| Entrez gene ID | | 9516 |
| Official gene symbol | | LITAF |
| Full name | | lipopolysaccharide-induced TNF factor |
| Aliases | | ,FLJ38636,MGC116698,MGC116700,MGC116701,MGC125274,MGC125275,MGC125276,PIG7,SIMPLE,TP53I7, |
| Gene summary | | Lipopolysaccharide is a potent stimulator of monocytes and macrophages, causing secretion of tumor necrosis factor-alpha (TNF-alpha) and other inflammatory mediators. This gene encodes lipopolysaccharide-induced TNF-alpha factor, which is a DNA-binding protein and can mediate the TNF-alpha expression by direct binding to the promoter region of the TNF-alpha gene. The transcription of this gene is induced by tumor suppresor p53 and has been implicated in the p53-induced apoptotic pathway. Mutations in this gene cause Charcot-Marie-Tooth disease type 1C (CMT1C) and may be involved in the carcinogenesis of extramammary Paget's disease (EMPD). Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq] |
| Location | | Chromosome: 16 Locus: 16p13.13 |
| Gene position | | 11681322 - 11641578 Map Viewer |
| Gene orientation | | minus |
| Gene size | | 39745 bp |
| Gene sequence |
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| OMIM ID | | 603795 |
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