 evasion of host defenses by virus ISO GO:0030308 negative regulation of cell growth IEA GO:0030308 negative regulation of cell growth ISO GO:0030335 positive regulation of cell migration IMP GO:0030501 positive regulation of bone mineralization IDA GO:0030878 thyroid gland development IEA GO:0030878 thyroid gland development ISO GO:0032731 positive regulation of interleukin-1 beta production IMP GO:0032909 regulation of transforming growth factor beta2 production IEA GO:0032909 regulation of transforming growth factor beta2 production ISO GO:0032916 positive regulation of transforming growth factor beta3 production IMP GO:0035413 positive regulation of catenin import into nucleus IEA GO:0035413 positive regulation of catenin import into nucleus ISO GO:0042110 T cell activation IEA GO:0042110 T cell activation ISO GO:0042177 negative regulation of protein catabolic process IEA GO:0042177 negative regulation of protein catabolic process ISO GO:0042993 positive regulation of transcription factor import into nucleus IEA GO:0042993 positive regulation of transcription factor import into nucleus ISO GO:0043066 negative regulation of apoptosis IDA GO:0045216 cell-cell junction organization IEA GO:0045216 cell-cell junction organization ISO GO:0045668 negative regulation of osteoblast differentiation IEA GO:0045668 negative regulation of osteoblast differentiation ISO GO:0045893 positive regulation of transcription, DNA-dependent ISO GO:0045930 negative regulation of mitotic cell cycle IEA GO:0045930 negative regulation of mitotic cell cycle ISO GO:0045944 positive regulation of transcription from RNA polymerase II promoter IDA GO:0045944 positive regulation of transcription from RNA polymerase II promoter IMP GO:0045944 positive regulation of transcription from RNA polymerase II promoter ISO GO:0048340 paraxial mesoderm morphogenesis IEA GO:0048340 paraxial mesoderm morphogenesis ISO GO:0048589 developmental growth IEA GO:0048589 developmental growth ISO GO:0048617 embryonic foregut morphogenesis IEA GO:0048617 embryonic foregut morphogenesis ISO GO:0048701 embryonic cranial skeleton morphogenesis IEA GO:0048701 embryonic cranial skeleton morphogenesis ISO GO:0050678 regulation of epithelial cell proliferation IEA GO:0050678 regulation of epithelial cell proliferation ISO GO:0050728 negative regulation of inflammatory response ISO GO:0050776 regulation of immune response IEA GO:0050776 regulation of immune response ISO GO:0050821 protein stabilization IEA GO:0050821 protein stabilization ISO GO:0050927 positive regulation of positive chemotaxis IDA GO:0051098 regulation of binding IEA GO:0051098 regulation of binding ISO GO:0051496 positive regulation of stress fiber assembly IDA GO:0051894 positive regulation of focal adhesion assembly IDA GO:0060039 pericardium development IEA GO:0060039 pericardium development ISO GO:0060290 transdifferentiation IDA GO:0061045 negative regulation of wound healing ISO GO:0070306 lens fiber cell differentiation IEA GO:0070306 lens fiber cell differentiation ISO GO:0090263 positive regulation of canonical Wnt receptor signaling pathway IEA GO:0090263 positive regulation of canonical Wnt receptor signaling pathway ISO cellular_component GO:0005622 intracellular IEA GO:0005634 nucleus IDA GO:0005634 nucleus ISO GO:0005637 nuclear inner membrane IEA GO:0005637 nuclear inner membrane ISO GO:0005654 nucleoplasm IEA GO:0005667 transcription factor complex IDA GO:0005737 cytoplasm IDA GO:0005737 cytoplasm ISO GO:0005829 cytosol IEA GO:0005886 plasma membrane IEA GO:0005886 plasma membrane ISO GO:0043234 protein complex IDA GO:0043235 receptor complex IEA GO:0043235 receptor complex ISO GO:0071141 SMAD protein complex ISO molecular_function GO:0000987 core promoter proximal region sequence-specific DNA binding ISO GO:0000988 protein binding transcription factor activity ISO GO:0001102 RNA polymerase II activating transcription factor binding IEA GO:0001102 RNA polymerase II activating transcription factor binding ISO GO:0003677 DNA binding IDA GO:0003690 double-stranded DNA binding IEA GO:0003690 double-stranded DNA binding ISO GO:0003700 sequence-specific DNA binding transcription factor activity IDA GO:0003700 sequence-specific DNA binding transcription factor activity ISO GO:0003706 ligand-regulated transcription factor activity IMP GO:0005160 transforming growth factor beta receptor binding IEA GO:0005160 transforming growth factor beta receptor binding ISO GO:0005515 protein binding IPI GO:0005518 collagen binding IEA GO:0005518 collagen binding ISO GO:0008013 beta-catenin binding IEA GO:0008013 beta-catenin binding ISO GO:0008134 transcription factor binding IDA GO:0008134 transcription factor binding IPI GO:0008134 transcription factor binding ISO GO:0008270 zinc ion binding ISO GO:0019901 protein kinase binding IEA GO:0019901 protein kinase binding ISO GO:0019902 phosphatase binding ISO GO:0030618 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity IEA GO:0030618 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity ISO GO:0031490 chromatin DNA binding ISO GO:0031625 ubiquitin protein ligase binding IEA GO:0031625 ubiquitin protein ligase binding ISO GO:0042803 protein homodimerization activity IEA GO:0042803 protein homodimerization activity ISO GO:0043565 sequence-specific DNA binding IDA GO:0043565 sequence-specific DNA binding ISO GO:0044212 transcription regulatory region DNA binding ISO GO:0046332 SMAD binding IPI GO:0046872 metal ion binding IEA GO:0070410 co-SMAD binding IEA GO:0070410 co-SMAD binding ISO GO:0070412 R-SMAD binding IEA GO:0070412 R-SMAD binding ISO

Protein-protein interaction details for Smad3 (Rattus norvegicus) (Information is obtained from BioGRID)

Not available