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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for SART1 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID9092
Official gene symbolSART1
Full namesquamous cell carcinoma antigen recognized by T cells
Aliases,Ara1,HOMS1,MGC2038,SART1259,SNRNP110,Snu66,
Gene summaryThis gene encodes two proteins, the SART1(800) protein expressed in the nucleus of the majority of proliferating cells, and the SART1(259) protein expressed in the cytosol of epithelial cancers. The SART1(259) protein is translated by the mechanism of -1 frameshifting during posttranscriptional regulation; its full-length sequence is not published yet. The two encoded proteins are thought to be involved in the regulation of proliferation. Both proteins have tumor-rejection antigens. The SART1(259) protein possesses tumor epitopes capable of inducing HLA-A2402-restricted cytotoxic T lymphocytes in cancer patients. This SART1(259) antigen may be useful in specific immunotherapy for cancer patients and may serve as a paradigmatic tool for the diagnosis and treatment of patients with atopy. The SART1(259) protein is found to be essential for the recruitment of the tri-snRNP to the pre-spliceosome in the spliceosome assembly pathway. [provided by RefSeq]
LocationChromosome: 11   Locus: 11q13.1
Gene position65729160 - 65747607  Map Viewer
Gene orientationplus
Gene size18448 bp
Gene sequence
OMIM ID605941