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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for PPFIBP1 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID8496
Official gene symbolPPFIBP1
Full namePTPRF interacting protein, binding protein 1 (liprin beta 1)
Aliases,L2,SGT2,hSGT2,hSgt2p,
Gene summaryThe protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. It has been proposed that liprins are multivalent proteins that form complex structures and act as scaffolds for the recruitment and anchoring of LAR family of tyrosine phosphatases. This protein was found to interact with S100A4, a calcium-binding protein related to tumor invasiveness and metastasis. In vitro experiment demonstrated that the interaction inhibited the phosphorylation of this protein by protein kinase C and protein kinase CK2. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq]
LocationChromosome: 12   Locus: 12p11.23-p11.22
Gene position27677045 - 27848496  Map Viewer
Gene orientationplus
Gene size171452 bp
Gene sequence
OMIM ID603141