| Entrez gene ID | | 8493 |
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| Official gene symbol | | PPM1D |
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| Full name | | protein phosphatase, Mg2+/Mn2+ dependent, 1D |
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| Aliases | | ,PP2C-DELTA,WIP1, |
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| Gene summary | | The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development. [provided by RefSeq] |
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| Location | | Chromosome: 17 Locus: 17q23.2 |
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| Gene position | | 58677554 - 58742036 Map Viewer |
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| Gene orientation | | plus |
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| Gene size | | 64483 bp |
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| Gene sequence |
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| OMIM ID | | 605100 |
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