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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for USP14 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID9097
Official gene symbolUSP14
Full nameubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)
Aliases,TGT,
Gene summaryThis gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. Mice with a mutation that results in reduced expression of the ortholog of this protein are retarded for growth, develop severe tremors by 2 to 3 weeks of age followed by hindlimb paralysis and death by 6 to 10 weeks of age. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq]
LocationChromosome: 18   Locus: 18p11.32
Gene position158483 - 213739  Map Viewer
Gene orientationplus
Gene size55257 bp
Gene sequence
OMIM ID607274