| Entrez gene ID | | 9811 |
| Official gene symbol | | CTIF |
| Full name | | KIAA0427 |
| Aliases | | ,Gm672,KIAA0427, |
| Gene summary | | CTIF is a component of the CBP80 (NCBP1; MIM 600469)/CBP20 (NCBP2; MIM 605133) translation initiation complex that binds cotranscriptionally to the cap end of nascent mRNA. The CBP80/CBP20 complex is involved in a simultaneous editing and translation step that recognizes premature termination codons (PTCs) in mRNAs and directs PTC-containing mRNAs toward nonsense-mediated decay (NMD). On mRNAs without PTCs, the CBP80/CBP20 complex is replaced with cytoplasmic mRNA cap-binding proteins, including EIF4G (MIM 600495), and steady-state translation of the mRNAs resumes in the cytoplasm (Kim et al., 2009 [PubMed 19648179]).[supplied by OMIM] |
| Location | | Chromosome: 18 Locus: 18q21.1 |
| Gene position | | 46065427 - 46389588 Map Viewer |
| Gene orientation | | plus |
| Gene size | | 324162 bp |
| Gene sequence |
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| OMIM ID | | 613178 |
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