| Entrez gene ID | | 9915 |
| Official gene symbol | | ARNT2 |
| Full name | | aryl-hydrocarbon receptor nuclear translocator 2 |
| Aliases | | ,KIAA0307,bHLHe1, |
| Gene summary | | This gene encodes a member of the basic-helix-loop-helix-Per-Arnt-Sim (bHLH-PAS) superfamily of transcription factors. The encoded protein acts as a partner for several sensor proteins of the bHLH-PAS family, forming heterodimers with the sensor proteins that bind regulatory DNA sequences in genes responsive to developmental and environmental stimuli. Under hypoxic conditions, the encoded protein complexes with hypoxia-inducible factor 1alpha in the nucleus and this complex binds to hypoxia-responsive elements in enhancers and promoters of oxygen-responsive genes. A highly similar protein in mouse forms functional complexes with both aryl hydrocarbon receptors and Single-minded proteins, suggesting addition roles for the encoded protein in the metabolism of xenobiotic compounds and the regulation of neurogenesis, respectively. [provided by RefSeq] |
| Location | | Chromosome: 15 Locus: 15q24 |
| Gene position | | 80696692 - 80890278 Map Viewer |
| Gene orientation | | plus |
| Gene size | | 193587 bp |
| Gene sequence |
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| OMIM ID | | 606036 |
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