Database of mammalian genes
Home

Home Search Browse Statistics User guide FAQs Links Questions Contribute Download


Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for LATS1 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID9113
Official gene symbolLATS1
Full nameLATS, large tumor suppressor, homolog 1 (Drosophila)
Aliases,WARTS,wts,
Gene summaryThe protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments. [provided by RefSeq]
LocationChromosome: 6   Locus: 6q24-q25.1
Gene position150039392 - 149982051  Map Viewer
Gene orientationminus
Gene size57342 bp
Gene sequence
OMIM ID603473