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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for CCND3 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID896
Official gene symbolCCND3
Full namecyclin D3
Aliases,-,
Gene summaryThe protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activtiy is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. The CDK4 activity associated with this cyclin was reported to be necessary for cell cycle progression through G2 phase into mitosis after UV radiation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
LocationChromosome: 6   Locus: 6p21
Gene position42016610 - 41902671  Map Viewer
Gene orientationminus
Gene size113940 bp
Gene sequence