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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for CAPN6 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID827
Official gene symbolCAPN6
Full namecalpain 6
Aliases,CANPX,CAPNX,CalpM,DJ914P14.1,
Gene summaryCalpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. The protein encoded by this gene is highly expressed in the placenta. Its C-terminal region lacks any homology to the calmodulin-like domain of other calpains. The protein lacks critical active site residues and thus is suggested to be proteolytically inactive. The protein may play a role in tumor formation by inhibiting apoptosis and promoting angiogenesis. [provided by RefSeq]
LocationChromosome: X   Locus: Xq23
Gene position110513774 - 110488327  Map Viewer
Gene orientationminus
Gene size25448 bp
Gene sequence
OMIM ID300146