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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for TNFSF12 (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 8742 Official gene symbol TNFSF12 Full name tumor necrosis factor (ligand) superfamily, member 12 Aliases ,APO3L,DR3LG,MGC129581,MGC20669,TWEAK, Gene summary The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is a ligand for the FN14/TWEAKR receptor. This cytokine has overlapping signaling functions with TNF, but displays a much wider tissue distribution. This cytokine, which exists in both membrane-bound and secreted forms, can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. This cytokine is also found to promote proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis. Alternative splicing results in multiple transcript variants. Some transcripts skip the last exon of this gene and continue into the second exon of the neighboring TNFSF13 gene; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13. [provided by RefSeq] Location Chromosome: 17   Locus: 17p13 Gene position 7452375 - 7461207  Map Viewer Gene orientation plus Gene size 8833 bp Gene sequence >TNFSF12:7055749..7064581:Length=8833 CTCTCCCCGGCCCGATCCGCCCGCCGGCTCCCCCTCCCCCGATCCCTCGGGTCCCGGGAT GGGGGGGCGGTGAGGCAGGCACAGCCCCCCGCCCCCATGGCCGCCCGTCGGAGCCAGAGG CGGAGGGGGCGCCGGGGGGAGCCGGGCACCGCCCTGCTGGTCCCGCTCGCGCTGGGCCTG GGCCTGGCGCTGGCCTGCCTCGGCCTCCTGCTGGCCGTGGTCAGTTTGGGGAGCCGGGCA TCGCTGTCCGCCCAGGTGAGGCCCCGCTGCGCACCCCTTCTTGGGCACATCAGGAGCTGA GACTGCAGAGGGGCCGCTGGGGGCCGCGTGGGCTGAAGGCAAGGGGAAGGGAGGATGGGT GGAGGGTGAGATGTCAGGTGGAGCGGCACAGGGTGACGCTCCCTCCTTCCCAGCAGGAGC CTGCCCAGGAGGAGCTGGTGGCAGAGGAGGACCAGGACCCGTCGGTGAGTGGGCGTGGGC GCGGTCTGCAGGCTGCTGGGGCATGGGAAGTGTGCACAGCCGAGGCTGCAGGTGTGTGCA GCTGTGCCAGCCGTACTCGAGGTGTGTGCAGGGTGTGTGTGAACACAGTGCGTGCATGGG TGCGTGTCTGCAGGGGTGTGTGTGCGTGGTGACAACTCTGTGTGAGGGGTTTGTGCTGGG GTTGTGCCACCTGAGTCTGAGGTGTTTATTGGCTGGGGGTGACGTGGTTGTATAAGATAT GTGAGTCTGCGTGGAAGAGGGGTGCGGTTGTGTACAGGGTGTGTATCCTCTGTGCGTGGT GACTGGGTGCGGGCATGTGTGCAATGTGCCAATTGAATGCAGGGTCTGCGTTGGTTGTGT GTGTGGGTGGGAAAGTGTAGCTGGTCTAGAGGAAAGGGTGAGGACTGGGGCCTGACTCCC AGCTTCACCTTTGCCCGGGGCCCCAGCTGTAGTTGGCTGAGGGGCTTAATCTGTCCCTGA CTTCTGTGTCTATTGCTGGCTGGTGGCTCTCCTGACAGGCCCCGTATGTCTCACTTTATA TCTCTGGGAGTCTGTGGTTGAACCCTGCCCTAATTCCCCTAGGAACTGAATCCCCAGACA GAAGAAAGCCAGGATCCTGCGCCTTTCCTGAACCGACTAGTTCGGCCTCGCAGAAGTGGT GAGCATCCCTCTATCCCAACCTCAGGAAGCGGGCAGAGCAAAAACCATTATCCACAGGGA GAAACTGAGGCACGGAGGGTGAAAGGAGTTCAGAGTCATGCAGCTAACCAGCCAAGACTC AAACCTAGGGATTCTCGCCCTCCTCTGAAGCTCCTTCTGTCATATGGATGTGCTCCTTCA GACCCTACCCCAAACAGGAAGGCAGGGTGGCCATGAGTTAGAAGAACTACTGGGATCCTG ATGGAGACTAGGCCTGGCAGTCAGAGGCCTGGGCCCCGGTAGGCAAAGAGACTTAGGAAT GGGATGATGGGGTGGCCGGATGACCACGTGTCCAAGTCGGCATGCAGTTGTCCTGGCCCC CACCTGTTATCTCGGTGTGATTAATAGCAGCTTCCCGTTTTGCTCTCAGCAGTATCCCAG TGTGGATGACAAATTATAGTCACTCTACTTACTGAGGAAGATGAGGCCTGAGATTCTAAG GCCAGGAGTCTGGACAAGAATAAGGATGCCAGGGTTCCTGAGAGGGGAATGGGGCTGGGA GAGTTGCTCTGGGACCCCCACTAGGGCCCGCTTTGCTCATCTGTCTTTCCTTGATCCTCA GCACCTAAAGGCCGGAAAACACGGGCTCGAAGAGCGATCGCAGCCCATTATGAAGGTGGG TGATGGGTGAGCCATACCCAGGAGGAGAGGGGCAGGTGGCAGAGGGTCAGGGCAGGTCTC ACCAGCCTTTTCCTGTACTTTACAGTTCATCCACGACCTGGACAGGACGGAGCGCAGGCA GGTGAGACCCCATCCCCCGACACAGCACTGGCCTCCTGGGAAAAGGGCCCTTGAAAACCT TTGACCTCCCACTCCCTTCCCGGCCATCAGTCTCAGAACCACAGAAGCCAGTTCATGAAG GTCTTGGTTCTCTCTGTGACCCAGGCGTGGGACCCCATGAAAGACCCCTACTCTTCCCCA GAACTCTGCCCAGTTCCCCCAGCAAATCACTGTCCCAGCTCTCTCCTTCAGCCCTCATTC TTCTCCAAGAAGCACTTTTCATTCTTTTTTCTTCTGTCTCCTCCATATTCCACGTTCTGA TGATCTTTTTCTCTAAATGCTGCTAGTGTCTGCTCATCTTTTCCATTTCTACCCCACCCT CTACCTCAGCACCGTGACCTCAGAACCTCAAATCCAGCCTCTTGCTGCTTCCCCACTCCA CACCCTCCCTACCCCTCCACTCCATCTGACCTGTGCTGCCATGCTGAGCCCCTAAACTTC ACTTTTCTTGTGGTATTGGCTCTCTACATGGCTTCCAGTCTCTTCGTGGTCTGGTCTCAA CCTAATTTCCCTGCACTCTTATGCTGTCTTCATGTTTGCTGCGCTGACACCCCTGCTCCC GGTGTGCCTCTTCTGGACTTTGCACATACCATCCCCCTCACCAGAATGTCTTTCCACTGT GAGAGGCAGGGAGGCATGAGGAGTGCTCAGCCGAGGGGTTCACAGCAGAGATGGTGAGAA GTGGATGGGTTCAGCCTGTGTCCTGAAGATATTACTGACTTATGGGTTGGAGGTGAAGAA TAAAAGAAAGGGAGGAATCACAGATGACTTCTAGATTTTTTATTTTTTTTAAGACAGTCT CGCTCTGTCACCCAGGCTGGAGTGCAGTGGTGCAATCTCGGCTTACTGCAACCTCTGCCT CCCAGGTTCAAGAGATTCCCGTCTCAGCCTTCCAAGTAGCTGGGATTACAGGCGTGTGCC ACCACGCCTGGCTAATTTTTGTATTTTTAGTAGAGATGGGGTTTTGCCATGTTTTCCAGG CTGGTCTCAAACTCTTGACCTCCAGTGATCTGCCCGCCTCGGCCTACCAAAGTGCTGGGA TTACAGGCATGAGCCACTGCACCCAGCCAGCTTCTAGATTTTTAACTTGGGTATCTCTGG GAAGAATGATGCCATTTCCTAAGAAGGGATTGACCAAGGAATAAATAGGTTGGGAAGTAT GTAAGATAATTATTAACGTTGAGAAGTCTAAAATAAACAAGCGGATAAATGACAATAAAG TAAATTCCAGAAATGGATGGCTGGACATTGTCGACTAGCTTAGGCTAGGTCAGGACGGAT AAAGCCAGGAGTCATGGCCATATGGATGGCTTTTTTTTTTTTTTTTTTGAGACAGAGTCT CGCTCTGTCACCCAGGCTGGAGTGCAGTGGTTCGATCTTGGCTCACTGCAACATCTGCCT CCTGGGTCCAAGCGATTCTCCTGTCTCAGCCTCCCAAGTAGCTGAGATTATAGGCGGGTG CCACCACACCCAGCTCATTTTTGTATTTTTTAGTAGAGACAGGGTTTCACCGTGTTGGCC AGGCTGGTCTTGAACTCCTGATCTCAGGTGATCCGCCAGCCTCAGCCTCCCAAAGTGCTG GGATTACAGGTGTGAGCCCTTGTGCCCGGCCTATCGATGGCATTTAAAGCCACAGGATTG GGTGAGACGCCAGGAGAAAGAAGGGCCCCACGAATGAAGCCCTGAGACTCTTGGGCATCT TGAAGTGGAGCTGAGGGGAAAACCAGCAGAGACTGAAAAGAAGCTGGAGAGAGAGGAAGA AACCCAGGGAGGGTGGCATCCTGGATTCGGAGAAACCACTGTTTCAAGGAGGATGTGGCT GTCTGTGTTGAATGCAGCTGAGAGATCACATGAAATGAGAACAGAGAAATGATGGCTGGG TTTGGTAACGTGAAAGTCCTGCTGACCTTAAAGAGGGTGGTTTCAGTGGCATAGTTAGAA CAGGAAGGCAGTGTGCATTGGGTTGAGAAGAAAATGAGAAATAAGGAACTGGAGGCAGGG ACAACCTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTGTGACAGAGTTTCAC TCTTGTCACCCAGGCTGGATCCAGTGCAATGGCACGATCTCGGCTGACCGTAACCTCCAC CTCCCGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCCCAGTAGCTGAGATTACAGGCATG CGCCACCACGCCTGGCTAATTTTGTATTTTTAGTAGAGACAGGGTTTCTCCATGTTGGTC AGGCTGGTCTCAAACTCCCGACCTCAGGTGTTCCACCCGCTTCGGCCTCCCAAAGTGCTG GGATTACAAGCATGAGCCACTGCACCCGGCCTAGGACAACCCTTTTTAGAAGTTTCTCTG TAACAAGGAGCAGAGAAATAGGCCAGTAGGTGGAGGGGTGTGTGGACCAAGGAAAAGTTT AGTTCTGTGAACAATACTATTTTCATCTGATCTAACATGTACTGAGGGCTTTCTTGAGAT AGGCACTGTGTCTGGCACTTGTGTTTGGTCTTATCTAATCCTCACAACAGCCCTAAAAGG AAGATACTCTAATTACCTCCATTTTACAGATGGAGGTTACACAACTTGTCTGAGGCCATG AGATACTAAGTGGTGGAGCCAAGATTTGAACCCAGCTAGAATGTGCCTGTGTACTGGACA TGGTCTGCATGAAAGGCGAGGTGGCTGGTGCAGGGGTGAGGGGTCCATGCAGGGGCCACA TCCAAAAAGGGGAGAGGGAAGTTTCCAGAAAGAAGAGAGGACACATCTCCCACCATTACC AGAGGGTCAAAGGAGAACAAGAGACCAGGTGGGTTTGTAGATTTGCTGGGGGGAGATGAG GGAACCTTTGCTCGATGACTTCTAGGTCCTCTGGACAACTAGGGAGATGGAGACAGGAGA TTTGAGGAGAAATGGTACAAAATCTCAACTTGCTGATTATGAAAGCAAGCTTCGTGGGGG AATGTAAGATTGCCAGGCAGGACGGAATGTCCAGGTGAGGTTTGTGGCTGGAGACAAGTG ATATACCAGGCAAGCCCTCCGTGCTCCTGGGCACACCATGCCCTTAGGCTACAAGCAGCC TTTGCTTAGGCTGGCTTCGTAGCTAGGAATGCCCTCTCTTCTCTGCCCTCCCTACTCTTC ATGCCCAGATCAGCCTTCCTCCCCTCTGTATAGACCACTTATTTTGGCAATTATCCAGAC ATTCATTCATTCATTGACTCAACAGGCATTGAAGACCTACTGTTTGCTAGGGGCCAGGCT AGGTGCCCACAGCAACTAATATCCAGACTCTTTTTTTTTTTTTTTTTTTTTTTTGAGATG GAGTCTCACTCTGTCGCCCAGGCTGGAGTGTAGTGGCGCGATCTCGGCTTACTGCAAGCT CCGCCTCCTGGGTTCATGCCATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGACTACAGG CGCCCGCCACCACGCCTGGCTAATTTTTTTTTATTTTTTAGTAGAGACGGGGTTTCACCG TGTTAGCCAGGATGGTCTCGATCTCCTGACCTCGTGATCCACCCAACTCGGCCTCCCAAA GTGCTGGGATTACAGGCGTGAGCCACCGCGCCCAGCCGGTCAGACCCATTTTTTTTTTTG AGATGGAGTTTTGCTCTTGTTGCCCCAGCTGGAGTGCAGTGGCGCCATCTCGGCTCACTG CAGCCTTCTCGGGTTCAAGTGATTCTCCTGCCTCAGTCTCCCGAGTAGCTGGGACTACAG GCGCCTGCCACCACGCCTGGCTAATTTTTTTTTTATGTTTTAGTAGAGACGGGGTTTCAC CGTGTTAGCCAGGAGCGTCTCGATCTCCTGACCTCGTGATCCACCCACCTTGGCCTCCCA AGGTGCTGGGATTACAGGCGTGAGCCACTGTGCCCAGCCTCAGACCAACTCTTAAGGAGT CACTGTCTAGGAGAGGAAACAAGCATATAAATTTGTAATTACAGGAACATACAAAAAAAA TTAGCCAGGTTTGGTGGCACATGCCTGTAATCCCAGCTACTCAGGAGGCTGAAGCATGAG AATCACTTGAACCCGGGAGGCGGAGGCTGCAGTGAGCCGAGATTGTGCCACTGCACTCCA GCCTGGGTGACAAGAGTGAGACTCCATCTCAAAAAAAAATTTGTAATTACAGTGGAATAT GACAAGAACAATAATAAAAGTGGCCAAGATACCTGGCAACACAGGGGAAGACAGACATGG CTGTGGAGTCAGGGATTCTCTCCCTGCATCGCAAGGTGCCGCTGGGCCTTGAAGCAGGAG CGTAAGACAAGACAGGCAAGGGGTCAAGAATGGTGGGTGCAAGCAGAAGCAGCCCCTGGG GCAAAAGCCCCGGGTTTGCCCAGAGCATGATGAGGCTGGGGGACTCTAAGTTCAGCGTGG CAGAAGCAGAAAGTGCTAGAGGAGCGAGATGGGGATGAGGCTGGAGACAGAAGCCAGGCC ACACGGTGGCATGTGGGAACTATTCTGAGGTGAGCCATCGGAAGGAGGAAGGCGAGGCGA GGCGGGCTTACGTCTGCATCTTAGAGACTCATTCTGTGGCTTTGTGTAGGGAATAAACTG GAGGAAGCCAGAATGGAAACAGGGAATGCTGTGAAAACCAGACAGAGGCACCAGATGGGG GAGAGAGGGGAGAGAGCTATTTAGGAGGCAGGATAGATAGGAACTGGTGATCGATTAATG ATGTAGGTAAAGGAGAGGGAGGCTTGAATATCCCCCTGGTGGCAAAACCAGAAGCCAAAT GTGGAAAACAGACAGTAAAGCAAGAGTGGGATGAGGGGGGTCAGCTCAGTGTTGGTTGAG ATGAGTTTGAGGGGCTATTGCTGTTCAGATGGTGCAGTTGGCAGGGTAAGGAAGGGAAGG AAACTTCAGGGCTGGAGACTCTGCAGAGCACAGGTTGTGGGAACCCATTGGTGGAAATAA AAATGCCCAGTGAGCGTTTTTTTTGTTTTTTTTTTTTTTTGGAGACAGAGTCTAGCTCTG TTGCCCAGGCTGGAGTGCAGTGGCATGATCTTGGTTCACTGCAACCTCCCCATCCCAGGT TCAAGTAATTCTCCTGCCTCAGCCTCCCATGTAGCTAGGATTACAGGTGCCTGCCACCAT GCCCTGCTAGTTTTTGTATTTTTAGTAGAGACGGGGTTTCACCTTGTTGGCCAGGCTGGT CTCGAACTCCCGACCTCAGGTGATCCGCCCACCTTGGCCTCTCAAAATGCCGGGATGACA GGCGTGAGCCACTGCACCTGGCTGAGCATGATGTTTTCAAGGCACATCTGTGCCATAGTG TGTATCAGTACTTCACTCTTTTTATGGCCAAATAATATTCCATTATATGGATAGACATTT TGTTGATGGACAATTGGGTTTCATTTTATTATTTTTAGTTGTACTAATTCAGATAATGTA TGTTTACATCCTCCATATAAAAGAAGCAAATAATATAGATATCCATGAAGTAAAACATTA AATCCCCTCACGCTTCTCCTTCAGTTCTACTCTTCTCCCCAGAAGTGACTGCAGGTGACA ATCTGCCCTGAATGTCTCTGGCCATATACATTAGATTTTTTCACATAACTTCCTAGTCAA CTATGGGCATCATAGGGGATGGGTCCTCCCTTGCCCGGGGTGATCTATGTGTCTTCTGGG TAAAGTGGGCGCCGAATGTTCATATGCTCAATGGATCCCTGGGGAGTGTGGGGGAGTCCT GTAGAGAGACGTTTCCTTATCTCTGAGCATCCGTGTTCAGGTGTGGACGGGACAGTGAGT GGCTGGGAGGAAGCCAGAATCAACAGCTCCAGCCCTCTGCGCTACAACCGCCAGATCGGG GAGTTTATAGTCACCCGGGCTGGGCTCTACTACCTGTACTGTCAGGTAAGCCCCATCTGG CTGCATGGGTAACGCAGTAAGAGAGTGGCGAAGGGTTTGCCAGGAGAGTGGGGGACAAGC TACAGGGCTGGGAGGGTGAGTTGGGGTTTGGGTGGGATGGGATGCCTGCGTCGCTGAGGA AATTGGAAATTGAGGCGAGGGCAGGCAGAGGCCTGGACTCGGCCTGTTGTCCCCACCCCA GGTGCACTTTGATGAGGGGAAGGCTGTCTACCTGAAGCTGGACTTGCTGGTGGATGGTGT GCTGGCCCTGCGCTGCCTGGAGGAATTCTCAGCCACTGCGGCGAGTTCCCTCGGGCCCCA GCTCCGCCTCTGCCAGGTGTCTGGTCTGTTGGCCCTGCGGCCAGGGTCCTCCCTGCGGAT CCGCACCCTCCCCTGGGCCCATCTCAAGGCTGCCCCCTTCCTCACCTACTTCGGACTCTT CCAGGTTCACTGAGGGGCCCTGGTCTCCCCGCAGTCGTCCCAGGCTGCCGGCTCCCCTCG ACAGCTCTCTGGGCACCCGGTCCCCTCTGCCCCACCCTCAGCCGCTCTTTGCTCCAGACC TGCCCCTCCCTCTAGAGGCTGCCTGGGCCTGTTCACGTGTTTTCCATCCCACATAAATAC AGTATTCCCACTCTTATCTTACAACTCCCCCACCGCCCACTCTCCACCTCACTAGCTCCC CAATCCCTGACCCTTTGAGGCCCCCAGTGATCTCGACTCCCCCCTGGCCACAGACCCCCA GGGCATTGTGTTCACTGTACTCTGTGGGCAAGGATGGGTCCAGAAGACCCCACTTCAGGC ACTAAGAGGGGCTGGACCTGGCGGCAGGAAGCCAAAGAGACTGGGCCTAGGCCAGGAGTT CCCAAATGTGAGGGGCGAGAAACAAGACAAGCTCCTCCCTTGAGAATTCCCTGTGGATTT TTAAAACAGATATTATTTTTATTATTATTGTGACAAAATGTTGATAAATGGATATTAAAT AGAATAAGTCATA OMIM ID 602695