| Entrez gene ID | | 8412 |
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| Official gene symbol | | BCAR3 |
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| Full name | | breast cancer anti-estrogen resistance 3 |
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| Aliases | | ,KIAA0554,NSP2,SH2D3B, |
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| Gene summary | | Breast tumors are initially dependent on estrogens for growth and progression and can be inhibited by anti-estrogens such as tamoxifen. However, breast cancers progress to become anti-estrogen resistant. Breast cancer anti-estrogen resistance gene 3 was identified in the search for genes involved in the development of estrogen resistance. The gene encodes a component of intracellular signal transduction that causes estrogen-independent proliferation in human breast cancer cells. The protein contains a putative src homology 2 (SH2) domain, a hall mark of cellular tyrosine kinase signaling molecules, and is partly homologous to the cell division cycle protein CDC48. [provided by RefSeq] |
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| Location | | Chromosome: 1 Locus: 1p22.1 |
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| Gene position | | 94147385 - 94027348 Map Viewer |
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| Gene orientation | | minus |
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| Gene size | | 120038 bp |
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| Gene sequence |
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| OMIM ID | | 604704 |
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