| Entrez gene ID | | 9968 |
| Official gene symbol | | MED12 |
| Full name | | mediator complex subunit 12 |
| Aliases | | ,ARC240,CAGH45,FGS1,HOPA,KIAA0192,OKS,OPA1,TNRC11,TRAP230, |
| Gene summary | | The initiation of transcription is controlled in part by a large protein assembly known as the preinitiation complex. A component of this preinitiation complex is a 1.2 MDa protein aggregate called Mediator. This Mediator component binds with a CDK8 subcomplex which contains the protein encoded by this gene, mediator complex subunit 12 (MED12), along with MED13, CDK8 kinase, and cyclin C. The CDK8 subcomplex modulates Mediator-polymerase II interactions and thereby regulates transcription initiation and reinitation rates. The MED12 protein is essential for activating CDK8 kinase. Defects in this gene cause X-linked Opitz-Kaveggia syndrome, also known as FG syndrome, and Lujan-Fryns syndrome. [provided by RefSeq] |
| Location | | Chromosome: X Locus: Xq13 |
| Gene position | | 70338406 - 70362304 Map Viewer |
| Gene orientation | | plus |
| Gene size | | 23899 bp |
| Gene sequence |
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| OMIM ID | | 300188 |
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