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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for MED12 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID9968
Official gene symbolMED12
Full namemediator complex subunit 12
Aliases,ARC240,CAGH45,FGS1,HOPA,KIAA0192,OKS,OPA1,TNRC11,TRAP230,
Gene summaryThe initiation of transcription is controlled in part by a large protein assembly known as the preinitiation complex. A component of this preinitiation complex is a 1.2 MDa protein aggregate called Mediator. This Mediator component binds with a CDK8 subcomplex which contains the protein encoded by this gene, mediator complex subunit 12 (MED12), along with MED13, CDK8 kinase, and cyclin C. The CDK8 subcomplex modulates Mediator-polymerase II interactions and thereby regulates transcription initiation and reinitation rates. The MED12 protein is essential for activating CDK8 kinase. Defects in this gene cause X-linked Opitz-Kaveggia syndrome, also known as FG syndrome, and Lujan-Fryns syndrome. [provided by RefSeq]
LocationChromosome: X   Locus: Xq13
Gene position70338406 - 70362304  Map Viewer
Gene orientationplus
Gene size23899 bp
Gene sequence
OMIM ID300188