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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for UMOD (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 7369 Official gene symbol UMOD Full name uromodulin Aliases ,ADMCKD2,FJHN,HNFJ,HNFJ1,MCKD2,THGP,THP, Gene summary This gene encodes uromodulin, the most abundant protein in normal urine. Its excretion in urine follows proteolytic cleavage of the ectodomain of its glycosyl phosphatidylinosital-anchored counterpart that is situated on the luminal cell surface of the loop of Henle. Uromodulin may act as a constitutive inhibitor of calcium crystallization in renal fluids. Excretion of uromodulin in urine may provide defense against urinary tract infections caused by uropathogenic bacteria. Defects in this gene are associated with the autosomal dominant renal disorders medullary cystic kidney disease-2 (MCKD2) and familial juvenile hyperuricemic nephropathy (FJHN). These disorders are characterized by juvenile onset of hyperuricemia, gout, and progressive renal failure. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same isoform. [provided by RefSeq] Location Chromosome: 16   Locus: 16p12.3 Gene position 20364037 - 20344373  Map Viewer Gene orientation minus Gene size 19665 bp Gene sequence >UMOD:complement(20284373..20304037):Length=19665 AGACTAACTCTACCTTTCTGGCTTCAGGTAAGGCTATCTGTAGCTGTCTTCTCCTAGCCC AGCTTCTCCCCATCCTATTTGAGGGAGGTAGGAGAGGAAATTAAGACCTTGGACACTGGG GTCAGACCTGGATTTGAGTCATTATTCTGCCAATTATTGGCTTCATGATCTTTAGTAAGT TAGTTTTCCTCTCTTTGATCCTCTCTGTCCTAGTAACAATGACTACTATTTTTTGACTTA TTCCATGAATATTAGTTATGCACCTATTATGTGCCAGGTACCAGGGTTACAACAATGAAC AACTTGCTATGTGCTGGGCCCTGCTCGACATATGTCATCTTAGTTAATCCCAGTGACAAT ATGCAGTGTTTTAGGTCGCATCTTATTAGCGGGTCATAAAATCATTCCTTTTGTGGGTTA TATCCAGGGACTTCTTTTAATTAAATATAATAGAATATGTCAGTAAGCAATACAAATTTG AGGCAAGCAGTTAGCCTCTTTGTCCCCCTGTTTTCTCATCTGCAAACTAGGATAATACTT ATCTCATAGGGTTGTGGTAAGAATTAAATCACTTAATGTAGTAAGGATATCAATTGTCTT ATAAAATTTTATGTGTGTGTGCACATACATGCAGAAGCGACTGCACTAGATCATGACATA AAATGTTTTTCTTTCTTTCTGTCTTTTTTTTTTTGGGGGGGGGGGATGGACTCTCTGTCA CCCAGGCAGGAGTGCAGTGGCACGATCTCAGCTCACTGCAACCTCTGCCTCCCAGGTTCA AGCAATCCTCCTGTCTCAGCCTCCCGAGTAGCTGGGATTACAGGCGCCCACCACCATGCC CGGCTAATTTTTGTATTTTTATTAGAGATGGGGTTTCACCATGCTGGCCAGGCTGGTCTC AAACTCCTGACCTTGTGATCCACCCCCTCAGTCTCCCAAAGTGTTGGGATTACAGGCATG AGCCACTGCACCTGGCAACATAAAATGTTTTTCTTTTAGTACATCATGGTCACGAAGATC TGGAAAACGTTGCTCTAGGACCCAATGCCTTTGAGCACATGAATGTCTTTGAACTGAGCC TGGCCCATCATAGATATTCAGTTTGTGAAAGCAACAATCTCCATTTCACAGACAAAAACG GAGACTTAGTAAACTGAAATACCCACATCACAGTGTTAGTGATCAGTAAAGCAGGGATTT GAACCTCAGGTGCAGGCTGCAGCTCCTACATACTTAACCAACATGCCACCCTATTTTGCT GCTATAAACACTGGGGTAATACTGGCATCCACCCTGGACTATTTTTCCAATTGGAAGAAA TAGTAAGTGACCACTCCAGAAACATTTAAATGCATTGTGAAGGTTAATTACCTCTCAAGT TGCTCGTCTCAAGCCACTTCTTTACGATATGTGAGTTGCATGAAGGAGCAGACTGCCATG TTCATTGTTCTCCATGGTGACTAGCTCCCTGTTTGGCACAATGTAGCTACTCAATAGATG TTTGTTGAATGAATAAGTGATCCAGGCAAATTGAAAGTTTCCAGGCAGAGGATCAGTTAA AATCCAAAGCTGCCTTCAGTAAAGTGGTGAGTCCAGAACACTATTCCATCTGGCTACTTC CTGCTCCAAATGACTGAGTTCTTCAAAATGTGCAATGTGCTGAGAATTGGGGAGCCAAGA CTGGGATGTTGGTGAGGTAAGGAGGGGGAGTACAAGGGGTAAAGTCCCAGCAAAACAAGG GCTGCAGTGTTATGCAATTTTTTAGTCCATATAAGTGACACCTCCTGGAGTTGTATACTA TACAATCAAAGCACTCCTTCCAGCTGTGGGGAGGAGAGTTAGATCATGCATTTGTCCCAT CCATCTCTGTTCACAGGACACCAGACATCAGAGACAGAGAGAAAAATTCAAAGGGCCAAC CCGTCTTTCCTTTGGGCAGGTGCTATCTAGACCTGAAGTAGCGGGAAGAGCAGAAAGGAT GGGGCAGCCATCTCTGACTTGGATGCTGATGGTGGTGGTGGCCTCTTGGTTCATCACAAC TGCAGCCACTGACACCTCAGAAGCAAGTAAGTGAAAAGTGTGTGTGCGTTGTATATGTGT GTATGCACGTGTATGTGTGAATGTGTGGGGGAAGCAATGTAGCACCTGTCAGAGGTGATC TCAATCCTCCTATCGCACTTGAGACTTGCATTGTCTTCATTCTAAGTCCATTTCTTAGAC TCAATATGCACAGGACTGACTTAGAAATTTTGCTAAAGTGCATATTCTGGTTCAGCAGAT CTGCAGTAGGACCTGAGATGCTGAATTTTTAACAAGCTTCCAGGCGATGCTCATACTGGG GTCCCTGGAGTACACATTGAAAAGCAAGGGGCTAGAACATCTCTAAGGCCTGCAGGCCCT TTATTGGAAGTCAGAAACATACTCTATCACATAGGAGATTTGAACCCATGCAGGAGGATC CAAACACCTTCCCTTTCAACTTTAAGAGGTCATTCCATTGGGTTGAGATTTGCTGTCACC CCACTTTCATTTTCTCCCTGGAGTACGTTGGGGCACGATGAATACTATTGCGGTGTCCTG GTTAAAAGCACATATTTTGTGGTCCTGCCATCTGCGTTTTTATCCTGGTTCTACTTCTTA CCAAAGGAGTAAGGGGCTTAATCCCTCTGAACCTCAGTCTCCTCATCTTTAAAATAAGGA TACATAAAAAACTGACCTCACGAGGCCCTTGGGAAGTATTCAACAAGATAGTGAGTGAAA AGTGCACATCCTATTGCCTGGCATATAGTAATTGCTTAATAAACAACAGCTTCTTTTTTT TTTTAATGGTTATTTTTATTACGGAGGAACAAAGTACAACTGCCCAGCCAGGTGGAGTTG GAGGACTCCGCAGAGAGGAGGCGACACTGAGCAGGGTCCTGATGAAGATTTCACCAGCCA GGGAAGCAGAAAACATAAAATGTGCAAAGAAAGGGAGGGGCAACAGGTTCACCGTAAATC CTACCAAAGTATAGGAATTCTGCGCATTACTTTTCTGAATGTGGCTATTTTAAAAGAAGA CAGCTTGAAAGCAATGCTTAACACAAAAAATGAATGGTGGAGCTGGGCGCGATTGCACGT GCCTGTGGTCCCAACTTTTTGGGAAGCTGAGGCAGGGTGCGGTGGTGGCTTGAACTCAGG GAGTAGAACGCTTGAACCCAGGAATTGGAGGCTATGGTGAGCTATGATCGCACTACTGCA CTCCAGCCTGGGCGACAGAGCAAGACCCCTCTCCAAAAAAATAAATAAAGTTAAAAAATA CAATGAAATAAACACAGAATGAACGGTGGAGGCTTGACATCATCAGAGGAGTTTTGTTTC TTTGCTTCTTTCCTTGTTTTGGAGGGAGCCCTCTAGGGAATAAGTCTTAAAAATAATGAG TTCCCTGGAGAATGAGGGAAGGATCTCTGGGTGGCCATGGGCCCAGCTGCCCAAACCCTG AAGCTGGGCTTTTCTGTCCACAGGATGGTGCTCTGAATGTCACAGCAATGCCACCTGCAC GGAGGATGAGGCCGTTACGACGTGCACCTGTCAGGAGGGCTTCACCGGCGATGGCCTGAC CTGCGTGGACCTGGATGAGTGCGCCATTCCTGGAGCTCACAACTGCTCCGCCAACAGCAG CTGCGTAAACACGCCAGGCTCCTTCTCCTGCGTCTGCCCCGAAGGCTTCCGCCTGTCGCC CGGTCTCGGCTGCACAGACGTGGATGAGTGCGCTGAGCCTGGGCTTAGCCACTGCCACGC CCTGGCCACATGTGTCAATGTGGTGGGCAGCTACTTGTGCGTATGCCCCGCGGGCTACCG GGGGGATGGATGGCACTGTGAGTGCTCCCCGGGCTCCTGCGGGCCGGGGTTGGACTGCGT GCCCGAGGGCGACGCGCTCGTGTGCGCGGATCCGTGCCAGGCGCACCGCACCCTGGACGA GTACTGGCGCAGCACCGAGTACGGGGAGGGCTACGCCTGCGACACGGACCTGCGCGGCTG GTACCGCTTCGTGGGCCAGGGCGGTGCGCGCATGGCCGAGACCTGCGTGCCAGTCCTGCG CTGCAACACGGCCGCCCCCATGTGGCTCAATGGCACGCATCCGTCCAGCGACGAGGGCAT CGTGAGCCGCAAGGCCTGCGCGCACTGGAGCGGCCACTGCTGCCTGTGGGATGCGTCCGT CCAGGTGAAGGCCTGTGCCGGCGGCTACTACGTCTACAACCTGACAGCGCCCCCCGAGTG TCACCTGGCGTACTGCACAGGTCAGCCGGAGTCTCCCCACAGTCCTCATCCCAGGCCTGG AAAGGCACTGCAGAGGACGGGGGTGCGTCCTTATTGATTGTCTGTCTGTCCCTGTGACCC TGCAGACCCCAGCTCCGTGGAGGGGACGTGTGAGGAGTGCAGTATAGACGAGGACTGCAA ATCGAATAATGGCAGATGGCACTGCCAGTGCAAACAGGACTTCAACATCACTGGTGAGGC CAGTGGGGAGGAAGCGGGTTGTTGAGAAACCTGTCACTGCCTGGGGGAGGGACACATTCC TCCCCTGTGAGATTGGGGCCATATGGGTATGACGCAGGGGATATATATCCAACCTGAGTG AAAACAGAAGATCCACTAATACCCATTAAAGCCGGCAAGAGGCTCTCTGAGGCTCCCTGA GTCTCCCTTTAGTTGACTTCAAAGCTGCCAAAGATTTGGGGACCTCCTCGCACCCAGCCT TCTTTCTGAGGCCCACACCACAGTGGGCACCCACGTTGCTGCCATCTGGGAGCCAAAGAC CATCTGAGCCCTATTCCTGCAGCACCAGAACACAAGCCCGGCCCGGTGAGCAGTCCACCA ATCAGCTCAGGCCTGATGACCAGTCCACCAATCAGCTCAGTACTCCGGGCCAGGCACAAG CCTCAGATTTCTCATAGGTACAATTATTGAAGATGAAAATAGTATTTTCAGACTTCAGTC ATGATTTTAGTTACATCCAAGTGCCAACTTTACAATTGGCACCCTGGTTCACTTGCTTTA TCCAAGTGTTACCTGTGCCATGACTTTTATTAAGTTGTTTTTCTTCTAATGGACTGAATC TCTTAAGCAAATTTGGAATGTTGATGGTCAGGACTTCATCTGTCTGTGGCAAGTTATGCT TACCTTAGACAGAAAGTTAACTGTAAAAATAAAAGTTACTAAAAAGAAAAGAAGGTTACT AAATTTCAGCAGTTGTGTAATACTTCCATAAAACAAATTTTAAAAAATAAATACTAAAAA TTAGAAAAATACTTCAATTTTTAAAAAATTAAACAAGAATTCTGGCTGGATGTTGTTTCC TGCCCCAAACTCTCAGCCCGAGGCCTGCTCTCTGTTTGAGAGGGAAGTTAGTGGGCCGGG CGCAGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCGCAGCGGGCAGATCACCTG AGGTCAGGAGTTCAAGACCAGCCTGGCCAACATGGCAAAATCCCATCTCTACTAAAAATA CAAAAACTAGGTGAGTCTGGTGGCAGGTGCCTGTAATTCCAGCTACTCGGGAGGCTGAGG CAGGAGAATCACTTGAACCCAGGATGCGGAGGTTGCAGTGAGCCAAGATGGCACCTCTGC ATTCCAGCCTGGGCTTGTCGCCGAAGAGAGAAACTCCGTCTCAAAAAAAAGAGAGAGAGA GGGAAGTTAGTGAGTACATGGCATTAAAGACATTAGTGGCAAGCTGGGACTGTCTCCTTG ATGTGAAAAGGGTAGAAAGTAATTGCAGCTTGCTTGCTTTTTCTTTCTTTCTTTCTTTCT TTCTTTCTTTCTCTCTTTCTTTTTTTTATTATACTTCACGTTCTAGGGTACATGTGCACA ACGTGCAGGTTTGTTACATATGTATACATATGTAACTTGCATCATCTCCTTTGGCTACTA TTACTACTGTGGGAGATGCGTATTCTCATTTTATAGACAAGGAAATTGACCTCTGGACCT CAAGTAATCTGTCTGCCTTGGCCTCCCAAAGTGCTAGGATTATAGGCATGAGCCACCGCA TCTAGCCTTTTTATTTTTTTAAACGAGTATTCATTGTTATTTAATGCTGGGACATCAAAA CCCCCCAAAACCGTCCTGCATTTGGTATATAACCCACATTTAGGGGAACCCAAGACTGAG TGGTTGGTCAGTGGATGTATCCATTGATGTCAGAGGTCCAATCTTGAGTCCCCATCACAT TGGGAGGGGACAGATCAGCTCAAGGCTATGCTGAGCACTTCCAGATGGTGGTCAGCCCAG CCAGCTGGACCTGGCCCCTGGGGATGTGCTGGGCCCCCAAGCTATAGACACACGTCCTCA ATCCCACCTAACCTGTTTCAGATATCTCCCTCCTGGAGCACAGGCTGGAATGTGGGGCCA ATGACATGAAGGTGTCGCTGGGCAAGTGCCAGCTGAAGAGTCTGGGCTTCGACAAGGTCT TCATGTACCTGAGTGACAGCCGGTGCTCGGGCTTCAATGACAGAGACAACCGGGACTGGG TGTCTGTAGTGACCCCAGCCCGGGATGGCCCCTGTGGGACAGTGTTGACGGTACGTCCTG GCCAGTGGGGGACAGAACCAGAGCACTGCCTGGTTCAAGCTTCAGCTCTATCACTTCCTA GTTATAGAAGCTTTGGGGAGTTATTTAGCCTGGCTGTGCCTCAGTTTCATCAACTGTAAA GTGGAGAAATAATAGTACCTACTCCACAGGTGTATTGAGAGGATTGAATGAGTTAATGTG TTGAAGTGATTAGGACAGTGACTGCACACAGTAAGTGCTCAATAAACATCAGCTTCAAAT AAAGAAAGCAATTCATGGTGATAGTTCTCCATTTTACAGATGGGAAAAGTAGGGCCATAG TAGGGATTGTCTCAGCCAGTAGGCATCAGCATTGGGTTCAGAAACTAGTCTATTTGTCTC CAGTGGTCCTGGAAGGCAAGGTCTGTATCCTTAATGTACAGAGAATCAGGACCTCACCTA CAGAGGCCTCCTCAAATGAAACCCAGAGGTAAATGTTTGTGTGAGCAGAGCATTATCTCC TGCCACCTCCCTCATTACCAGAGGAAGAAAGAAAGAGAAAGAGAGGAAGAAAGAAAGAGA AGGAAGGAAAGAAAGAAAGAAAGAGAAAAAGAGAGAGAGGGAAGGAAGGAAGGAAGGAAG GAAGGAAGGAAGGGAGGGAGGGAGGGAGGGAGGGAAGGAAGGAAGGAAGGAAGGAAAGAA AGGAAGAAAGGAAGAAAGAAAGAAAGAGAAAGAAAGAAAGAAAGAAAGAAAGAAAAAAAA AGAAAAGAAAGGAAGGAAGGAAGAAAGGAAGAAAGAAGGAAAGAAGAAAGAAAGAAAGAA AGAAAAAGAAAGATTTAATGTTGGCCGGGCATGGTGGCTCACGCCTGTAATCCCAGCACT TTGGGGGGCCGAGGCGGGTGGATAACTTGAGGTCAGGAGTTTGAGACCAGCCTGGCCAAC ACAGAGAAACCCCTTCTCTACTAAAAATACAAAAATTTGCTGGACCTGTTGGTGGGCACC TGTAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATCACTTGAACCCAGGAAGCAGAG GTTGCAGTGAGCCGAGATTGCACCACTGCACTCCAGCCTGGGTGACAGAGTGAGACTCTG TCCCAAAACAAACAAACAAAAAGAAATAATTCATGTCATTTTCCAAGGATGGCATTTGAA ATTCCATTGATGGTGACTTGGCATATGGTTTTCAGTTTTCAAGAGAGGAAGCACGGGGTG CTGAAAACAGTCTAGTCTTGTGAGATGTCACATATTGTGGGCAATCCCTCAGTGACTCTG TTACTATGAATCTCTGTCTTCTTGTCTGGGAAGCAGGGATGTGGCAGCGCCACTTGTTAG GGTCACTGAAGGAACTAATGCTATGACTCAGGAGGGGTATTCCACTCGGGGTCTGGCACA TGACATATGCGCATGAATGGTCATTGCTGTTGTAACTTTTTTTTTCTAATTTATAAAGAA AAGATGATTAATTGGCTCGTTGTTCAGGCTGCACAGGGAGTTTTTAACTGTTGTGGGATT TTTTTTTTTTTTTTTGAGATGGAATCTCCCTGTCGCCGAGGCTAAAGTGCAGTGGCACGA TCTTGGCTCATTGCAAGCTCTGCCTCCCGGGTTCAAGCGATTCTCCTGTCTCAGCCTCCC GAGTAGTTGGGATTACAGGCACCCACCACCACGCCCGGCTACTTTTTGTATTTTTAGTAG AGACAGGGTTTCACCATATTGGACAGGCTGGTCTCGAACTCCTGACCTCAGGTGATCCGC CTGCCTCGGCCTCCCAAAGTGCTGGGATTACAAGCGTGAGCTAATGCGCCCGGCCACAGG CAGCTTTTTATCAAGGAGACTAGGAGAGCGGCTCACAAGTAGCCAGACATGAGACCAGCA GATTTAGCTTTGAAGTCCTACTCAGATTCTCATGCCCCTTTCTCTCATCCCCACCCCCCC TCCACCCCCATTCCCTGCAACAGAGGAATGAAACCCATGCCACTTACAGCAACACCCTCT ACCTGGCAGATGAGATCATCATCCGTGACCTCAACATCAAAATCAACTTTGCATGCTCCT ACCCCCTGGACATGAAAGTCAGCCTGAAGACCGCCCTACAGCCAATGGTCAGGTGTGGCC AGAGAGGGTCCCTAGGGCCCCTAGATGGTTCTAACCCCAAACCCCTTAACCATGAGCTTC CCTGTCAACTGCCACCCACAGGGAGCTGGGAGTGAGGGCTGGGAATCAGGGTTGCCCAAT GGAAGAGCCAGGAATTCTGGAGCCCAGGTTCAAATCTAGACTTTGTCATAAATGATGGTT ATGCCCTGGCCAGTGGGGGACAGAGTCAAAGCACTGCCTGGTTCAAGCCCCAGCTCTGTC ACTTACTAGTTGTATGAGCTTGAGTGAGTTATTAAGCCTGGCTTTGGGAAATTGATAGTC CCTCTCTAGGTGTCAATATTTTCATCTGTGAAATGGGTTTAATAGTACTCTAAGAATTAA ATGATATGGGAGGATCGCTTGAGCCCAGGAATTTGAGGCTGCTTAGAGCTATGATTGTGA TGTGAATCAGATTCAACCATTAAACTGATGTAGATGATTCAGATGTGAATCAAATATTAA AGTCTCTACTTTTCAAAGAGGCAGGGTGGTTGTGCCAGAGAGCAGGAATGGTCTCAGTCC AGACTGCTATGGAATGCTGGGCAAATCATATTTCATATTTGGACCTCAACTTCTTTCCTT CTCTGTGAATGAAAGGAATTTGATTAAAGAGGATTTTAAAAATTACGCTCCTTGCAAGTG TCTTGGTAGGGGCCAAGGGAGGTGCCCTGGCAGAGTGCCTACAGGGGTAAACTATTCATA CTGGGTGCCACGTAGTATTTTATTTTATTTTTTTTAAAAGGAATCTGTTGCTAAATAAAA TTGAAAATCTTCAAATAGGATGAATCACAGGCCAATGATGGAAAATTATAGTTGTAATAA GAAATAAGATTTATTGATTATTTATTTATTTATTTATTTATTTATTGAGACGGAGTCTCG TACTGTCGCCCAGGCTGGAGTTCAATGGCATGATCTTGGCTCACTTCAACCTCCGCCTCC CAGGTTCCAGTGATTCTCCTGCCTCAGCCTCCCAAGCAGCTAGGATTATAGGTGCCCACC ACCACACCCAGCTAAGTTTTGTATTTTTAGTAGAGACGGGGTTTCACCATGTTGGCCAGG CTGGTCTCAAACTCCTGACCTCAGGCAATCCACCCACCTCGGCCTCCCAAAGTGCTGGGA TTATAGGTGTGAGCCACCGTGCCCTGCCAAGAACTAAGATTTATTGAGAGCTTACTATAT CTCAGGCATTATAGCCAGTGTTCTGCCTGGAACATCTCATCAAACTCTTACAGCAGCCCT AGGAGATAAAGGTATCATTATTATTACTATTCCCATTATACTGATGTGGAAATTGAGGCT CACAGAAGTTTGAGTGACTTACCCAAAGCTGTAAAGTCTAGCAAGTGATAGAGCTGGGAT TCAGACATCAGGTCCAGAGCCTCCACTTGACCATGACCTTCCCTTCGAAGCTTGCCCATG GTTTTCTGCTCTCTTGGCCAGCCAGACTCAGGAAAGGATGCTGGGCACTGATGAGGGTGC ACAGCTGACTTGGAGGAAGAAGAGTGCTCATTGCAAGCTGTTGGCTGGAACCTCACCTGG CCTAGCAGTGTCCTGGAGCAATGTGGCCCCGTCCTCGGCCTGGTAGGCTCTGGGGAACAA CAAGTGTGCCCACATCTCTCTGTTTTATGGTTTTGTTTTGTTACGAATCCAGGTCTCACT CTGTCACCCAGGCTGGAGTGCAGTGGCACAATCATAGCTCAATGCAGCCTCAAATTCCTG GTCTCAAGCAATCCTCCCACCTCAGTCTCCCAGGTGGCTAGGACTACAGACACATGCCAC CACACCACCCTGGGCTATTTTTAAAAATATTTTTATAGAGACAGGGTCTTGTTACATGGA CCAGGCTAGTCTTAAACTCCTGGCCTCAAATGATCCTCCTGCGTATGCCTCCTAAAGTAT TGGGATTACAGGCGTGAGCCACAGCACCTGGTCCCTCTCTCTGTCTCGAGTTAGACATCT CACCCCAGTCTTCACTGATAACTCAGTTCTCATCTGTAAAATGGACTTCCACATTTCGGA GTATTTCTCATGTGCCTTATTTCATGAGGCATCAGCCTTACAATGTCCTTTGTTGGATCA TCCAGTGAAGTTCACATCAGTGTGGCTGTTTTCAGTGTGGTTAAAAATAACTCATTTATA AACCTCAATCTTCTGATATAGATGTTAGTACATCACGATGGAGGCCAGGACGCAAGTTGT AGGCCTCATCATAGCTCAATACCTTTTAACCTGTTCTAGATTGAGACCAAAGAAGGAATC CAGGTGTTCCTGTCAATAATTTGTTTTTTTGCCATCTTGAAAGCTACAGGGGTAGCAAAG CCTATAGCAGTAGCAAGTGAGGGACTGGATGTGTTACTTGAGATGTGATTGATCCATAGA CCAGCAGCATCAGCAGCATCCAGGCACTTGTCAGAAATGCAGGACCTTGAGCCCCACCCC AATACTCACCAAATCAGAGCCTGCATTTTATCTAGATCCCAAGTTGACCTGCGTGTACTT ATTGCGGTTTGCAAAGCAACAGTTGGTGGGTTCCACTCTTATTGCTGGATAAAAATGCAA ATAACTGCAAGGGACTGCCTAGGAATGCAAATCAGAGAAGGTGGCCTATCTGCAGATGTT CTCAGCCCGGTCCTCTCACCAACCCTTCTCCCCTGGCAGTGCTCTAAACATCAGAGTGGG CGGGACCGGCATGTTCACCGTGCGGATGGCGCTCTTCCAGACCCCTTCCTACACGCAGCC CTACCAAGGCTCCTCCGTGACACTGTCCACTGAGGCTTTTCTCTACGTGGGCACCATGTT GGATGGGGGCGACCTGTCCCGATTTGCACTGCTCATGACCAACTGCTATGCCACACCCAG TAGCAATGCCACGGACCCCCTGAAGTACTTCATCATCCAGGACAGGTAAGGCAAAGGTTC CTACATGGGAACTCATGGGTAGAATTCAGAGGGGGTCTTTGGACTTGGATGGAGGAAAAT TGCATCTTTTTTTTTTTTTTTTTTGACAGAGTCTTGCTCTGTCGCCAAGGTTGGAGTGCA ATGGTGTGACCTCGGCTCACTGCAACCTCCGCCTCCTGGGTTCAAGTGATTCTTCTGCCT CAGCCTCCCAAGTAGCTGGGATTACAGGCAGAGGCCAGCAGGCCTGGCTAATTTTTGTAT TTTTAGTAGAGATGGGGTTTCACCATGTTGACCAGGCTGGTCTTGAACTCCTGACCTCAA GTGATCCACCCCCTTGGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACCACGCCTG GCTGAAAAATTGCATCTTTATATTCATTACCCTTTAGCTGAACCTTAGCATTCCCATCCA TTATAAATACAGGCAACAAACTACAGAAATATTAGCAGGTCGTGTGAAGCCATTTATAGT CATCAGTACTTTTTAGTTACTATAGCATTAGAATTTTCACTAGACCTTATTATTTAATGA ATTATCAATACATATGTATTGGCAAATATATATTTATGTATTATATATATATATATATAT ATACACACACACACATATATATACACACACACACACAAAGATATAATGCATTTTGTATTT CAAATGTCTTTTTTTTTGGTCGTTTGATTTGGTTTGGTTTTTTTGAGACAGGGTCTCATT CTGTCACCCAGGCCGGAATACAGTGACTTGATCATAGCTCACGGCAGCCTCAACCACCCA GGCTCAAGCGATCCTCCAGCTTTAGCCTCATGAGTAGCTGGGACTACAGGCACACACCAC CATACACAGCTAGCAAATGTTTTTAATATTTTGAGAATGGTGCTTCAATTTAATTGATTT CCTTTATAATCTTTTAAATATTTTATTTTAGGCATTTAAAAGTATTATTTCTGAGGAGGG ATGTACAAGCTTCACCAGAGAGCTGAGTAGGGTTTATAATTCAAAAAATGGTAAGAAACT TGATGGAAAGGCTTGCCCAGGGCAGCAGGCAGCCCAGCACCTGGGGGAGGAGTAAGACAT GGGCATGGTTAGCCAAGGGCCAATTGAAACTAGGACACAAGTGTGCTACCTTTTACTCAA GAGGCACTAGATGACTATGAACCTTACCATGAGACGGTGATTCACTTTCTCGTTCATAAG TTGAAAAGATATTTTGGAAGCTTGCTGTGTGTCGGGCTCTGTGGATTTCACAGTAAATAG AAGAAACAAAAACCTCTGCCCTCACACAGCTTATATTCTAAAGGGGGAGGGCCAACTATT AAATGAAAGTGAAATATATAGTATGTTAATGACAAAGAGGTTGTAGAAGAAACAAAGCAG GAGAAGAAAGACATTTGCAATTTTAATTGCATTGTCAGAAAAAGCATTCCTGAGAGACAG TGGTCTGTTTCTGCCTGGTTACACCAAGGGAATATTTTCAGGTGAGTGCCAATGTGATGT TCACACGTCTTTGGAATCTCCCTTTGCAATAAAAATAAAGCAGAAGTCTGTTTCAGAGCA TTTTGCAATTAGCAGAGTCTAACTCAAACTTAATACAACTCTTTTGTTGATCTTGTCCTC ATTGTATGGTCCTGTTCTATTTATGCAAGTGATACTTGTCTGCCATTTGAATTCATGACC TAAAGATTCTTCTAGTAAGTAAATGTATTTCAGTAAAAAATACAAGTGGATTTAAAGAAA AATAGTAAGTAAATAATAATACAGATGTTGGGACACACAGGAAAACGCTCATAAAGGTGG TATCTCAATAAAGAAAAAAAGAACTGAAAGTTGGAAACTGTTGGCATGACCTTGATTGGA GTATCACAGAGATTTGGGTTCAAATCTTGGCTTTGCCATTTCTTAGCTTTAAGAAACAGG TTAGCTCATCTCTCTGGGTTTTTCTATTCTCAGACGTAAATGGGGATAAATAATACCTGC TATGCTGGGATTTTAAAACTTGTTTTTCATGAGTATAACGGGCACGATGGCTCACGCCTG TAATCCCAGCACTTTGGGAGGCTGAGGCAGGCAGATCACCTGAGGTCAGGAGGTCAAGAC TGGCCTGGCCAATACAGCAAAGCCCATCTCTACTAAAAATACAAAAAAATTAGACAGGCA TGGTGGTGGGCGCCTGTCATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATTGCTTGAA CCCAGGAGGCAGAGGTTGCAGTGAGCCAAGATCACACCATTGCACTCCAGCTTGGGCAAC AAGAGTGAAACTCTACCTCAAGAAAATAAAAATAAAGCATAGCAGGGAGGCCGAGGCAGG TGGATCACGAGGTCAGGAGTTCGAGACCAGCCTGGTCAACATGGTGAAACCCTGTCTGTA CTAAAAATACAAGAATTAGCCAGGCATGATGGCACACACCTGTAATCCTAGCTACTCAAG AGGCTGAGACAGGAGAATTGCTTGAACTGGGAGGCAGAGGTTGCAGTGAGCCAAGATCAC ACCACTGCACTCCAGCCTGGGTGGCAGAGCAAGACCCCATCTAAAAATAAAATAAAATAA AAGTACAGCAGGGACATTGCGGAAAACTTGGAAAGTTTTGAAAAAGAAGCAGGAAAAAAT GTAGGGTGTGTCTATAAGTTGCCATCTGGGTGAGTGTGGGAGCTGGGGTGAGAACTACCA GTGTAGGATAGGTGTCAGAACATCACAAGGCATGAAAAGAGGAGACAAGTCGGGGAGACA GTGAAAGTGACTGGAGGGGACACATGGATGTCCAGGTTGGCTTGAGCACGTGGAGCCCTC ACAGGCCATACTGTCTGCCTTTCAGGAGTTGAGTCCACTTAACCTCAGGGCTTTTCTCTT GCCAGGCAGAGTCTGCACTTTTGGAGCCAGATCTGAATTATGGGAGACACAGAGCTAAGA GTGAAAAACACTCCCAGAAGCTCCCGTCTCAGTTTTGCAGTCAGTGTTCAGCCTCCCTCC GAAATCAACTTTGAGGAAAGAGTGCGGAATGGCAGAGGGGGTGCCCAGTTTGCCTCCCCA GAAAGCCTATGGGTATCCTGACCCAGCCCAGCACATGTGGGAGTCTCTGCATGCTCTATT TCGGGTTTCTCCTTCTAACTGTGTTTGGGTGCAATTGTGTATACGTGCAGATGGGTGCAC ACACTCCAATTTCATCAGTGGCTCTCGGTACCCAGAGGTTTCCATTGTTATAATTATACC AGGCATATTGTAGATAGCACATAGCAGCTAATAATTTTTGAATGTCATTGCTGGGAAATC AGGAAGTGCTGACTTTTGGATAGTTTCAGCTCTGCACTGATGACAGTTTCACTTTAGTAT CAAATATATAAAGCACCTATGGCATGCTACACACAGTTCTACGCACTTTGAGAAATTAAC GAATTTAATCCTTACAGCTATCTTATCACATGGGCTGCGATCATTTCTTATGTACAGATG GAGAAATTGAGGTACACAGAGATTAAATAAGTTGCCCAAAGTCACACAGCTGAAAGGTGA CAGAGCAATATTTGAATCCAGGAAGTCTGACTCCAGAATCTTTATTTAACCAACCACATT AAATGATGTGTAACCCTCCCAGATGCCCACACACTAGAGACTCAACTATCCAAGTGGTGG AGAATGGGGAGTCCTCCCAGGGCCGATTTTCCGTCCAGATGTTCCGGTTTGCTGGAAACT ATGACCTAGTCTACCTGCACTGTGAAGTCTATCTCTGTGACACCATGAATGAAAAGTGCA AGCCTGTGAGTTGACTCCCCTCCCCCAGCCCATCTCTTGTAACCAAAGACATTTGGCCAC AAAGAAAACAAATCAATATTTCTTCCCTGTTTCCCTCTTTTACCAGAGGGATAGAATGAG CAATAAGATGAGGTGGGCGTGGCTAGGCAGGAAACCTAAGCTGCAGGGGAAATCAGGTGG GATCAGTAAAGTGCGGCAGGCTGGTAAGAGCTCTGGCTTATCTGCAAGCTTGTGTTCAAA TAACAGGAGCTGACATTTTTAAGCACTGTGCCCACTTTATTTGTGTTAGCTTTTAATGCT TCACAGCAACTCTATAAGGGAGGTATTACTGGTTCCCTTTCCTCATGAGGAGAGGGGCTC AGAGAACTTCAGTGGCTTGCCTGAGATCATGCATCTATCTAACAAATGGCAGAGCTGGGA CCTGCACGAGCCCCGGTATACAGGTCTCCTAACAACTTCTGCCTGGGGCAAGGGAAGGCA CCTGTGAGGTGGGCAGTCCACTCCACGTGGCAGAACCACATTCAGGCTCCTTCATGGAGG GTGTTTTTCTATTGCCCTCTCCCTGTAGACCTGCTCTGGGACCAGATTCCGAAGTGGGAG TGTCATAGATCAATCCCGTGTCCTGAACTTGGGTCCCATCACACGGAAAGGTAAGAGAGC CACTCGCTCCTCAACATTCCTGGCTGGGAAAGATTTCTGGAGAGGAAGAGGGATAACAGA GCCTGGCACCTTGGCACCTTACTGAGCTCTGAAGAACTGGGAGCAAGTGGATCCTCTGGG GCAAGGTGGAATACAGACTGCCTTCCTTTCACTATTCCCATTCATACACCCATTCATTGG ACAAATATGATTTGTAGATGAATGTAACACAGGACACGGGGGAGGCCAGACAGGCAGGTA GGAATGTAGATCATCCAGACAAGTTTGCACACACATGAGGCCACAAACATACATTCATAT TTGTAGTAGATGTGTGCCTACTCTGTGTCTGGAGGTCTTGTGATGAGCAGAAGTAGATGG CCCTGCTCCCATGGAGCTTGTGAATCAGTGAAGAAGGTGCCATTTGAATAATCCCCTGTA GATGTGTAGGATCTGGGTGATCCATTAAGTGCAGGGTCTACAAAATATCTCAAGCACTGA TCTTAGGAGTGGTTTAGGAAGGGTCAGAATCTTGTGGCTTCCAGCTGCATGACTCCTAAA CCTTAATTTCTAATCTTGTAGCTAATTTCTTAGTTCTACAAAGGCAGTCTAGCCCCCAAG GCAAGAAGGAGGTTTGTTTTTGGAAAGGGCTGTTATCGTCTTTGTTTTAAACTATAAACT AAGTTCCTTCCAAATTAGTTCAGCCTACACCCAGGAAGGAACAAGCACAGCTTAAAAGTT AGAACCAAGATGGGGTTGGCTAGGTTGGCTCTCTTTCACTGTCTCAGTCATAATTTTGCA AAGGTCATTTCAAGAGTACAGCTTGGGCAAAGGGCCTGTGGCAGGAGGGAGCCTGGCCTG TTAAAGGAACCCAGAGAAGGCCAGGGGAGTTGTGTGGGATGAGCTGCTGCAGACCTTGTG GAGCCTTGCAGTTCTTGCTAAGGGTTGGGACCTTTCTCCTGAAAGCAGTGAGAGCCCCTG ATGGGTCTGAAGTAGGGGAGTAACATGATCAGATTTGGGTTTTGAAGAGATCAGTCTGGC TGCGAAGTGAAAAGTAGATTGAAGGGGTTTCTGTCAGGATGCTTGCCAAATCTCATGCAT TCTTTATTCACTGATCCTTCTGTTTTCCTCCAAAGGTGTCCAGGCCACAGTCTCAAGGGC TTTTAGCAGCTTGGGTAAGTTCAGGTCCTTTCTGCAGTGGGACCTGTTCCAGAACTCTCC TGGGGGGCTTCTATCTGTTAACTTGTAATGCTTCATAGCAACTCTATAAGGGAGGTGTTA CTAGTTCCGTTTTCTAAATAAGGAGAGTGGCTCAGAGAACCTGAGTGGTCCTACTGAGAT CATGCATCTCTCTATTAATTGTAAGAGCTGGGACATGTGCCCCAGTATACAGATCACTTA TTTTATACACAAACTTATTACAAACCCAAAGGATATGCACACACTCCAGATCTGCATCTT GGGCACTTACTGAAGCTCCAAGCCTCCTCTCTAACACTTTTTTCTAGATTCATTCAATAG GTGACAAATAGGCCAGGCGCAGTGGCTCACGCCTATAATCCCAGCACTTGGGGAGGCTGA GGCGGGCGGATCACAAGGTCAAGAGATTGAGACCATCGTGGCCAACATGGTGAAACCCCA TCTCTACTAAAAATACAAAAGTTAGCTGGGTGTGGTGGCGCGCGCCTCCCAGCTACTTGG GAGGCTGAGGCAGGAGAATGGCTTGAACCACGGGGGGCAGAGGTTGCAGTGAGCCAAGAT CACGCCACTGCACTCCAGCCTGGCAACAAAGCAAGATCCATCTCAAAAAAAAAAAAAAAA TAGGTGACAAATATTCCTTGAGTGCTACCATGTGCCAAGAGCCATGTTTAGTTCTGGGGT AAACACAACAAATAAGAAACCCCACTTCTCTGCTTCTTTGCTCCTCTAACTCCCTGAGGT CCCAGGGTGTGCTGGAGGGCTGGGCTTGAGCTCTGAAGAGGCAACTGTATCTATGGAAAT GCCTGGAGTGCCTGGACTTAGGGCTGTACACATGCACACATACCTATGCTGTGTCCCAAT AGTACATATGTGCACACAGACACAGGCATGCCCAGATAATCACATGAGAATGTAGGTCAT CCAGACATGTTTACCCACACACACAAGGTCACGTACATGCATTTATATTTGCATGTACAG ATGCACAGAAAGCTGCAATTGTCTGCATGCATATTTGTGTGTGCAGATGTACACACACTT ATTGGAAACCTGTACCCAAAGGATATGAACATACCCCAGATCTGTATATTGGGCACTTCC TGAAGCTCCAAGGCTCCTCTCTAACACCTTTTTCTAGATTCATTCAATAGGTGATGAATA TTCGTTGAGTAATACTATATGCCAAGAACCATGCTTAGTGCTGGGGCAAACACAACGGCC AAACAAGAACCCCCACTTCTCTGCTTCTTTGCTTTTTCTGACCACAAAGGCCAGGGACAG GTGGCATTTTTATGGCCCATGGTTTTCATGGCACTGAATTGTCTAAAAATCTAGGTGAAA AGCAAATCTATGCAACAGCTACTGGTACCTGGATCCAAGGAGGTTCTTACACTAACTTGG CTTTTTTTTTTTTTTTTTTTTTTGAGATGGAATCTGCTCTGTCACCCAGGCTGGAGTGCA GTGGTGAAATCTCAGCTCACTGTAACCTCTGCCTCCTGGGTTCAAGCGATTCTTCTGCCT CAGCCTGCCCAGTAGCTGGAACTACAGGCGTGCACCACCACGCCCGGCTAATTTTTGTAT TTTCCAGTAGAGATGGGGTTTCTCCGTGTGGCCAGGCTGGTCTTGAACTCTTGACCTCAG GAGATCTGCCTGCCTTGGCCTCCCAAAATTCTGGGGTTAAAGATGTGAGCCACCCCACCC GGCTAACCGGGCATTTGACCTGAACTAGTTCAGCCCAGTGCTGGTGAGCTCAGAGATGGA GAGTCACAGCACTCCTAAGAGGCTTGCTCTCTGTGACTATCCCCCAAGGTCTCTAAGGAT GGTTGGATAGATTGGGCACTTCACAAGAATGCCCTTTGCCCTTTTGAGGAGGTACCAAGC CTAGTGCCGGAGGAAAGATTATCTTTTTCAAATCGGTCCACCTTTTTCAGGGCAGATAAG GAGGAAGCTTCCTTTTTCTAGGAGAGCAGCCCAGAGAGGGTGTCCTCTTCTGATTGGTCA GCCTAGACGAGGCAGCTTATGTTAATTTGCACAAAAGTACAGCAGTACTAGCAGTTGCCC TGTCACTGTTTTCTTTTCAGGGCTCCTGAAAGTCTGGCTGCCTCTGCTTCTCTCGGCCAC CTTGACCCTGACTTTTCAGTGACTGACAGCGGAAAGCCCTGTGCTCCATGGCTGCCATCT CACCTCCTGCTGGGCAGGGGGCATGATGCGGGCCAGTGCTCCAGCCACAGAAAAGAAAGT TCATGCTTTGTTCAGCCTGCCTTCTTTTCTCCCTTTTAATCCTGGCTGTCGAGAAACAGC CTGTGTCTTTAAATGCTGCTTTTTCTCAAAATGGGACTTGTGACGGTGTACCTGAGGCCC CCATCTCCTTAAAGAGTGTGGCAAAATAATGATTTTTAAATCTCA OMIM ID 191845