| Entrez gene ID | | 8878 |
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| Official gene symbol | | SQSTM1 |
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| Full name | | sequestosome 1 |
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| Aliases | | ,A170,OSIL,PDB3,ZIP3,p60,p62,p62B, |
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| Gene summary | | This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. Mutations in this gene result in sporadic and familial Paget disease of bone. [provided by RefSeq] |
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| Location | | Chromosome: 5 Locus: 5q35 |
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| Gene position | | 179233388 - 179265078 Map Viewer |
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| Gene orientation | | plus |
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| Gene size | | 31691 bp |
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| Gene sequence |
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| OMIM ID | | 601530 |
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