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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for MDC1 (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 9656 Official gene symbol MDC1 Full name mediator of DNA-damage checkpoint 1 Aliases ,DKFZp781A0122,KIAA0170,MGC166888,NFBD1, Gene summary The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci. [provided by RefSeq] Location Chromosome: 6   Locus: 6p21.3 Gene position 30685458 - 30667584  Map Viewer Gene orientation minus Gene size 17875 bp Gene sequence >MDC1:complement(2179653..2197527):Length=17875 CACCATGTCTAGGAGGACCGAGGAAAGGCGCTCTGGCCTTACCAGACACGTCGGACGTCT ATGACACAGCCCCTCTATCCGTTGCCGGCAGCTGGCGCCAGACTCTCTGGTCGCGGTTTG GAACTGCGCGGGAAGTGGGTGGTGGGCGGGCAAGCGGTAGTGGGTTGTCCCTTGGAGCTG CCCAATCGACGTGCATTATTCTGTTGGCGCACGGCGGCCTTCAATTACCGTCTCATTAAC TGATCTCAGCAGCCTGGGAGACACCACCTATTTGAACTCTAAGGGGGCGGGGCTTTGGGT GTGCCTCCGCTCGACTGGCTGCGGTTGTGAAAGACAGCGGCAGAAGCCAATCAGCAAATA AGCTCTTTTTCGGCACACGCAGTCGCTCCACCCGGGTCGCGACCGTTACTGGTGGCGCGC GCGGGGACTTAAAGTAGGTGAGTTCTAGGGGCCTGGCCCACGGCTCCCCGGGAGCCATCT TGGTTCCCCCAGAAGGCGGGAGGGGCGTACCTTGGGTGCGACTGGGCGGAGGTGACTTGG AAGTTCGCTTCTCGGACTGTAATACTCATCCTTACCTGGCGCCCCGCTCCGAGTTTAGGT ATGAAGACACAGGGAGACGTCGGGCCACAAGGGAACCCACTGAGGTGGGGACCAAAGATG GTGGCTCTTTGAATTGGAGCCAAGCGTGGTGGGCACCCGCTGAGTTGGCCTGTCATAAAG ACGGAGTTGACACTTTATCCATGGGGCATCCTACTTTCCCTACCTGTCAACAGTTTCCCT CTAGAGTGGCATATTTTCAGGTGAATTCCATTTATGCTATTTTCTTTCCATCTCATTTGT TCCTTCATCAGTAGGCTCGGTGATGAGCCTTCCCGAGGGCAGGGTCGATTTCATGTTTGG TTCACAGATGTATACCAAATACTTCAAACAGGTATACCATAACCATTGAATGAATATGAT GGACCCTAGGGGAAAGACACGGTTCCCCTAATCCAGTCCTGGAGGTGGGTGAGTGTGAAG GCAGAAATGGAAAGTAATGGTTACAATATAGCGAGAGATCTTAGAGTAAGCACAAATCCA TTGACCACTGTGGAACAGGCAGGATACACCAGGAACACGAGAAGGCAGGGAACACGCCAG GAAAGGGTTTGCTGAGAAAGTGACATTTGAGGCCGGGCGCGGTTGCTCACTGCTGTAATC CCAACACTTTGGGTGGCCAAGGTGGGCGGATCACCTGAGGTCAGGAGCTCGAGACCGTGG TGAAACCCCGTCTCTACTAAAAATACAAAAATTAGCCAGGCGTGATGCCGGGCGCCTGTA ATCCCAGCTGCTCGGGAGGCTGAGGCAGGAGAATCGCTTGAAGCCTGGAGGCAGAGGTTG CAGTGAGCCAAGATAGCACCACTGCAGTCCAGCCTGGACGACAGAGCGAGATTCCATCTC AAAAAAAAAAAAAAGAAAGAAAGTGACATTTGAACTGAATCTTAAAGGATGGTAGAAGTT GGACCAGAAAACTAGGTGGGAAAAAGCCAAGGAATTGGGCTAAGGCATGAAGATGTGGGA AGACAAGAACAGTGTGTTCGAAGACTGGGGAAAATGTCTGGCTGAACCATAGGCTTTTGC GGGCGAGGGGTAGGCGTTACAAGATGTGAAGTTCAGATCATGGAGGGTCTCGCTAAGGAG TTTAGATTTTATTCTGTGTGCACGAAAAACCATCAAGATTTTAGAGGAGAGACATCTGAG TGATTTGGGGCAAGTCTTAACCTTATATATGCTTATGTATGTTTCAAGGAGATCTGAAAA TCTTAACCCAGCTATGTTGCAGTTTCTTTATCTGAAGAAATGGAAGATAGTAATACTACT TTACAAGGTTCTTGTGAAGATTAAATGAGTCAGAGTCGATATAAAGTAATTAGAACAGTG CTTGACACATAGGAAGCTTCTATATATGTCATCTTTTATTATCATTTTTTGCAGTTGCAT CTGATCAAACTGAGGTGGTCTGGTAAAAGTATAAAAAGCATGGGCTAAAAAAGAAAGAAA AACAACGGGGCGCAGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGTGGGC GGATCACCCAAGGTCAAGAGTTCGAGTCCACCCTGGCCAATATGGCAAAACCCCATCTCT TCTAAAAATACAAAAATTAGCCAGGCATGGTGGCAGGTGCCTGTAATCTCAGCTACTTGG GAGGCTGAGGTGAGAGAATTGCTTGAAACCCGGGAGGCAGAGGTTGCCGTGGGCCCAAGA TCTTACCACTGCATGCCAGCCTGGGGAGCAGAACGAGACTCCATCACAAAAAAGAAAAAA ATGTTTTAAGTGCTTCAGAAGGTTAACAACAGAAAGATTGGTGGAAAGAGAAGCATCAAC GTTCATAATGATCCAGTTTACCCCCTAGTTTTCAGTCTGATAACTCTGATGCTGTTTGTG TGAACCAATAATGAGGATAATTGATAATGTGTATCCTTCCCAGATCATGGAGGACACCCA GGCTATTGACTGGGATGTTGAAGAAGAGGAGGAGACAGAGCAATCCAGTGAATCCTTGAG GTGTAACGTGGAGCCAGTAGGGCGGCTACATATCTTTAGTGGTGCCCATGGACCAGAAAA AGGTCAGAGGGTATTGGATGTTCAAGTATTGATATAGATCTTTTATTTTTGTGGTAAGGT ATTTGGAGGGTTGCAAGAAGCTTATGTATGTTTCAATGAGATGTGAATTTTTTTTTTTCA TGAATGGAAGAGATGGGGCCGATTGAGTTGATAGTTGCAGACTACTACCCTGGACTCACT GGAAGTGATTTTACTTTGATAAAAGAAAATTAAGAGATTGAAATGAAGCTGGGTGCAGTG ACTCACACCTGTAATTCCCGTGCTTTGAGAGGCCAAGGCAGAAGGATCACTTGAGACTAG GAGTTAGAGACCAGCCTGGGTAGCATAGCAAAACCCTGTCTCTACGAAAAATTTAAAAAT TAGCCAGGTGTGGTGGTTCATTTCACATCTGCAGTCCCACCTACTTGGGAGGCTGAGCCA GATGATCACTTGAACCCAAGAGTTCAAGATTGCACTGATCTATGATCATGACACTGCATT CTAGCCTGGGTGACAGAATGAGACCCTGTCTCAAAAAAAAAAAAAAAATCAAATAAAATC CAATTGTGTGCTCTGGAGATGGATGGTAGTGATGATTGCACAACAGTGTGAATGCACTTA ATGCCACTGAACTATACACTTAAAATTATTAAGGTGATACATTTTGTGTTATGTGTATTT TATAACAGTAAAAAAACATCCATTGTGGATGGATGGGGTATCGCATATACTCTTTCAGTG CCTAGATGTCCTAGGGCCTTTTATTTTTCTAATGCATATGGAGGCCTTGAGTGAGTAGTA GAGTACCTAATAGGCACTTTTTCCTAATGACAGGCCAGGACTCTGATCTTGGAGCTTATC TACCTCTCTAATTCTTAGATTTCCCACTACACCTCGGGAAGAATGTGGTAGGCCGAATGC CTGACTGCTCTGTGGCCCTGCCCTTTCCATCTATCTCCAAACAACATGCAGAGATTGAAA TCTTAGCCTGGGACAAGGCACCTATCCTCCGAGACTGTGGGAGCCTTAATGGTACTCAAA TCCTGAGACCTCCTAAGGTTTTGAGCCCTGGGGTGAGTCACCGTCTGAGGGACCAGGAAT TGATTCTCTTTGCTGACTTGCTCTGCCAGTACCATCGCCTGGATGTCTCTCTGCCCTTTG TCTCCCGGGGCCCTCTGACAGTAGAAGAGACACCCAGAGTACAGGGAGAAACTCAACCCC AGAGGCTTCTGTTGGCTGAGGACTCGGAGGAGGAAGTAGGTAAGTTTGTATATTGGCAGG GAGAATGAGGAGACAGGAATAATGAGTGTACAATTGTCAACTCATTCCTTTCTGTTCTTG ACAGATTTTCTTTCTGAAAGGCGTATGGTAAAAAAATCAAGGACCACATCTTCCTCTGTG ATAGTTCCAGAGAGGTGAGTGCCAAAGAGTCAGACACCTGAGTCTTCAAAATGAGGAAGA ACCAGGGGCTGGAGGATCAATCTCTAAAAGAGATGATTATCATGAGAGTTGGGGCTGGGG AACCATACATATTCATTCACTCAGCTGAATTTTTATGGAGCACATCTGATGTGCCAAGTG GAAAACAAATTGGAAACAGAAGAAGAAATATGCTACCTTGTGTCTCCCCTCAAGGAGCTC ACAGTTGAGTTGGGGTATCCCTTCCAGGGAAATAAATTCTATAGACTCTCTTTTCTTCCC TTCACAGTGATGAAGAGGGGCATTCCCCGGTCCTGGGCGGCCTTGGGCCGCCTTTTGCCT TCAATTTGAACAGTGACACAGATGTGGAAGAAGGTCAGCAACCAGCCACAGAGGAGGCCT CCTCAGCTGCCAGAAGAGGTGCCACTGTAGAGGCAAAGCAGTCTGAAGCTGAAGTTGTAA CTGAAATCCAGCTTGAAAAGGATCAGCCTTTAGTGAAGGAGAGGGACAATGATACAAAAG TCAAGAGGGGTGCAGGGAATGGGGTGGTTCCAGCTGGGGTGATTCTGGAGAGGAGCCAAC CTCCTGGAGAGGACAGTGACACAGATGTGGATGATGACAGCAGGCCTCCTGGAAGGCCAG CTGAGGTCCATTTGGAAAGGGCTCAGCCTTTTGGCTTCATCGACAGCGACACTGATGCGG AAGAAGAGAGGATCCCAGCAACCCCAGTTGTCATTCCTATGAAGAAGAGGAAGATCTTCC ATGGAGTAGGTACAAGGGGTCCTGGAGCACCAGGCCTGGCCCATCTGCAGGAGAGCCAGG CTGGTAGTGATACAGATGTGGAAGAAGGCAAGGCCCCACAGGCTGTCCCTCTGGAGAAAA GCCAAGCTTCCATGGTTATCAACAGCGATACAGATGACGAGGAAGAAGTCTCAGCAGCGC TGACTTTGGCACATCTGAAAGAGAGCCAGCCTGCTATATGGAACAGAGATGCAGAAGAGG ACATGCCCCAACGTGTGGTCCTTCTGCAGCGAAGCCAAACCACCACTGAGAGAGACAGTG ACACAGACGTGGAGGAGGAAGAGCTCCCAGTGGAAAATAGAGAAGCTGTCCTCAAGGATC ACACAAAGATTAGAGCCCTTGTTAGAGCACATTCAGAAAAGGACCAACCTCCTTTTGGGG ACAGTGATGACAGTGTGGAAGCAGATAAGAGCTCACCTGGGATCCACCTGGAGAGAAGCC AAGCCTCCACCACAGTGGACATCAACACACAAGTGGAGAAGGAAGTCCCGCCAGGGTCAG CCATTATACATATAAAGAAGCATCAGGTGTCTGTGGAGGGGACAAATCAAACAGATGTGA AAGCAGTTGGGGGACCAGCAAAGCTGCTTGTGGTATCTCTAGAGGAAGCCTGGCCTCTGC ATGGGGACTGTGAAACAGATGCAGAGGAGGGCACCTCCCTAACAGCCTCAGTAGTTGCAG ATGTAAGAAAGAGCCAGCTTCCAGCAGAAGGGGATGCTGGGGCAGAGTGGGCTGCAGCTG TTCTTAAGCAGGAGAGAGCTCATGAGGTGGGGGCCCAGGGTGGGCCACCTGTGGCACAAG TGGAGCAGGACCTCCCTATCTCAAGAGAGAACCTCACAGATCTGGTGGTGGACACAGACA CTCTAGGGGAATCCACCCAGCCACAGAGAGAGGGAGCCCAGGTCCCCACAGGAAGGGAGA GAGAACAACATGTGGGTGGGACCAAGGACTCTGAAGACAACTATGGTGGTAAGTGCTGGC CTTCCTTCCTTGACCTCTGAAATCAACCAGGGTTCTAACAGCTGGGGTTGGGGAGAGAAA GGTAGAGATTATTTAAGGAGTTTAGTGTCAGGTATGATTTTTGTTTTAAACTGTCTTATA TTCCTCCCCGACCAGATTCTGAAGATCTGGACCTACAAGCTACCCAGTGCTTTCTGGAGA ATCAGGGCCTGGAAGGTGAGGACTTCTGTGTTATTTGAATCCTGTACCAGTGGGAGCTGG GAGATTAGACTGGTGGTCCTTGAAGGGTAAAGGCTAGTATGGGTAGGGTAGGAGACCAGG AATGGAACCCTACAGTAGTATGGAGGAGATGAACTTAGGCCATCTTTTCCTGTACAGCAG TCCAGAGCATGGAGGATGAACCTACCCAGGCCTTCATGTTGACTCCACCCCAAGAGCTTG GCCCTTCCCATTGCAGCTTCCAGACAACAGGTATAAGAAACTCTTCCCTCCTCTGTGTCC CCAATTCTGCATTCTCTTTTTTTTCCTCTGTCACTCAGGCTGGATTACAGTGGTGCAGTC TCGGCTCACTGTAACCTCCGCCTCCCAGGCGGTTTCTCTTCCTTCAGCTTCCCAGGTAGC TGGGATTACAGCTGTCCATGACCATGCCTGGCTAATTTTTTGTATGTTTAGTAGAGACAG GGTTTCACCATGTTGGCCAGGCTGGTCACAAACTCCCGACCTCAAGTGATCCGCCTGCCT CGGCCTCCCAAAATGCTGGAATTGCAGGCGTAAGCCACTGCGCCCGGCCTGCGTTCTTTC TTGATTTGCCTTCCTACATGTTTCTTTCATACTCTGATTACAGTGAGCCCTCTGTGTATG CGAGTTTGCGTCCGTGAATTCAACCAGCTGCAGGTTGAAAATATTTAGGGACTGGCCTGG GCAACAGAGAGAGACCTGGTCTCCACAAAAATGAAAAAATTAGCCCAGCATAGTAGTGAG CACCTGTAGTCCCAGTTACATGGGAGGCCAGGATGGGAAGATCAGTTGAGCCCAGTCTGG GCAATAGCCCATCCCTCAACCCCCACCCCCAATGTCTCTTAAAAAAAACACACACACACT ATTGCAGCACTGTTCACAATAGGCAGATATGAAATCAAACTAAATGTCCATCAACAGATG AATGGATAAAGAAAATGTAGGCCGGGGTCGGGCACAGTGGCTCACACCTCTAATCCCAAC ACTTTGGGAGGCCAAGGCAGGCAGATCACCTGAGATCGGGAGCTTGAGACCAGCCTGACC AACATGGAGAAACCCCGTCTCTACTAAAAATACAAAATTAGCCGGGTGTGGTGGTGCATG CCTGTAATCCCAGCTACTCAGGAGACTGAGTCAGGAGAATCCCTTGAACCCAGGAGGCAG AGGTTGCAGTGAGCTGAGATTGTGCCATCGCACTCTGGCCTGGGCAACAAGAGTGAAACT CTGTCTCAAAAAAACGAAAGAAAAGAAAATGTAGGCCGGGCACAGTGCCTCATGCCTGTA ATCCCAGCACTTTGGGAAGCCGAAGTGGGTGGATCACATGAGGTCAGGAGTTTGAGACCA GCCTGGCCAACATGGTGAAACCCTGTCTCTACTAAAAATACAAAAATTAGCTGGGCATGG TGGCAGGTGCCTGTAGTCCCAGCTACTCGGGAGACTGAAGCAGGAGACTCATTTGAACCC CGGAGGCAGAGGTTGCAGTGAGCCAAGGTCACACCACTGCACTCCAACATGGGCAACAGA GTGAGACTTCATCTCTAATAATAAAAAAAAAGAAAATGTGTATATAGGCTGGGTGCAGTG GCTCAAAATACAAAATTTAGCTGGGCATGGTGGCATGCACCTGTAGTCTTAGCTACTCGG GAGGCTAAGATGGGAGGATTGCTGCCTAAGACGCAGAGGTTGCAGTGAGCTGAGGTCATG CCACTGCACTCCAAACTGGGTGACAGAGCAAGACTCAATCTAAAAAAAAAAGAAAATGTG TATATATACACAGTGGAACAGTATTCAGCAACAGAAGAGAATGAAATCCTGTCATCTGCA GCAACATGGATGAACCCTGAGGACATTATGTTAAGTGAAATAAGTCAGCACAGAAAGGCA AATATTGTATGCTCACTCATGTGGGAGCTAAAAACATGGATCTCATGGAAGTAGAGAGTA GAATGGTGGTTACCAAAGGCTAGGAAGGGTAGAGGGACAGAATGCATAAAGAGGTTGGTT AATGAATACAAAAATCCAGTCAGATTGAATGAATAAGTTCTAGTGTTCAGTTCCACAGTA GTGTTACTATAGTTAATAATTTATTGTGTATTTCAAAATAGCTAGAAGAGATTTGATATG TTTCCAAGACAAAGAAATGATAAATGTTTGAGATAGTGGATATCCCAATTATCTTGGTTT TATCATTGTACATTGTATGCATGAGTCAAAATAGCACAGGTACCCCATAAATATGTACAA TTATTATGTGTCAATGAAGAAAAAAGAAAATGTGGTATATATACACAGTGGAATACTATT CAGCCTTTAAAAAGAAGGAAATTCCAGCCAAGCATGGTGGCTCACACCTGTAATCCCAGC ACTTTGGGAGACCAATGTGGGTGGATCACTTGAGTCTAAGAGTTCAAGACCAAACCCCAT CTCTACAACAAATACAAAAAATTAGCCGGGCACTTTGGCACATGCCGTAGTCCCAGCTAC TTGGGAGGCTGAGGTGGGAGGATCTCCTGAGCCCAGCAGTTGGGAGTTGCAGTGAGCCAA CATCATGCCACTGCACTCCAGCCTGGGTGACAGAGTGAAACTGTCTTGAGAGAGAGAGAC TATTCAGGGAACTCTCTTATTAGGCTATGATGTTTTTCTTTCTTTCTTTCTTTCTTTCTT TTTTTGAGACAGGGTCTCTGTCACTCAGGCTGGAATGCAGTGGTATGATGAGAGACTATT CAGGGAACTCATATTAGGCTATGATGTTTTTCTTTTTCTCTTGGGTTTTTTTTTTTTTTT TTTTTTGAGACAGAGTCTCTGTCACTCAGGCTGAAGTGCAGTGGTATGATCACAGCTCAC TACAGTCTTGACCTTTGGGGTTCAAGTAGTTCTCCTACCTCAGCCTCCCGGGTAGCTGAG ACTACAGGACTACAGGTCCCCGTCCCCACACCTAATTTTTTTGTATTTTTTGTAGAGATG GGGTTTTGCCATGTTGTCCAGGCTAGTCTCAAACTCCTGGCCTCAAGCAATCCTCATGTC TTGGCCTCCCAAAGTCCTGGGATTACATGTCTGAGCCACCATGCCCGCCTAAGGCTATGA CCTTTTTGAGACAAACGTTAAATGTTATAACTACCACCCTTATTCCCAGCTTACCTTTAA TAACCTGTTCAGATTTATTATTCATGAGTTTATCTAAATCCTTTCTCATCATATTTATTA TGTCAACCTGTACTTCCCTTTCCCTCTTCCTCTCCCTCTTTTCTCTCCCTCTCCCTCTCT CTCTCTTCCTTCCTCCCCTTCCAGGTACCCTAGATGAACCATGGGAGGTCCTGGCTACAC AGCCATTCTGTCTGAGAGAGTCTGAGGACTCTGAGACCCAGCCTTTTGACACGCACCTTG AGGCCTATGGACCTTGCCTGTCTCCACCTAGGGCAATACCAGGAGACCAACATCCAGAGA GCCCAGTTCACACAGAGCCAATGGGGATTCAAGGCAGAGGGAGGCAGACTGTGGATAAAG TCATGGGTATACCAAAAGAAACAGCAGAGAGGGTGGGCCCTGAGAGAGGGCCATTGGAGA GAGAAACTGAGAAACTGCTACCAGAAAGACAGACAGATGTGACAGGAGAGGAAGAATTAA CCAAGGGGAAACAGGACAGAGAACAAAAACAGTTGTTAGCTAGAGACACCCAGAGACAAG AATCTGACAAAAATGGGGAAAGTGCAAGTCCTGAAAGAGATAGGGAGAGTTTGAAGGTAG AAATTGAGACATCTGAGGAAATACAAGAGAAACAAGTACAGAAGCAGACCCTTCCAAGCA AAGCATTTGAGAGAGAAGTAGAGAGACCAGTAGCAAACAGAGAGTGCGATCCAGCCGAGT TAGAAGAGAAGGTGCCCAAAGTGATCCTGGAGAGAGATACACAGAGAGGGGAGCCAGAGG GAGGGAGCCAGGACCAGAAAGGGCAGGCCTCCAGCCCAACACCAGAGCCTGGGGTGGGGG CGGGGGACCTTCCGGGACCTACCTCAGCCCCCGTACCTTCTGGGAGCCAGTCAGGTGGAA GGGGATCCCCAGTGAGCCCCAGGAGGCATCAGAAAGGTAAGTGAAGGCAGAGGGGAACCC AAGGTGATACACAGGCCTCGTGATAATCAACCCCTGGGCAACCAGCTGCTTGGAACTCAG CCACCTTTGTGTTTACTTTCTGTCTAGGCCTCCTGAATTGCAAGATGCCACCTGCTGAGA AGGCTTCCAGGATCAGAGCTGCTGAGAAGGTTTCCAGGGTGAGAGCTACTTTTTCTACCT CCTATTCCACAAGTCATCTCTATATCTTCTCCAATGCTCTTTCACCTAGCCTCACTTTAA TCTATTCCTTTCTCATTATTCAGTTTTCTTCCATTTTTGTCACGCCTTGATTGGCTTCTA TTCCTTTATCCTCGGCACCCGTTGTTTTCCATATCTGTTTCCTAAGTTGTATCTCCTACC TGACTCAAAAGAAAGACCCTTCGTGTTTCTTCTTTCTTTGCCCCAGCCATCCTTTTCCTT ACCATCATCCACGTGTGGAGAACACTATAGTAGCATTATGGAGACAGGTCTGTGGGAAAA AGGTAGCTTCCCAGGTAGATCCCAGTCTAATGGAGGAGAGATCATAGACAGAAAGGAAAA TCCAGTGAGCATATTTTTTGTTTTTGTTCTTTTTTGAGACAGAGTCTGTCTCTGTCACCC AGGCTGGAGTGTGCAGTGGCGTGATCTCAGCTTACTGTAACCTCCGTCTCTTGGGTTCAA ACAATTTTCCTGCCGCAGCCTCCCAAGTAGCTGGGACTACAGGCGCATGTCACCCGGCTA ATTTTTGTGTATTTTTTTGTTTTTTTTGAGACAGTCTCACTCTGTCACCCAGGCTGGAGT GCAGTGGCGCGATCTTGGCTCACTGCAACCTCTGCCTCCCGGGTTCAAGCGACTCTCCTC CCTCAGCCTCCCAGGTAGCTGGGACTACTAGGCGCCTGCCAACACACCTAGCTAATTTTT TTTTTTTTTTTTTTTTTTTTAGACAGAGTCTTGCTCTGTCCCCCAGGCTGGAGTGCAGTG GCACCATCTCGGCTCACTGCAAGCTCCGCCTCCCGAGTTCACGCCATTCTCCTGCCTCAG CCTTCCAAGTAGCTGGGACTACAGGCGCCCGCCACCACGCCCGGCTAATTTTTTGTATTT TTTAGTAGAGACGGGGTTTCACCGTGTTAGCCAGGATGGTCTCGGTTTCCTGACCTTGTG ATCCACCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCATCAGCCACCATGCCTGGC CTTTTTTTTTGTATTTTTAGTAGAGACGGGGTTTCACTATGTTGGCCAGGCTGGTCTTGA ACTCCTGACCTCGTGATCCGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTATAGCCGTGA GCCACCACGCCCGGTGGAAATCTGGTAAGCCTATCTAACCATAAACAAGTATCAAGAACA GTATCCAAGTTCTATCTCTTTTCTCCACCTCCTCCCCCTCACTTGCTTCTGTTTCTCCCT AGGGCGATCAGGAATCTCCAGATGCTTGTCTGCCTCCTACAGTACCTGAAGCCCCAGCCC CACCCCAAAAGCCCCTTAACTCTCAGAGCCAGAAACATCTTGCACCTCCGCCCCTTCTTT CTCCCCTTTTACCTTCTATCAAGCCAACCGTTCGTAAGACCAGGCAAGATGGGAGTCAGG AAGCTCCAGAGGCTCCCTTGTCCTCAGAGCTGGAGCCTTTCCACCCAAAGCCTAAAATTA GAACTCGGAAGTCCTCCAGAATGACACCCTTTCCAGCTACCTCTGCTGCCCCTGAGCCCC ACCCTTCCACCTCCACAGCCCAGCCAGTCACTCCCAAGCCCACATCTCAGGCCACTAGGA GCAGGACAAATAGGTCCTCTGTCAAGACCCCTGAACCAGTTGTCCCCACAGCCCCTGAGC TCCAGCCTTCCACCTCCACAGACCAGCCTGTCACCTCTGAGCCCACATCTCAGGTTACTA GGGGAAGAAAAAGTAGATCCTCTGTCAAGACCCCTGAAACAGTTGTGCCCACAGCCCTTG AGCTCCAGCCTTCCACCTCCACCGACCGACCTGTCACCTCTGAACCCACCTCTCAGGCTA CTAGGGGAAGAAAAAATAGATCCTCTGTCAAGACCCCTGAACCAGTTGTCCCCACAGCCC CTGAGCTCCAGCCTTCCACCTCCACAGACCAGCCTGTCACTTCTGAGCCCACATATCAGG CTACTAGGGGAAGAAAAAATAGATCCTCTGTCAAGACCCCTGAACCAGTTGTGCCCACAG CCCCTGAGCTCCGGCCTTCCACCTCCACAGACCGACCTGTCACCCCCAAGCCCACATCTC GGACCACTAGGAGCAGGACAAATATGTCCTCTGTCAAGACCCCTGAAACAGTTGTCCCCA CAGCCCCTGAGCTCCAGATTTCCACCTCCACAGACCAACCTGTCACCCCTAAGCCCACAT CTCGGACCACTAGGAGCAGGACAAATATGTCCTCTGTGAAGAACCCTGAATCAACTGTCC CTATAGCCCCTGAGCTCCCACCTTCCACCTCCACAGAGCAGCCTGTCACCCCTGAGCCCA CATCTCGGGCTACTAGGGGAAGAAAAAATAGATCCTCTGGCAAGACCCCTGAAACACTTG TCCCCACAGCCCCTAAGCTCGAGCCTTCCACTTCCACAGACCAACCTGTCACTCCTGAGC CCACATCTCAGGCCACCAGGGGCAGGACAAATAGGTCCTCTGTGAAGACCCCTGAAACAG TTGTCCCCACAGCCCCTGAGCTCCAGCCTTCCACCTCCACAGACCAGCCTGTTACCCCTG AGCCTACGTCTCAGGCTACTAGGGGAAGAACAGATAGATCCTCTGTCAAGACTCCTGAAA CAGTTGTCCCCACAGCCCCTGAGCTACAGGCTTCCGCCTCCACAGACCAGCCTGTCACCT CTGAGCCCACATCTCGGACCACTAGGGGAAGAAAAAATCGGTCCTCTGTCAAGACCCCTG AAACAGTTGTGCCCGCAGCCCCTGAGCTCCAGCCTTCCACCTCCACAGACCAACCTGTCA CCCCTGAGCCCACATCTCGGGCCACTAGGGGCAGGACAAATAGGTCCTCTGTCAAGACCC CTGAATCAATTGTCCCTATAGCCCCTGAGCTTCAGCCTTCCACCTCCAGAAACCAGCTTG TCACCCCTGAGCCCACATCTCGGGCCACTAGGTGCAGGACAAATAGGTCCTCTGTCAAGA CCCCTGAGCCAGTTGTCCCCACAGCCCCTGAGCCCCATCCTACCACCTCCACAGACCAGC CTGTCACCCCCAAGCTCACATCTAGGGCCACTAGGAGAAAGACAAATAGGTCCTCTGTCA AGACTCCCAAACCAGTTGAACCAGCAGCCTCTGATCTTGAGCCTTTTACCCCCACAGACC AGTCCGTCACCCCTGAGGCCATAGCTCAGGGTGGTCAGAGCAAAACACTGAGGTCTTCCA CAGTAAGAGCTATGCCGGTTCCTACCACCCCTGAATTCCAATCTCCTGTCACCACAGACC AGCCTATTTCCCCTGAGCCTATTACTCAACCCAGTTGCATCAAGAGGCAGAGAGCCGCTG GGAACCCTGGCTCCCTCGCAGCTCCCATTGACCATAAGCCTTGCTCTGCACCCTTGGAAC CTAAATCCCAGGCCTCAAGGAACCAAAGATGGGGAGCAGTGAGAGCAGCTGAATCCCTTA CAGCCATTCCTGAGCCTGCCTCTCCCCAGCTTCTTGAGACACCAATTCATGCCTCCCAGA TCCAAAAGGTGGAACCAGCAGGTAGATCTAGGTTCACCCCGGAGCTCCAGCCTAAGGCCT CTCAAAGCCGCAAGAGGTCTTTAGCTACCATGGATTCACCACCACATCAAAAACAGCCCC AAAGAGGGGAAGTCTCCCAGAAGACAGTGATTATCAAGGAAGAGGAAGAAGATACTGCAG AGAAGCCAGGGAAGGAAGAGGTGAGGAGAGGGTTGGGACCACAAAGCTGGGAAAAATGAC TTCAGGGCTCTGAAACTCCCACCAAGATTTTTCTCAATCTCAGGATGTCGTGACTCCAAA ACCAGGCAAGAGAAAGAGAGACCAGGCAGAGGAGGAGCCCAACAGAATACCAAGCCGCAG CCTCCGACGGACCAAACTTAACCAAGAATCAACAGCCCCCAAAGTAAGAGACAAAGGCAT GGGACTTTGTGGGAGACAGAGATGAGGGGAGGATGCAAGGAGACCTAGAGGATTGTAGAG ATGGGTGCTGATGGCATGGGTTGCCGTAACCACCTCAGGTCAACCCTTCCACAGGTGCTC TTCACAGGAGTGGTGGATGCTCGGGGAGAGCGGGCTGTGCTGGCACTGGGGGGAAGTCTG GCTGGTTCAGCGGCAGAGGCTTCCCACCTGGTCACTGATCGCATCCGCCGGACAGTCAAG TTCCTGTGTGCCCTGGGGCGGGGAATCCCCATTCTGTCCCTGGACTGGCTGCATCAGGTG AGAGGCCAAGGGATGATGACAGACCGATATAGTGGCAAGACTGCTCATATAGTGCCCTAG AAAGTGGTGGAAGGGAAGAGGCGTTACAGGAAGACAGGGGCATTGGTGAGCCAGAAGCCT GCATTGATTTAAAAGACATTTTGTGAGCTCTCTCTAAATGCTAGGCAGCAGAGCTGATTG AGGGGCTGGGCTGAGCTTTGATGCTGACTGCTGCCGTCCTTAGTCCCGCAAGGCTGGTTT CTTCTTACCCCCGGATGAATATGTGGTGACCGACCCTGAGCAAGAGAAGAACTTTGGCTT TAGCCTTCAAGACGCACTGAGCAGGGCTCGGGAGCGAAGGCTGCTAGAGGTGAGAGGCTA TCTTTTAACCTGTGCTTCAGCCCTCCCTCCAGTGCTTCCCAATCTACAATACCATCTCCA TCATTTCTTTCTCTTAGGGCTATGAGATCTATGTGACCCCTGGAGTCCAGCCACCACCAC CTCAGATGGGAGAGATTATTAGCTGCTGTGGAGGCACATACCTACCCAGCATGCCTCGGT CCTATAAGGTATGCTTAGGATGTTCTGGGTCTGGGTGAGGTGGCAGTGGCAGTTAAAGAG GTGGCTGGAATGGCAAAGATTGGAGGGAAAAAAATGGAGGTTCAGAAAGGAATATAAAGT AGTGAGAGGGTGGGGGAAAAGACCTATGGTATAGAAAGGGATAGGAATGAGGGGACAGAT CTGCTGATACCCCCATATAACAATCACCGAGATTCAGCAGCAGCTTAATTTAGATTATGC TACATTTGCTCCATCTATCCCTTTTTTCCTTTGATTTTCTCTTTTTTTTTTTTTTTTTTT TTTTGAGATGGAGTCTCACTCTCAGGCTGGAGTGCAGTGGCACAATCTCGGCTCACTACA ATCTCCGCCTCCTGGGTTCACACCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTA CAGGTGCCCGCCACCACGCCCGGCTAATTCTTTTGTATTTTTAGTAGAGATGGGGTTTCA CTGTGTTAGCCAGGATGGTCTTGATCTCCTGAGGTCATGATCTGCCCGCCTCGGCCTCTC AAAGTGCTGGGATTACAGGCGTGAGCCACCGCGCCCGGCTTTTTCCTTTGATTTTCTTTG CTGAAGTATTTCATTTCTTTTTATTTTTCTTTATTCTTTCTTTTTTTCCTTTCTCTTTCT TTGCTGAAATATTTTAAAGCAAACTGCCAATATTATATTATTTCTTCCTACATACTTAAA TATATATCTCTAAGAAATACGTACATTTTATTTCATAATCACAATGCCATTATTGATCCT AAGCAAAATTAACAGTAGTTTATTGGTCATTTGCTCACACTCCATTAATAAAATTTCTCC CATTGTCTGAAAAATGTCTCTATACAGTTGTTCAAATCAGGATTCAAATAAGGTCCACAT ACTGCCACACCTATTATCTTCTTAATTATCTTTACTCTAGAGCATCCCTTAACCCACCCA GCTTTTTTTATGCCATCTATTTCCTGCAGAAGCTGGGTCACTTGTCCTTTAGAATGTTCC TCAGTCTGGAATTTTGGGTTTGCCTCCTTGTCATATAATTTATCTTGTTCCTCTGTACTC CATATTTCCTGGAAATTGCAGATAATTGTAAAAGCTTGAATAAATTCAGGTTCATCTTTC TAGCAAAAGTATTTTTTTTTTTTGAGAGAGTCTCACTCTGTCGCCAGGCTGGAGTACAGT GGAGCAGTCTTGGCTCACTGCAACCTCCATCTCCCGGGTTCAAGCTGTTCTCCTGCCTCA ACCTCCCGAGTAGCTGGGACTACAGGCGCACACCACCACGCCCAGCTAATTTTTTTATTT TTACTAAAGACGGGGTTTCACCATGTTGGCCAGGATGGTCTCGATCTCTTGACCTCGTGA TCCACCCACCTCGGCCTCCCAAAGTGCTGGGATTATAGGCGTGAGCCACTGTGCCTGGCC TCTAGCAAGAGTATTTCTTTTTTTTTTTTCTTTTTTTTTTTCTTTTGAGATGGAGTCTTG CTCTGTAGCCCAGGCTGGAGTGCAGTGGCGCGATCTCGGCTCACTGCAAGCTCCGCCTCC TGGGTTTTCACGCCATTCTCCTGCCCCAGCCTCCCGAGTAGCTGGGACGACAGGCACCCG TCAGCGCGCCCGGCTAATTTTTTTTTTTTTTTTTTTTTTGTATTTTTAGTAGAGACAGGG TTTCACCGTGGTCTTGATCTCCTGACCTCGTGATCCACCCGCCTCAGCCTCCCAAAGTGC TGTGTAATTACAGGCATGAGCCACTGCGCCCGGCCTAGCAAGAGTATTTCATAGACAGTA TGCGGTGTGCTTCACTTGGCTTCATATTAGGAGGTATTATTTTAGTGATGGTAAGACTGG TTAGTGGGTCCTGAACCCATTTCTAGGATTCTTTTTCACCTGATTTTGCCTTTGCTCTGT CTTCCCCAGCCTCAGAGAGTTGTGATCACATGCCCTCAGGACTTCCCTCATTGCTCCATT CCACTACGGGTTGGGCTGCCCCTCCTCTCGCCTGAGTTCCTGCTGACTGGAGTGCTGAAG CAGGAAGCCAAGCCAGAGGCCTTTGTCCTCTCCCCTTTGGAGATGTCATCCACCTGAGAA CTCCACTACCCTTTTCCCTCCCAGACCACGAATTAGAAGATATGTGGAAGAAAGAACTCA GGGCGTTAGAAAGGATTGGGGTATATTGATACAACTTGTCCTGGAACATGGGTGGGACCA GAAATCTTTATGAATAAATGAAAAGATAAGGGATTTGGAAGCCACAGGTTGTTTTTTGTT TGTTTGTTTGTTTTTTTAATGGCCATTTTATTTTATTTGTATTTATAGTTTTTTATTTGT ATAGATTTAGGGGATACAAGATTTCTTACATGCATGTATTAAATGGCCATTTTAAAATTA GCTAGTTTCATGCTCAGATGTCATAAGTGGCAGCTATCTTTAGCCAGACTGTTGCAGTTA TTGCTCGATGCCACTCATGGTGTCCTACCTCCTATTTGGAAACCATCTCTATTTTTTTCT TACTGAGATTCTTACTTTGGGGTCAGGAACTTGAAGGGATGCTTGGAGTGAGTAGATTTG AGGGTCCAGTTATGGAGTGCTACTAAAACATTTTCTTCTCTCCTGGCCTCTGGAAGCATC TTTAGCTTTGACTTTGGGCAAGTCTCTGTACTTTTCTGGCCAGCTTTTCCAGGATTTATA AAATTAGAGCTTCGGCTTGACCTCTGTGATAAATAAATATTCACTCTGTGCCTTA OMIM ID 607593