| Entrez gene ID | | 9113 |
| Official gene symbol | | LATS1 |
| Full name | | LATS, large tumor suppressor, homolog 1 (Drosophila) |
| Aliases | | ,WARTS,wts, |
| Gene summary | | The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments. [provided by RefSeq] |
| Location | | Chromosome: 6 Locus: 6q24-q25.1 |
| Gene position | | 150039392 - 149982051 Map Viewer |
| Gene orientation | | minus |
| Gene size | | 57342 bp |
| Gene sequence |
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| OMIM ID | | 603473 |
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