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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for TNFRSF18 (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 8784 Official gene symbol TNFRSF18 Full name tumor necrosis factor receptor superfamily, member 18 Aliases ,AITR,GITR,GITR-D, Gene summary The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq] Location Chromosome: 1   Locus: 1p36.3 Gene position 1142089 - 1138888  Map Viewer Gene orientation minus Gene size 3202 bp Gene sequence >TNFRSF18:complement(617520..620721):Length=3202 GTCTACACCCCCTCCTCACACGCACTTCACCTGGGTCGGGATTCTCAGGTCATGAACGGT CCCAGCCACCTCCGGGCAGGGCGGGTGAGGACGGGGACGGGGCGTGTCCAACTGGCTGTG GGCTCTTGAAACCCGAGCATGGCACAGCACGGGGCGATGGGCGCGTTTCGGGCCCTGTGC GGCCTGGCGCTGCTGTGCGCGCTCAGCCTGGGTCAGCGCCCCACCGGGGGTCCCGGGTGC GGCCCTGGGCGCCTCCTGCTTGGGACGGGAACGGACGCGCGCTGCTGCCGGGTTCACACG ACGCGCTGCTGCCGCGATTACCCGGGTAAGTAAACCGCGTTTACTTAACGCGGACCGGCC AAGGCGTCCCGCGGAAGCCGGGATGGGTGGGCGCCCCCCTTCCCGTGCTCAGACCGGCGT TGCTGAGGTCTAAGGAGGGTGGGCACAGAGCCGCCAGCAGCGGGAGCCTTCCGGAGGGAG GCAGGATCCCAGAGGGAGGCGGAGGTGTGCCAGCTCCAGCCAGTGGCCCCGGCCGGGAGC AGGGGTGAGCCAGGTGGGAGCGCCCTCAAGAGGGGTCTGGGGTCTGGAGGTGGAGGACGG CTGTTCCAGGTCCTGCTGGGCGGGTCGTGAGCCCTTGGCCATCGCCCAGCCCCCTCCTGC CCAGTTGAGGGCCCCCCTGCACCACCGTCTGGCCTGCTGCCTGCCTCTGACCTGCACCTG GGGATGAGGGTTCAGCTGACACGGCTGGTCTGGAGAGGAAGCTGGCAGGGAAGTCACCCC AGAGCTTCTTCCTCCAGGGCCTGTGGGTTGGGAAGGGAGGCTCTGTCCGGAGGCCCAGTG TGGCTGGTGGTGGGGACAGCAGCGCCCAGACACCAGGCAGGCGGCCTCTGAGGTGTCGAC GGGCCTCCAGGGGACTGTGCACTGTTGGGGGCCACCCCTGGGTCCTGCAGGGGCAGCTCC TGGTTGCATATGGAGTTAGCACCTGGGCAGGGGCAGCTGTGGGGCGCAAAGGGGGAGTAG CCAGGCCACATGGCCCCAGGAGAAAGAGACAGCTGGATAAACCCAGGGTCCAGACTCCCA GCCAGGAGCCCTCTGCTCCCTGGAGCCAACTGTGGGTGGAGAACGGACAACCTCACTCCC CTGGAGGGCCGAGGGGAGGCCTGGGGAGGAGGGGGCCTCAGCCCAGCTGCTGGGGGGCTG GCCTGTCTCCTGCCCAGGCGAGGAGTGCTGTTCCGAGTGGGACTGCATGTGTGTCCAGCC TGAATTCCACTGCGGAGACCCTTGCTGCACGACCTGCCGGCACCACCCTTGTCCCCCAGG CCAGGGGGTACAGTCCCAGGGTAAGTCCTGGAGGTGCCTCTGGGAGTCCACACAGGCCAG GGGTTCCACTAGGGCCCGAGGCAGAGCTCGTGGGCACAGGTGTCCGGCGAGGACATGTGG TGTGTGGGGTCCGGAGTCCTGTGAGGCCGGGCAGGCCAGGCCATGCTCAGGCACCACAGG CCATGAAGCTCTGGGGGTGTCCTGTCCCTGCTTTCTCAGCCTGGGCTTCTCCATCCAGCA CGAGGGCTGTGAGAACCCTGCGGGGAGGTGGGGGCGGGTTCCAGGAGCTGTCTGGCTCTC AGGCCCGGGACACCCATCCTGTCTGTCCTCACCACATACTGAAAGAGCCTGCCCTGTGCC CCCCGGAGTCCTGTCTGGGGCCTGGGGCTGCACCCTGTTCTGGAAGGAGCAGCTCAAGTC CTCTTAGCGGCTTGTTTACCTGACAGGAGAGGTCAGGCTGGGCACATGAGAGCTGGGAGA AGGTACAACTGGGGAGGTTGTGTCAGGTTGGACGGGGCAGGGTCTGGGGTCAACTGGGAC CCAGCCTCACTCTCTCTGGGACCCTCACTGTTCTCCACCCTCTGTTCTACTGGGTCCTGC CTGGCTTCTGCCCACCCTCAGCCCCCAATGGGCAGGCCTTTCCCCTCCCTGGCAGGCCCA CTGCACTCTGCGCACCTCCCCCAGGTGCCCTCACTGGGCCCCACCCCAGACGCCCCACCT GGGACGGGCAGACATGGGCCCCAGTCCTGGGCCATGAAGAACTCTGTTGAATGGATGATG GGGGGGGCATTCTACTCAGCACCCAGACCCCAGATGGACCCCTGCACTGGCCTGACGCCC TCCTCATCCATCCCAGCAACTCCACCAGCCTCCCTCCCTCCCTCCCCCCACACCCCACAC CAGGGAAATTCAGTTTTGGCTTCCAGTGTATCGACTGTGCCTCGGGGACCTTCTCCGGGG GCCACGAAGGCCACTGCAAACCTTGGACAGAGTGAGTCCTGGGTGGGCCCTGCCGGTGGC CGGGTGGTCCAGGCCCACTCTGAGGAAGGGTCCTCTCCTGTCCCTTGCCCCAGACAGCAC GGAGGGCAGCAGCCGGGGGCTGATCGGAGGCCGTGTCCGGGGGCTGATAGGAGGCCGCGT CCATGTATTCCAGCTGCACCCAGTTCGGGTTTCTCACTGTGTTCCCTGGGAACAAGACCC ACAACGCTGTGTGCGTCCCAGGGTCCCCGCCGGCAGAGCCGCTTGGGTGGCTGACCGTCG TCCTCCTGGCCGTGGCCGCCTGCGTCCTCCTCCTGACCTCGGCCCAGCTTGGACTGCACA TCTGGCAGCTGAGGAGTCAGTGCATGTGGCCCCGAGGTCTGTCACAGCCTGGTGCGGGGA GGTGGGAGCATGGCTGCCTGCTGACCGTGGCCCCCCTGCAGAGACCCAGCTGCTGCTGGA GGTGCCGCCGTCGACCGAAGACGCCAGAAGCTGCCAGTTCCCCGAGGAAGAGCGGGGCGA GCGATCGGCAGAGGAGAAGGGGCGGCTGGGAGACCTGTGGGTGTGAGCCTGGCCGTCCTC CGGGGCCACCGACCGCAGCCAGCCCCTCCCCAGGAGCTCCCCAGGCCGCAGGGGCTCTGC GTTCTGCTCTGGGCCGGGCCCTGCTCCCCTGGCAGCAGAAGTGGGTGCAGGAAGGTGGCA GTGACCAGCGCCCTGGACCATGCAGTTCGGCGGCCGCGGCTGGGCCCTGCAGGAGGGAGA GAGAGACACAGTCATGGCCCCCTTCCTCCCTTGCTGGCCCTGATGGGGTGGGGTCTTAGG ACGGGAGGCTGTGTCCGTGGGTGTGCAGTGCCCAGCACGGGACCCGGCTGCAGGGGACCT TCAATAAACACTTGTCCAGTGA OMIM ID 603905