| Entrez gene ID | | 8856 |
| Official gene symbol | | NR1I2 |
| Full name | | nuclear receptor subfamily 1, group I, member 2 |
| Aliases | | ,BXR,ONR1,PAR,PAR1,PAR2,PARq,PRR,PXR,SAR,SXR, |
| Gene summary | | This gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG (CUG) translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized. [provided by RefSeq] |
| Location | | Chromosome: 3 Locus: 3q12-q13.3 |
| Gene position | | 119499331 - 119537332 Map Viewer |
| Gene orientation | | plus |
| Gene size | | 38002 bp |
| Gene sequence |
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| OMIM ID | | 603065 |
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