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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for TTK (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID7272
Official gene symbolTTK
Full nameTTK protein kinase
Aliases,CT96,ESK,FLJ38280,MPS1,MPS1L1,PYT,
Gene summaryThis gene encodes a dual specificity protein kinase with the ability to phosphorylate tyrosine, serine and threonine. Associated with cell proliferation, this protein is essential for chromosome alignment at the centromere during mitosis and is required for centrosome duplication. It has been found to be a critical mitotic checkpoint protein for accurate segregation of chromosomes during mitosis. Tumorigenesis may occur when this protein fails to degrade and produces excess centrosomes resulting in aberrant mitotic spindles. Alternative splicing results in multiple transcript variants. [provided by RefSeq]
LocationChromosome: 6   Locus: 6q13-q21
Gene position80714322 - 80752244  Map Viewer
Gene orientationplus
Gene size37923 bp
Gene sequence
OMIM ID604092