| Entrez gene ID | | 942 |
|
| Official gene symbol | | CD86 |
|
| Full name | | CD86 molecule |
|
| Aliases | | ,B7-2,B70,CD28LG2,LAB72,MGC34413, |
|
| Gene summary | | This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in two transcript variants encoding different isoforms. Additional transcript variants have been described, but their full-length sequences have not been determined. [provided by RefSeq] |
|
| Location | | Chromosome: 3 Locus: 3q21 |
|
| Gene position | | 121774221 - 121839983 Map Viewer |
|
| Gene orientation | | plus |
|
| Gene size | | 65763 bp |
|
| Gene sequence |
| |
|
| OMIM ID | | 601020 |
|
|
|
