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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for SLC25A27 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID9481
Official gene symbolSLC25A27
Full namesolute carrier family 25, member 27
Aliases,FLJ33552,UCP4,
Gene summaryMitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. Transcripts of this gene are only detected in brain tissue and are specifically modulated by various environmental conditions. [provided by RefSeq]
LocationChromosome: 6   Locus: 6p11.2-q12
Gene position46620679 - 46645927  Map Viewer
Gene orientationplus
Gene size25249 bp
Gene sequence