| Entrez gene ID | | 9097 |
| Official gene symbol | | USP14 |
| Full name | | ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) |
| Aliases | | ,TGT, |
| Gene summary | | This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. Mice with a mutation that results in reduced expression of the ortholog of this protein are retarded for growth, develop severe tremors by 2 to 3 weeks of age followed by hindlimb paralysis and death by 6 to 10 weeks of age. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq] |
| Location | | Chromosome: 18 Locus: 18p11.32 |
| Gene position | | 158483 - 213739 Map Viewer |
| Gene orientation | | plus |
| Gene size | | 55257 bp |
| Gene sequence |
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| OMIM ID | | 607274 |