| Entrez gene ID | | 8405 |
| Official gene symbol | | SPOP |
| Full name | | speckle-type POZ protein |
| Aliases | | ,TEF2, |
| Gene summary | | This gene encodes a protein that may modulate the transcriptional repression activities of death-associated protein 6 (DAXX), which interacts with histone deacetylase, core histones, and other histone-associated proteins. In mouse, the encoded protein binds to the putative leucine zipper domain of macroH2A1.2, a variant H2A histone that is enriched on inactivated X chromosomes. The BTB/POZ domain of this protein has been shown in other proteins to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes. Alternative splicing of this gene results in multiple transcript variants encoding the same protein. [provided by RefSeq] |
| Location | | Chromosome: 17 Locus: 17q21.33 |
| Gene position | | 47755525 - 47676246 Map Viewer |
| Gene orientation | | minus |
| Gene size | | 79280 bp |
| Gene sequence |
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| OMIM ID | | 602650 |
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