| Entrez gene ID | | 93 |
| Official gene symbol | | ACVR2B |
| Full name | | activin A receptor, type IIB |
| Aliases | | ,ACTRIIB,ActR-IIB,MGC116908, |
| Gene summary | | Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor. [provided by RefSeq] |
| Location | | Chromosome: 3 Locus: 3p22 |
| Gene position | | 38495790 - 38534633 Map Viewer |
| Gene orientation | | plus |
| Gene size | | 38844 bp |
| Gene sequence |
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| OMIM ID | | 602730 |
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