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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for CD8A (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID925
Official gene symbolCD8A
Full nameCD8a molecule
Aliases,CD8,Leu2,MAL,p32,
Gene summaryThe CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen acts as a corepressor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The coreceptor functions as either a homodimer composed of two alpha chains, or as a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha chain isoforms. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
LocationChromosome: 2   Locus: 2p12
Gene position87035519 - 87011728  Map Viewer
Gene orientationminus
Gene size23792 bp
Gene sequence
OMIM ID186910