| Entrez gene ID | | 7409 |
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| Official gene symbol | | VAV1 |
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| Full name | | vav 1 guanine nucleotide exchange factor |
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| Aliases | | ,VAV, |
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| Gene summary | | The protein encoded by this proto-oncogene is a member of the Dbl family of guanine nucleotide exchange factors (GEF) for the Rho family of GTP binding proteins. The protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. This particular GEF has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. [provided by RefSeq] |
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| Location | | Chromosome: 19 Locus: 19p13.2 |
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| Gene position | | 6772722 - 6857371 Map Viewer |
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| Gene orientation | | plus |
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| Gene size | | 84650 bp |
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| Gene sequence |
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| OMIM ID | | 164875 |
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