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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for TCL1A (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 8115 Official gene symbol TCL1A Full name T-cell leukemia/lymphoma 1A Aliases ,TCL1, Gene summary Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR)-alpha (MIM 186880) or TCR-beta (MIM 186930) regulatory elements (summarized by Virgilio et al., 1998 [PubMed 9520462]). In normal T cells TCL1 is expressed in CD4-/CD8- cells, but not in cells at later stages of differentiation. TCL1 functions as a coactivator of the cell survival kinase AKT (MIM 164730) (Laine et al., 2000 [PubMed 10983986]).[supplied by OMIM] Location Chromosome: 14   Locus: 14q32.1 Gene position 96180533 - 96176304  Map Viewer Gene orientation minus Gene size 4230 bp Gene sequence >TCL1A:complement(77176304..77180533):Length=4230 GTCCTCCCGCCCCGCCGCTTGGTGGCGGCCGCATGCTGCCCGGATATAAAGGGTCGGCCC CACATCCCAGGGACCAGCGAGCGGCCTTGAGAGGCTCTGGCTCTTGCTTCTTAGGCGGCC CGAGGACGCCATGGCCGAGTGCCCGACACTCGGGGAGGCAGTCACCGACCACCCGGACCG CCTGTGGGCCTGGGAGAAGTTCGTGTATTTGGACGAGAAGCAGCACGCCTGGCTGCCCTT AACCATCGAGGTACAGCCAGCTTTGGAGCGGATGGCGAGGCAGCAGGGGCAGCCCCTGGG AGCTTGGGATGCCCTAGGAAGGGCGAGGACTCAAGGAGCACTCACTATGGGGCAGGGAGG ATCCCCACAGATGAAGCCACTTTGAGCCGGGCTCTGGAGGATGAATAGGAGTTCTCCAGG CAGGGAAGAAGGGTGGGAAAACCGCAAAGGAATGTCGGTCAAAGGGGTGGACCCAGTGCC TGTGGAGTGTGACTATAATGTTGACTACAGCAGGCATTTTCTGGGCTTCGGGGTCCTAAT CCTTAAAAATGGGTATCTCTAAGTGACTCATCCATATGGCCGATTATCGGAATCATCTCA GGTGGGTCCCAGAAATCTGTATTTTTAAAAAGAACCCTCAACAGTTTAGGGTCAACCAGG CATAGCAAACACTGGCCTAGAGTGTGAAGTATTTTCCACTACCTCTGGGCTTTATTTAGA AAACAAATTTAACAAGTGATGTCGTAGTATAAGCGCCGGTATTGAATCAATATTGACTTT TTTAATGTGTGATGCCTTAAGATGGGTCCTTAATCCATGTTAAGTTTTTGTTAAAGAAAT AGATAAGTCTTTTACAAGTATTTGGATTTACTCAATGAAAAAGAGTCAAAAAATGTTCAA ACTCTCTCCAAACATACACTGAAGAAAGCATAAAAATTAAAAAATATATTAGAACACGTA TGTCCAGTAGCAATCAAAAATTATTGAGTGTTGACTGTGTCTCTACAGATGGGAAACTGA GGCACAAAAATGTACATTTGTCCGAGGTAAGATTGCTAGTAGGTAATGGGGTTGGAATTC TAGGCTCTTAACCACCACAAAATCTGCATTTTTATTGGCATTTCAATTTTTTAAATATGT TTTTACTTTAAAAATCAAGTTAAATACTTACTTTTTTAAAATCAAAATTTGAAGAAATAA TTTGAAGATTCAGTGGATTTCTTTTTTTAAATCTCTGAGAAATCTCTTCTTCAACGTGAC ACCAAAACCACGAACCAGACAGTTTTTCATAAAATCATGATACATGCTCCACAAAAAATA ACCCACTAGCAAACTGTGGGACAGATTTTGCCTCACATCATTGAAAAGGCCAGTATTCTT TTTCTCTCTTTCTTTCTTTGTTGTTTTTTTTTTTTCCTGTAGATACAGGGTCTCGCTCTG TGACCCAGGCTGGTCTTAAACTCCTGGCCTCAAGCGATCCTCCTGCCTCTGCCTTCCAAA GCACTGGAATTACAAGTGTGAGCCGCTGCAACCCGCCAGAAAAAAGTGTGCCTTTCATGG CCCTGTCTGGGTGGCTAGACACGTGTGTGTGCTGGTGGTCCTGGCCCAGCCAGAGTCCCT GAGAGGAGCATGCATGGCCTAAGGAAGTGAGCTTCAGGGAACAGTGATGACCATCATTTC ACACTCGGACCCCTGCCCAGATGGGTGGATGGCTGGCAGGAGGGATTCCGGTTTTCTGCG CCTGGAGAAGCCCTGGCAAGCGGAACCTGAAAGTATGCCCTGTCCTTTTCTTCTCCTCAG ATAAAGGATAGGTTACAGTTACGGGTGCTCTTGCGTCGGGAAGACGTCGTCCTGGGGAGG CCTATGACCCCCACCCAGATAGGCCCAAGCCTGCTGCCTATCATGTGGCAGCTCTACCCT GATGGACGATACCGATCCTCAGACTCCAGTTTCTGGCGCTTAGTGTACCACATCAAGGTG AGTGTCTTTCTCCCAGAGGTCCATCGGGTGATCTTGGGTTTGCCCTCCTCCATGTCTGGC CTTAGTGGTTTATCTTCCCTCCATCCCAGTCCCAAAAGCATTAAAAAATGGGGGAAATGT ACAAGTGCAGATTTCTAAAGGACTTTACCAGAGAGAAGATAGATCCTCTGAGGTCTCTAA CAGAACCCTACCTCCACTTCCTCCCAGCCACCAGCTAGCCGCAGGAAGACATCTCTGGTG GGCAGTCACAGGCTGAAGGCTGGTGGGAGGAGGGGCAGTCTCCAAGAGCCCCTGAAATCC TCACACCTGGGTTCCTACCTGCTGTTTCCAGCTAGGGGAAGGCGCAGGAGTGAGGAATGG AGGGAGTGGAGGGCTCTGGCCGATCAATGCCTTCTCTCTCTCTCTGCCTCTCAGATTGAC GGCGTGGAGGACATGCTTCTCGAGCTGCTGCCAGATGACTGATGTATGGTGAGCTCCACT GGAGCCTGACCCCTCTTAGTCCACAGTGGCTGTATCAGAAAGAAAGACCACCCCTTCTCC ATGAAGGCAGTGCTAACCCCTCCCCGACTGCTGCCATCTGAGGGTCCCTAGGGATGGGAG AGGCTTCCTGGAGGCACTCATGTCTCCCTTACCACTTCGGGAGCCAAGGGCTTTGTAGGC AGCCCCCTTTATCGCAGCTGCTCATATCTATAAAGTACTTCACAAGTTTCAGCTGGCACT TTCATTTACCATTGCTTTTTTTTTTTTTTGAGATGAGTCTGGCTCTGTGGCCCAGGCTAG AGTGTAGTGGTGCAATCTCAGCTCACTGCAAGCTCTGCCTCCCGGGTTCACACCATTCTC CTGCCTCAGCCCTCGGAGTAGCTGGGACTACAGGCGCCCGCCACCACACCTGGCTAATTT TTTTTTTTTTTTTTTTTTTTTAGTAGAGACGGGGTTTCACCGTGTTAGCCAGGATGGTCT CGATCTCCTGACCTCATGATCTGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCA TGAGCCACCACGTCCGGCCTTACCATTGCTTTATTAAATAAGCACTGGTGCTTGATTATA TCAGCTGAGCCAGATATTAGATACGCTATTGAGTTTTGAGGAAATAAGAGTACAAAACTC AGAAATGAGTTGAAGTATAGTGACATCTTCAGATTACAGACCCAGGTGTCAGAATTTGCC TTGGCTCAGAAGGCCTCTGGGGGCCATCCCTGACCACTAGGCTTCCCACTTAGACCTGCT CCAGCAGCACCACCCCTCGCCACTGCCTGGTCCTTTCCTTCACCCTTGATTCTGTCTTCT TTTGTCCTTCTCCAGGTCTTGGCAGCACCTGTCTCCTTTCACCCCAGGGCCTGAGCCTGG CCAGCCTACAATGGGGATGTTGTGTTTCTGTTCACCTTCGTTTACTATGCCTGTGTCTTC TCCACCACGCTGGGGTCTGGGAGGAATGGACAGACAGAGGATGAGCTCTACCCAGGGCCT GCAGGACCTGCCTGTAGCCCACTCTGCTCGCCTTAGCACTACCACTCCTGCCAAGGAGGA TTCCATTTGGCAGAGCTTCTTCCAGGTGCCCAGCTATACCTGTGCCTCGGCTTTTCTCAG CTGGATGATGGTCTTCAGCCTCTTTCTGTCCCTTCTGTCCCTCACAGCACTAGTATTTCA TGTTGCACACCCACTCAGCTCCGTGAACTTGTGAGAACACAGCCGATTCACCTGAGCAGG ACCTCTGAAACCCTGGACCAGTGGTCTCACATGGTGCTACGCCTGCATGTAAACACGCCT GCAAACGCTGCCTGCCGGTAAACACGCCTGCAAACGCTGCCTGCCCGTAAACACGCCTGC AAACGCTGCCTGCCCACACAGGTTCACGTGCAGCTCAAGGAAAGGCCTGAAAGGAGCCCT TATCTGTGCTCAGGACTCAGAAGCCTCTGGGTCAGTGGTCCACATCCCGGGACGCAGCAG GAGGCCAGGCCGGCGAGCCCTGTGGATGAGCCCTCAGAACCCTTGGCTTGCCCACGTGGA AAAGGGATAGAGGTTGGGTTTCCCCCCTTTTATAGATGGTCACGCACCTGGGTGTTACAA AGTTGTATGTGGCATGAATACTTTTTGTAATGATTGATTAAATGCAAGATAGTTTATCTA ACTTCGTGCGGAATCAGCTTCTATCCTTGACTTAGATTCTGGTGGAGAGAAGTGAGAATA GGCAGCCCCCAAATAAAAAATATTCATGGA OMIM ID 186960