| Entrez gene ID | | 7408 |
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| Official gene symbol | | VASP |
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| Full name | | vasodilator-stimulated phosphoprotein |
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| Aliases | | ,-, |
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| Gene summary | | Vasodilator-stimulated phosphoprotein (VASP) is a member of the Ena-VASP protein family. Ena-VASP family members contain an EHV1 N-terminal domain that binds proteins containing E/DFPPPPXD/E motifs and targets Ena-VASP proteins to focal adhesions. In the mid-region of the protein, family members have a proline-rich domain that binds SH3 and WW domain-containing proteins. Their C-terminal EVH2 domain mediates tetramerization and binds both G and F actin. VASP is associated with filamentous actin formation and likely plays a widespread role in cell adhesion and motility. VASP may also be involved in the intracellular signaling pathways that regulate integrin-extracellular matrix interactions. VASP is regulated by the cyclic nucleotide-dependent kinases PKA and PKG. [provided by RefSeq] |
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| Location | | Chromosome: 19 Locus: 19q13.2-q13.3 |
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| Gene position | | 46010688 - 46030241 Map Viewer |
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| Gene orientation | | plus |
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| Gene size | | 19554 bp |
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| Gene sequence |
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