| Entrez gene ID | | 790 |
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| Official gene symbol | | CAD |
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| Full name | | carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase |
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| Aliases | | ,-, |
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| Gene summary | | The de novo synthesis of pyrimidine nucleotides is required for mammalian cells to proliferate. This gene encodes a trifunctional protein which is associated with the enzymatic activities of the first 3 enzymes in the 6-step pathway of pyrimidine biosynthesis: carbamoylphosphate synthetase (CPS II), aspartate transcarbamoylase, and dihydroorotase. This protein is regulated by the mitogen-activated protein kinase (MAPK) cascade, which indicates a direct link between activation of the MAPK cascade and de novo biosynthesis of pyrimidine nucleotides. [provided by RefSeq] |
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| Location | | Chromosome: 2 Locus: 2p22-p21 |
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| Gene position | | 27440258 - 27466654 Map Viewer |
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| Gene orientation | | plus |
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| Gene size | | 26397 bp |
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| Gene sequence |
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