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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for C4A (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 720 Official gene symbol C4A Full name complement component 4A (Rodgers blood group) Aliases ,C4,C4A2,C4A3,C4A4,C4A6,C4S,CO4,CPAMD2,MGC164979,RG, Gene summary This gene encodes the acidic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain may be cleaved to release C4 anaphylatoxin, a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus and type I diabetes mellitus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene. [provided by RefSeq] Location Chromosome: 6   Locus: 6p21.3 Gene position 31949834 - 31970457  Map Viewer Gene orientation plus Gene size 20624 bp Gene sequence >C4A:3243624..3264248:Length=20625 AGAAGGTAGCAGACAGACAGACGGATCTAACCTCTCTTGGATCCTCCAGCCATGAGGCTG CTCTGGGGGCTGATCTGGGCATCCAGCTTCTTCACCTTATCTCTGCAGAAGCCCAGGTCC TGGAGGCGGGATGCTGGGTGCTTGGATTGGGGCAGGGCTGGCATCGGGACCCGATTCAGG AGTGAGGGAGAGCAGGGGTGGAGGTGTCAGAGCGAAGTCTGACTGCTGATCCTGTCTGTT CTCCCCAGGTTGCTCTTGTTCTCTCCTTCTGTGGTTCATCTGGGGGTCCCCCTATCGGTG GGGGTGCAGCTCCAGGATGTGCCCCGAGGACAGGTAGTGAAAGGATCAGTGTTCCTGAGA AACCCATCTCGTAATAATGTCCCCTGCTCCCCAAAGGTGGACTTCACCCTTAGCTCAGAA AGAGACTTCGCACTCCTCAGTCTCCAGGTAACCAGACCCCATGCCCTCCTGCTGCTTGTG GGGGCCTCCTGCCCTGTTCCCATCTGTCTTGTAAGTGTCATCATCTTCCCACTGGCCTCC TCCCCTCCTGTCTTCCCACCCTGGCATTCTCCTTCCACGTTTCTCCCTTGGTCTCTGTCC TTTTTGGTCAGCTGTCTCTTGCTCTGTGACCCGCTCCCTCTCCCTCTCCCTCTCCTGACA GGTGCCCTTGAAAGATGCGAAGAGCTGTGGCCTCCATCAACTCCTCAGAGGCCCTGAGGT CCAGCTGGTGGCCCATTCGCCATGGCTAAAGGACTCTCTGTCCAGAACGACAAACATCCA GGGTATCAACCTGCTCTTCTCCTCTCGCCGGGGGCACCTCTTTTTGCAGACGGACCAGCC CATTTACAACCCTGGCCAGCGGGGTGAGTCTCAGCCCCAGGGCCTCAACCTTTAACCCCC TCCGAGCCCTCTCAGGATGAGTTTGGTGCCCCCTAAGTGAGATAACCTGAAAGAAAGTGC CACACAGAAGGGGTGCTTAGGAAACATTTGTCCCCTGCTCCCTCTGTGGAGTTTGACCCA CCCTCCCCTTGCACATGGACCCCTGCTCACCTCTCTCCTCCTCCACTCCCAGTTCGGTAC CGGGTCTTTGCTCTGGATCAGAAGATGCGCCCGAGCACTGACACCATCACAGTCATGGTG GAGGTGAGTCCCCGACCTCTGGCCTTCCTGATCCTGGCCACTGATGTGACCTCCTGCCTG TGAGCACTTCTCCCCTTGCAGAACTCTCACGGCCTCCGCGTGCGGAAGAAGGAGGTGTAC ATGCCCTCGTCCATCTTCCAGGATGACTTTGTGATCCCAGACATCTCAGAGTGAGCGCTC CCAATGTGGGGGCTGCCCCCAAGCTACACCACCCCAATTCCTGTTAGGCTCTCCACCTCC CACACAGAGGCACGTCCCCAGATGCCCTGACCCTCAGCCTCCTGAGCCTCTGGTTAACCC CCACAGTCCTCTTCCCAGGGAAGCAGGCTGCTGGCTCTCCGTGCCCCACTGTACAGATGG GCTGAGCCCCTTCCTTGTCCATTCTCAGGCCAGGGACCTGGAAGATCTCAGCCCGATTCT CAGATGGCCTGGAATCCAACAGCAGCACCCAGTTTGAGGTGAAGAAATATGGTGAGAGCT GGAAACTGGAGGGACAGGCAGCTGCTTTCCTGAAGGAAATAAGGGTGGAAGGAGAGGTAC TGGGAGCAGCTCAGGGCAGGGAGATATGGGTGCCACAGCCCTGAGCAGAGGGGAGTCTTT GAGCTGGAGTCTGACCTGCCTATCCCTTCACCCTGGGTCAGTCCTTCCCAACTTTGAGGT GAAGATCACCCCTGGAAAGCCCTACATCCTGACGGTGCCAGGCCATCTTGATGAAATGCA GTTAGACATCCAGGCCAGGTAATACCTCCCTCCCCACCTCTGCCCACCAGCACCGGGTCC TGCTCCCTACTCAGTATGAATGGGCTCCTGCTTCCCTGCCCTCGGGCCATTATTCCCCCC AGCCCTTGGCCCACCCTCTTCTCTCTGCCACGACAGGTACATCTATGGGAAGCCAGTGCA GGGGGTGGCATATGTGCGCTTTGGGCTCCTAGATGAGGATGGTAAGAAGACTTTCTTTCG GGGGCTGGAGAGTCAGACCAAGGTAGGAAGGAGAATAGGGGCTGGGGAGGGGAAGGGGCA AGGGAGGTGAGGTGGGAGACTCAGTCTCACCCTATGTCCTGTTTCTTTCTATGCCCCAGC TGGTGAATGGACAGAGCCACATTTCCCTCTCAAAGGCAGAGTTCCAGGACGCCCTGGAGA AGCTGAATATGGGCATTACTGACCTCCAGGGGCTGCGCCTCTACGTTGCTGCAGCCATCA TTGAGTCTCCAGGTGGGTGACTTTCCCTTATTGTAACCCCAGACCCTTGCCTCTGACCTC TGAGCTAACCCTCTGTCCTCCGGCACCAACACCACCCCACTTCTCACATCTCATCTCAGA CTCAAAACCAGGAAACACCCAGGAGACCTGGTTTCTCTCCAACTCTGTCTCTGTGACTCG GCCCTTTTCCCTGGCTGAGTTTATTTATTTCTTTGCTCGTTCTGCTCATTCCTTCACTCC TCCAGTGGACATGTGTTGTTCAATGCCCCGTGCTAGGCCTCAGCATGCACAGACATGTTG GGGACCAGCCTCAACGCCACCCGTAGGGTTCCTGAAGTCCATTGGTGACACAGGAATGAG AAGAGACAGGTTAAGAGTTCATAAAGAGTGGGGGCCAGGGGGCCAATTGCAAAATGGAGG CTGCAAAAGGCTCAGAGCTCTGGTCTCCACACTATTTTTTGAGTACAGTCACTCAGATCT AAGAAGCAGATGTTCAGGGAGAAACAGTGAAAGGGAGGCAGTGGGTCATAGGCGTAATCT ATAGCAATAGAGTTTTAAATGAATCTCCTTTGTGCTCAAACAGCATGTCTTTAAATTATC GGAGAGTAGCTGGTGGAAGTGGGCTTAGCTAGAAGACTGCATGTCTGTCCAATGCTTCAA AGGAGGGTCTTTCTCCTTGAACAGAGTGTTTACAGATAAGACAGGGGGTCTCACTCTGAG CATGGGAACATGATGGCAATTAGGAGGCTTTTCTTCTCAGAGGCCTCTTGTGGCTTTCCA CAACTTATTGTCTCATATTTTTATGGACAGTTTATACAGGCACCCCACAAGTCCTTTTCC CAACATGCCCCCCTCCCTTTTTTTTTTTTTTAACCGCTATTGCTATTATGGCTTATTTGT GGTGTTTGGTCTGTTTTCAGAAGTGTCTTTTGCATCTGTAGACTAAAAGTAAACAGCATA AACAGATACACATTAAAGTAAAATTTGTAATAGTTGATCCTTTAATGGTCTTAATCTGTT TAAGAGGATTTATGTTTGAAAGTCCGTCAGTAGCTCCAATGAGAATGTCAGTCTCAGGCA GGAGGGTTAAATGAGCCTGAGATGCTTTAAAAACCTGTTTTTTTAAAATTTGGTTATATT TAATGTTAAATTTTTATTTTTTTCTTTTAGATGATGTCTAACTTTTTAAAAATGATGTTT AGTAGTATTATACGAATGGGGAGTTATGTAGAAATTGGAAGTATTTCAATTACATTGTAC TTCTAATTGATGTTTTAAGTTTATTGTACGATCTTCCATTTAAATAACAGTCTGTCTAAG ATCATTTGTTTGATTTGTCAATTGTTGGTCTATTTGGGTCTGAGAATTCCACAATTTTGA GGAATTTTTTGTTAACTATTTATATATTTTGTAGTTTGAACAGAGGAGTGTAAAGCAATT CCAGCAGCCGCAGCAGTAGCTGTGACTGCAATAAGGCCCATAAGACTGTTATAAGGGTAA AAATAAATCTCTTTGTTTTGGTAAACACTTTTTTTTAAAACATTTTTGTGACAATATGAA TGGAAGGAGAGGCTTTCTAAGGTCTATTGAGGGAAACCAGTATCCAAACTCCTTTCTTAG TTTTTATCAGTAACACAGATGTTTTTACACCGAACGTGGAATTAATACAGGTGAAAAGGT GACAGTTTTGACAAGTAATAGTTTGAGAATTAGGTCGAATGTCAATATTTTTGACCATTA ACATAAAAGGAGGGTTGACACAACTCTGAATGGGCACTGTTTTGTTGGAAGAAAACTGAT ACGCAAATTGAAGTTTTTAACCTTTTTTTTTTAAAGATAATATATTTTTTTCTAAACTTA AATATGAGATTGGGCCATTATTAACTTTCATAATTTGGAGTGTTTAGGGCCTATTATTGG ATTAATTATTTTGGGATGTGGGCCAGCTGTACTAAAATTGGTCCAAATTATGGGAAAATG AGCACGTTTTTCAGTGTAAGTAGTGTTACCTTTTTGATAGTATAGTTTCTGTTTTAGTTT TGTCTTGTATTTATTATTTTGATGGGTACAATTAACTGTAAAGGTCCCCTCAGGGGACCA ATTAATGACAATTTCATAGGAATTATTTTGTAGTACCATAGTGTGATCAGAGATGTAATT TTTTTTAATTAATATTTTTAAATTATTTGACCATTGTTAAGGTTGTTGGCACCTCTTTTT TGGGGGCTTAAACTGTTAATTGAATTGAACTCTGTGAATGATCCGGGCTCCATCCAGAAA ATAAATGATAGGATACTGGTCTTTGATTATGACCTGGAATTTTAACTAGTCAATGTTGTC GGTAGCCTTTTAGGCAACCGATAGTTGGCCTTATGTAAAGAGGGGGGAACTGATAACCTA TGGACACATTTATTAACTTTTTTTTTTTTCCTTTGGGTGAGAGGGCCCATGAGTATTTGT AGGCTTAGGGATCCAAACGCTATTATTAACATAAACTTCAACTGGGGGTTTTAACCATGT GACAGGCCTAATTAAAGGCAGGAATGGGACACATGCCCAATAGGTATAATTTTGGGCTGT TGTAGCCACAGGTTTGTTAGGCGAGGAGGTCACTGTTTTTATTTTGGCTTTGTATTCTAG GATTAGTAAATAACAGAAGACAAACATGAGTATAATTAGTAACTTTTTTTTTTAGTAAAA GAGTGACCTGTAGTGTTACTTGGCATCTTAGTTTACTATATGTTATTAATGAGGAACCCC ACTGGGGGTATGTTAATTTATTCTAGCTAAGCAGTTATGTTATTAGAAGCTGAGAAGGGG GTGTTTGTTAAAGTAACAGGGCAGAAGAAAGGCGGATTTAAGATACGAGCTTAATACAGT GTAGCAGGTATAGGTAGTAGGCAAAGTGAGAGAATTAAAAATGAATAAATTATTTGGCTT AGACTTTTGTTTTTTTAGTATAATGTCTGAGGCCTGTGTTGTTTGTGGAAGTCGCATTGT TGAGGCTGTAGTTCCTGTAGGGTCTTTTTTAGGCTGGTTCAAATGTTTTTTTATTTTTTA ATTTTTTATCCTTTGATGAGGATGTAGTCTTTAGGCTGGTACTGGAAATTTTAGGAGTGG CGTCTGTGTTAAGAGACTTTTTACAATTTTTAAAGAGCAGGTTAGTGTTTTAAGAAAAAC TTGTGTTTTATTTTAATGTTTAGTTTATAGAAAACTGGATGATATCTTTTTAACTTTAGT AAATACGTTTACACACGGAATTTTTTACAATTATCATTTTAAAACTTGTTTAGATCTTTA AAACAAAATTAAACAACCTTTTTTGTATAAATTTTTTATAACTTTTTTTATGACTTTTAC AGACAATTTTTAACATGTCTTAACTTTTTATGTTTTATAATTTTTTTACTAAAGGTACAT TTTTATAACTTTTTAAATTTTTTTACTTTTTTGTATTTTTTTGATTTTTGTCTTAGTCTT TTTTTTACTTTTATTTTTTTAAATGTGTAATAATTAGATGAGTGTTGGTAACAATGGATG TATGTACATATTTTAGTTTTTAAAATTTAGGGATGTGTTTAACATCTGTTTGCCAGAACT GACTAGGTTCCAATTCTTTACGGTTAACACCTATTGAAGGAGGGTATGTGCCTGTGAGCT GGTAATCTGGGCATTGTGGGATAATTTGTTTAGCCAGCCTCTGTGTAAGTTGAAATTATT TAGATAAGTTTCTCCAATTTTGGTGGAATAATCGATGTGATTGGGTGGCTTGGTCAAGCA GTGATGTCATAACCTGAAGGTCTGCTTGATTATTGCCGTAAGCCAATGGGCCAGGCAGAG AGCTGTGGGCTCGAATGTGTGTAATAAAAGTAGGATGTGTACCTTGGTCTAGTAATTGTT GAAGTTGAAGAAAAAGACCACACAGAGTGGGCTCCAGAGCAAACTTAAGGCTGTAATAGT TTTTAAATAAATACACAGAATAACCTTAGCTCTCTGAATGTTAGTAAATTCAGATCAAGT GATTGGATTATGTGGTCTCCACCAGACTGTTGCTTTTTCATGTTTACCAGACCCACCAGT AAAAACAGCTATGGCTCCTTCCAAAGGGGCATCACAAGTAATTTTTGGAAGAACCTATGT AGTTAATTTTAAGAATTGAAAAGTTTTTAGGATAATGATTATTAATACATCCAACAAATT TTGTTAAATTAATCTGTCATGTAACTGAGTTAATAAATGCCTGTTTAACCTGATTTTTAT TTATTGGAACTATAATTTTTATTGGGCTCAGTGCCACAAAGTTTAATAATTCATATATGA GCCTGTCCAATTAGAATTGCCATCTGATTTAAGTATACTGTAAGTGCTTTTATGGTATTA TGTGGCAAAAAGGACCATTTAACTAAATCATCATTTTGAACAATAACCCCCATTATTGTG TGGTTAGTGTGAAGTAGGGAACACAATGAATTATAAAGGCAAGTCTGAGTCAATCCTACT GACCTGGGCTTGCTGAATTTTGTTTTCAATTACTGATAACTCTTTCATGGCCTCGGGTGT TAGTTCTCTGTTACTGCGTAAGTTGGTATTTCCCCTCAATATTGAGAAGAGATTAGACAT AGCATAAGTAGGAATTGCTAAATTGGGCCAAATCCAATTAATATCTTCTAACAATTTTTG AAAATTATTTAAGGTTTTGAAAGAATCTCTTCTAATTTGAACCTTTTGAGGCTTAATGGC TCTATCCTGTACTTGTATTTTCAAATACTGAAAAGGAGTGGTTGTTTGAATTTTGTCAGG TGCTATAAGTAATTCAGCATTTGTAATTGTCTTTTGCAAAGATTAATAATATTGAATAAG TTGGTCTCTACTTTTTGCTGCACAAATCTGGAAACTGATCTCTAACAGGCTGGATAGTTC TGCCTACAAAAGTTTGACAAACTGTGGGACTATTTAACATACCCTGGGGCAAAACTTTCC AATGATATTTGGCTGCAGGTTTTTTGTTATTAACGGCAGGAATGGTAAAGGCAAATTTTT TGAAATCTGCCTCTGCTAAAGGAATTGTAAAAAAGCAGTCTTTTAAATCTATAATAACAA GCGGTCAGTCTTTAGGGAGCACAGTGGGGGATGGGAGCCCAGGTTGTAAGGCTCCCATCG GTTGAATTACAGCGTTGACGCCATCTACCGGACTTTTTCTTAATTACAAATACTGGGGAA TTCCAAGGAGAGAAAGTGGGTGAAATATATCCTTTTTTTAGTAGTTTATTTTATAAAGCA CCCCCAACTTTTCCTTAGGGAGCGGCCACTGTTCAACCCAGACGGGGCGCCGGGTCATCC ATTTTAAGGGAAATTGCTCCTTCACTGTAATAACTGTAGGGTGAACCTGAATTGCCCCAT CTCCATAATGAACTGTGGGTCGGGCAATAATGGGCACGGTGAGCCAAGTCTCGGGCTCCC TCCCCCTGCACCCACTCGGCTGAGGAGGAGGTGGCCATTCTGGACATTTCTCTACAGGAA CCGTGGGCTGAACAATTTTTTGAGTAGGTTTAGGGAGACTGGGGAGATTGGCATAAATCA TCTTCAGACTCTCCTTTTTGTTAGTACTCGGTAGAGGTGGTTCAGAGTTCTGATTATCAA ACTCCTCTCTCTCCTCCTCTGACTCAGCCTCATTATCTGTCTGAAAAGGCTCCAGTGCTG CATGCACCAATGACCAAAGCGACCAAACAGGCAAAGGAATTTCCTTTCCTTCTCTATATG CTCTTTTAAGGTCCTTTCCAACTCCTTCTTAATGTTTTAATTTCAAAGTTTCCTGTTTTG GGAACCAAGGGCAAAATTGTTCCATAGCATGAAACAAATCCATAAGATTTTCCGTATCAA CTTTTACCCCACCATGCATGCTTGAAGAGCTGCCGTAGGAAGCTCAAATACGTGGTGTAC TTACTTTCAGTTTTTCCCATTGTGTCCCTAGCTTTCTCTGGGCGCCCCGCTTACCTGTAG AGGTTAAAACTTTTATGTCCTTGGGAGTCCTTTGTTCGTTGGTCCTCTGTTTCACATGCT TGAGCGTTTCCTCACCAGATTCTTTTGGGCCCCACGTTGGGCGCCAGAATGTTGGGGACC AGCCTCAACACCACCTGTAGGGTACCTGAAGTCTGGTGGTGACAAAGGAATGAGAAGAGA CAGGTTAAGAGTTCATAAAGAGTGGAGGCCAGGGGGCCAATTGCAAAATGGAGGCTGCAA AAGGCTCAGAGCTCTGGTCTCCACACTATTTATTGAGTACAATAACTTAGATCTAAGAAG CAGATGTTCAGGGCAAAACAGTGAAAGGGTAGCAGTGCGTCACAGGCATAATCTACAGCA GAAGCGCTTTAAATGAATCTCCTTTGTGCTCAAACAGCATATCTTTAACTTATCGGAGAG TAGCTAGTGGGAGTGGGCTTAACTAGGAGCCTGCACGTCTGTCCACATTCCAATGCTTCA AAGGAGGGTCTTTCTCCTTGAATACAGTGTTTACAGATAAGAGAGAGCAGGTCTCGCTCT GAGCATGGCAATTAGGAGGCTTTTCTCCTCAGAGGCCTCTTGTGGCTTTCCACAACTTAT TGTCCCATATTTTTATGGCCAGTTTATACAGGCACCCCACAAGTCCTTTTCCCAACACAG ACAGGAATACGGCAGCCTGTGCCCTGGGAGCTCACTGTCTTGTGGGAGGGAACCACTCAA GCCACTCCCCACTTGTCCTCCTGTCCCTCTCTTCTTGGGCTCTGTCCCCCACCTCTCTCT GTCCTTTGTCTTGCAGGTGGGGAGATGGAGGAGGCAGAGCTCACATCCTGGTATTTTGTG TCATCTCCCTTCTCCTTGGATCTTAGCAAGACCAAGCGACACCTTGTGCCTGGGGCCCCC TTCCTGCTGCAGGTTTCTTCCAGAGGGGAAGGATGAGTAGGGAGGATGTGGTAGTTAGGA GGGCTCAGGGTCTGACCACTCTCTTTTGCCTGCCCTCCTTTACCTGCCTAGGCCTTGGTC CGTGAGATGTCAGGCTCCCCAGCTTCTGGCATTCCTGTCAAAGTTTCTGCCACGGTGTCT TCTCCTGGGTCTGTTCCTGAAGTCCAGGACATTCAGCAAAACACAGACGGGAGCGGCCAA GTCAGCATTCCAATAATTATCCCTCAGACCATCTCAGAGCTGCAGCTCTCAGTAGGACTC CTCGGACCCCTGGGAGATGGTGGGGGAAGGGGAGGAGGGTGAGCTGGGGTCCCAAGGATC CATGGCCTGACTTGGGGGGAAGGTGGGGTACTTGGCTCTGAGCTACTACCCTATTCGCAC CTGACCCCCTCTCCAGGTATCTGCAGGCTCCCCACATCCAGCGATAGCCAGGCTCACTGT GGCAGCCCCACCTTCAGGAGGCCCCGGGTTTCTGTCTATTGAGCGGCCGGATTCTCGACC TCCTCGTGTTGGGGACACTCTGAACCTGAACTTGCGAGCCGTGGGCAGTGGGGCCACCTT TTCTCATTACTACTACATGGTGTGCATGAGCTGGGGAGTCACGGAGGGCTGGGGTGCAGG GAAGAGCCCTCTGGGTGGGGCTGGGGGGGTTCAAGGCTGAGGCTGTCCCATGAAGAGGCA ACCACTCTTGTCCCTCCCATTCTTGGCCCAGATCCTATCCCGAGGGCAGATCGTGTTCAT GAATCGAGAGCCCAAGAGGACCCTGACCTCGGTCTCGGTGTTTGTGGACCATCACCTGGC ACCCTCCTTCTACTTTGTGGCCTTCTACTACCATGGAGACCACCCAGTGGCCAACTCCCT GCGAGTGGATGTCCAGGCTGGGGCCTGCGAGGGCAAGGTGACCGGGGTCAGGAGAGATGG CACTTGTGCCGAGGGGGTTGAGGACAGGGTGATTGCCAACAGGGCATGGATTTAGCTTGG GGGCAGTGAGGATACCGGGACTGAAGGAAGCTCTCCCACTCTGACCGCCCCCACCTGCCG CCCCTGCCAGCTGGAGCTCAGCGTGGACGGTGCCAAGCAGTACCGGAACGGGGAGTCCGT GAAGCTCCACTTAGAAACCGACTCCCTAGCCCTGGTGGCGCTGGGAGCCTTGGACACAGC TCTGTATGCTGCAGGCAGCAAGTCCCACAAGCCCCTCAACATGGGCAAGGTTTGTCCAGA CCCTCTCCACAGCTCTCTCACCCCTCCATGGCTCATCCCCCTGCTTCCCTGAGCCTTGGG CGCAGCCCCTGGATCCCACTGAGGCTCCCCACAGTCTCTTCCCCACTTGGCCCTGTGGTC TCCATCTCCTGGCTCTGTATCCTTTCCTATCCCCCCATGTGCTGCCCTCTCACCTGTGCC GAGTGCTCAGTCCTGCCCCTCAGCCACACTTGGCTCCTAGCATTCCTGCCTTTCTTGCAG GTCTTTGAAGCTATGAACAGCTATGACCTCGGCTGTGGTCCTGGGGGTGGGGACAGTGCC CTTCAGGTGTTCCAGGCAGCGGGCCTGGCCTTTTCTGATGGAGACCAGTGGACCTTATCC AGAAAGAGTGAGAACAGAGAAGGAAGGGGAGTGGGTGGCGGGAAGATAAGGAAGGAGGAA GGGCCTGAGGGGACCAGCTGGAAGAGTCCGGGCAGGAAGGGCTGGGCAGGGGAAGGGGAG GAGGGGAGGAGGCCGAGTGCCTGACGGCTGGACTGCAGCCTTTCTCTCTACCAGGACTAA GCTGTCCCAAGGAGAAGACAACCCGGAAAAAGAGAAACGTGAACTTCCAAAAGGCGATTA ATGAGAAATGTGAGTTGCGGGTGCCTAGGCAGTAGCTTGGGCTCTCCACCTGGGATCCGG GTTGGGGGTCTGCCTCTCTGCCCCTCGGCTCCTTGCTGAACCCACGTGTGGTATTTGGGG CCAGAGATCCGAATTCCGGGATTACGAGTGGAAGGTGGGCAGCTCTCTCCAGCAGCCTCT CTTATGTTGCTGGTCTCAAGGGGTCGGGGCGGGGGCTGAGGTGTATGTCCTTTTTGTCCT CTCATGCTCACCCCCACCTGGCCCTGCAGTGGGTCAGTATGCTTCCCCGACAGCCAAGCG CTGCTGCCAGGATGGGGTGACACGTCTGCCCATGATGCGTTCCTGCGAGCAGCGGGCAGC CCGCGTGCAGCAGCCGGACTGCCGGGAGCCCTTCCTGTCCTGCTGCCAATTTGCTGAGAG TCTGCGCAAGAAGAGCAGGGACAAGGGCCAGGCGGGCCTCCAACGAGGTGAGGGGCTGGG TGGGGCTAGGGCACAGGTGGCGGCGCTTGGAAAGGCAGAACGGTCCCCTCCTCACTCCCG TCCACCGTGGTCCCCCAGCCCTGGAGATCCTGCAGGAGGAGGACCTGATTGATGAGGATG ACATTCCCGTGCGCAGCTTCTTCCCAGAGAACTGGCTCTGGAGAGTGGAAACAGTGGACC GCTTTCAAATGTGAGAGTGTGTGCCGGCCCGGCCTTTTCTCTGTGCTGTGTCTCGGGGCC AGCCGGGGTAGACGGGCCTTCTCTGCCTTTCCCTACACAGATTGACACTGTGGCTCCCCG ACTCTCTGACCACGTGGGAGATCCATGGCCTGAGCCTGTCCAAAACCAAAGGTGATGTCA CCCTGTCTGGGCCTCAGGTGACCCTGCTTCCATTTCCCTGTACCCCAGCTCCCTGTTCCC TTTGCTCTTAGTGTAGGAAGAGGGTCCAGTGATCTGGGGAGGTCTGTGCCAGCGTGCAGC TGGCGTGGGCCAGAGGGCAGAGGCGGACTGAGACAGAGCTGGGTCACCCCCACCCCTCCC TCCTGTGGCCCTGAAGCTTTGATGGCCCCTCTGATCTCTGCCCCTGTGCCCACGCTTCCT TTCCCTCAGGCCTATGTGTGGCCACCCCAGTCCAGCTCCGGGTGTTCCGCGAGTTCCACC TGCACCTCCGCCTGCCCATGTCTGTCCGCCGCTTTGAGCAGCTGGAGCTGCGGCCTGTCC TCTATAACTACCTGGATAAAAACCTGACTGTGAGGCCCCATGGGAGCCTGAGCATACAGG AGTTGGGGGAGCCAGGGCCCAGTGAGGGGTGGGGAGGCTAACCGGGCCAGGACTCTGGCC ATCCTCGTTTTCCTGCCCTCAGGTGAGCGTCCACGTGTCCCCAGTGGAGGGGCTGTGCCT GGCTGGGGGCGGAGGGCTGGCCCAGCAGGTGCTGGTGCCTGCGGGCTCTGCCCGGCCTGT TGCCTTCTCTGTGGTGCCCACGGCAGCCGCCGCTGTGTCTCTGAAGGTGGTGGCTCGAGG GTCCTTCGAATTCCCTGTGGGAGATGCGGTGTCCAAGGTTCTGCAGATTGAGGTGAATGG AGCACCCCTGAATATAAGTCCCCGGGCCCCCAGCTTTGTCCTCCACCCTCAGCACTCTCT CTGCTGGCCAGGCCAGGGGCCCAACACCCGAACCAATGCCTTGGTCTGTTCCCATCTTCT ACAATTCTGATCCAACTCTGTCCCTGGAGTTGAAACTCAAAGTTCTGGGGGAGTCTGCGC TAGCAGGGCAGGCTGTAGTCCTGTGTGACCTCACAACCATGTTTTCCCTGAGACAGAAGG AAGGGGCCATCCATAGAGAGGAGCTGGTCTATGAACTCAACCCCTTGGGTGAGTGACCCT CTACCTCCAGCCATTGGTTTCCTAAGTGGGTACAGGTGGTGGGGGATGTGGACAGCAGGA CAGGCTGCCAACTTCCCCCATTTCCCCAGACCACCGAGGCCGGACCTTGGAAATACCTGG CAACTCTGATCCCAATATGATCCCTGATGGGGACTTTAACAGCTACGTCAGGGTTACAGG TGGGAGTGCCCTTTAGTCCCTTCCCAGTGGCCACCTTCGGATTCATGTGGGACCTGTGGA TCCCTGCTTGGTCCCACTCCCCGTGAGCCTCTGACACAGAGTCCTCAGACCTCCACCCTC TCCCTCCCATGTAGCCTCAGATCCATTGGACACTTTAGGCTCTGAGGGGGCCTTGTCACC AGGAGGCGTGGCCTCCCTCTTGAGGCTTCCTCGAGGCTGTGGGGAGCAAACCATGATCTA CTTGGCTCCGACACTGGCTGCTTCCCGCTACCTGGACAAGACAGAGCAGTGGAGCACACT GCCTCCCGAGACCAAGGACCACGCCGTGGATCTGATCCAGAAAGGTTCTGGGTGCAAGGG CAAGCAGGAGGGGGGCCAGGAAAGGACAGTTACTGGAAGATGGACAGCCCAGGAGGCTAC AGAGGGAAAGAAAGGGGGCCCCTGATGAGGATGGGGAGCATGGCCTTGGGCTCAAACAGC AGAAGGGTGAGTGTCACCTGAGCGGCCACCTCTCCTCTCCAAGGCTACATGCGGATCCAG CAGTTTCGGAAGGCGGATGGTTCCTATGCGGCTTGGTTGTCACGGGACAGCAGCACCTGG TGAGCTTGGGAGAGTGGTTCCAGGGTTCTGAGGGGGTCAGGGCTGGGGCAGGGGTGGGAC AGAGCTGGTATGATGGGAGGGTGGATAACCAGGCACCTGGGGGCGTGGGCATAATGAGAA GCAAGTCCTTATCCCCAACCCTCCTTTCCTGCCCTCCAGGCTCACAGCCTTTGTGTTGAA GGTCCTGAGTTTGGCCCAGGAGCAGGTAGGAGGCTCGCCTGAGAAACTGCAGGAGACATC TAACTGGCTTCTGTCCCAGCAGCAGGCTGACGGCTCGTTCCAGGACCCCTGTCCAGTGTT AGACAGGAGCATGCAGGTGCGGGCATGCTGGGGCTGGCCCGAGAAGCGCCTGTCGGAGGA CTCTCTTTGCCCCTTCCCCCTCCTGTTTGACATCTTTTCTCCCCTTACTAGGGGGGTTTG GTGGGCAATGATGAGACTGTGGCACTCACAGCCTTTGTGACCATCGCCCTTCATCATGGG CTGGCCGTCTTCCAGGATGAGGGTGCAGAGCCATTGAAGCAGAGAGTGGTAAGTTCAGTG GCGTTTCTGCCCTCTGCTGGCCCCCAGCTCTCTCCCTTTTTCCTCAGGAACCCAGGGGTC CAGGCCCAAGACCCTCCTCCCGTTTTCTTCCAGGAAGCCTCCATCTCAAAGGCAAGCTCA TTTTTGGGGGAGAAAGCAAGTGCTGGGCTCCTGGGTGCCCACGCAGCTGCCATCACGGCC TATGCCCTGACACTGACCAAGGCGCCTGTGGACCTGCTCGGTGTTGCCCACAACAACCTC ATGGCAATGGCCCAGGAGACTGGAGGTGAGGGGTGAGGCGCTCCTGGCAGTGAGCCTGAG GCCCAGGGGACCTTAGGATCCCTGAGTGTGCCCAGAGGGAGAGGCTGGATGAAGACTCAG AGGAGGAATGAAGTTATAAGCAGGGGTGGGTTGGGGGAGACTCAGGAGAGCCCAGCAGGG GGTGGCTAAGGGCCAGGGGACCAGGCTCTTCTCCCTGCCTTCCTGTTTACTTGTGGTCTC CCTTCACTTTCAGATAACCTGTACTGGGGCTCAGTCACTGGTTCTCAGAGCAATGCCGTG TCGCCCACCCCGGCTCCTCGCAACCCATCCGACCCCATGCCCCAGGCCCCAGCCCTGTGG ATTGAAACCACAGCCTACGCCCTGCTGCACCTCCTGCTTCACGAGGGCAAAGCAGAGATG GCAGACCAGGCTGCGGCCTGGCTCACCCGTCAGGGCAGCTTCCAAGGGGGATTCCGCAGT ACCCAAGTAGGGGCCGTCCCCGGGCTCTGGGGGGGGTGGGTAGTCCTCAGACCAAGGGCT TGCTTGAGTCCTGGCTCAACCTCCCTAGGACACGGTGATTGCCCTGGATGCCCTGTCTGC CTACTGGATTGCCTCCCACACCACTGAGGAGAGGGGTCTCAATGTGACTCTCAGCTCCAC AGGCCGGAATGGGTTCAAGTCCCACGCGCTGCAGCTGAACAACCGCCAGATTCGCGGCCT GGAGGAGGAGCTGCAGGTGAACCACTCCCTGGTGAACCACTCCCTCGCCTGGGTAGCCAG GACACCTGGGCCTCGTGGCCAGGCCAGAAGCCGTCCCCACCCTCCCACCCGTGGAATCCC CGCAGCACTTCTTCCTGGGGTCTTCGGGGGAAGACTGACTTCCTGGCTGCGTGACCTGGA GCTCTGAGCTTCAGTTTTCTCACTTGTAGAGTAACATACACAGAGTTCACCCTACAGGGT CGTTAGAAGGCTGAAGTGAGATAATTCATGTGCTGGTATAAACTTTGTGGAAATGTGAGG TGGGGAGAGGAGGTGGGGCTGTTTTGAGGAAGGAGATAAGTTATTGGAGCCGCAAAAACA GGTTTGCTTGTGCCCTTCTAACATCGCCTTCCCTTTTCTGTTGCTGAAGTTTTCCTTGGG CAGCAAGATCAATGTGAAGGTGGGAGGAAACAGCAAAGGAACCCTGAAGGTGAGGGCCAG GGAAGGGGTGGGGCCAGGCACTGGTGGAGGAGAGGGTGTGGAGTGAGAGGCCTGTGGGCA GAGGCACATGGTCCGGGGAAGGAGGCAGACACCTCAGGGTTGGTGTCCCGTGCTTCCGTC CTGGGTGTTTTTCCCCCTGCTTGCTTTCGCTTGCTCTCCCCATCTCTGGGTACCTGTTGT TTCCTTTACCCGCCTCAGTGCTGGTGGCTCCGAATCCCACTCCTCAGCCCAGGCCTCTTC CCTGAACCATGGGCCCCACTCGTCCCACTCCCACAGCACCTCAGACGAGGCATGTCCCAA AGCCCTTCTTCATTCTGTGTCTCTTGTCTGGCTGGTGGGAGCCCCTCCCAGCCAGGAGCC CAGCCACTACTCTAGAGGCCGTGTTAGTGGCCCCTCTCCCAAGCCTGTCCTTATGTCCCT AGTGACTCCTCCTCTGCTCCCCTGCTGCCTGTGGCCCTTGGTGCTGCATCCTAGATTCTG TGCTGAGACGGCCTTCTCCCTACCTGGAACTTCTCTCTACCTCCTGTCTCCCCTGTCTGA TCCACTGTCCACACGGCAGTGACACTGACCTTCCAAAAGCCCCAGCCAGATCAGCCTTGG GGAAAAGTCACTCCCCGCTGCCCACGGCTCAGATGGCTGGGCCTCTGCCCACCCCTCCGG CCAGACAGCTCTCCTTGTCTACACAGATCCCCTTGCCTTTCCTGTCCTTCCCTGCTTCTT GGCCCACAGGACAAGCTCTTTCTTCTCCTTCAAGCCTTGGCCAGAAGCCTTTCCTGAGCT TTTCAGTCCAGCCTCTTCCCAGCACAGTCTGGAGTGTTGGCCTCTGGGGGCAGGCCCCTG CTTCTTTACCTCTCTGTCTCGCCTGACGCCTGTGGCGAATGTGGTGCCACTCGTGTGTGT GGACTGTGCAGTGACGGGGAGGAAAAGGGGCTGAAGGCCTCAAATCCTGTAGCCCAGGGA GATGCCCTTAGGTATGGCACCAGAGAGGTCTGTGGCCTCACATGTCCCACGTCCTCTCCC TGCCCCTTGCTGAGCCAGGTCCTTCGTACCTACAATGTCCTGGACATGAAGAACACGACC TGCCAGGACCTACAGATAGAAGTGACAGTCAAAGGCCACGTCGAGTACACGAGTGAGTGT GGGGGTTGGGAGGCCTTGGGGCCAGGCAGGGGCTGGCGCAGGGAGCCGGGTGGCCATCCC AGCCCTCCTCACAATGCTTCCCTGTGCAGTGGAAGCAAACGAGGACTATGAGGACTATGA GTACGATGAGCTTCCAGCCAAGGATGACCCAGATGCCCCTCTGCAGCCCGTGACACCCCT GCAGCTGTTTGAGGGTCGGAGGAACCGCCGCAGGAGGGAGGCGCCCAAGGTGGTGGAGGA GCAGGAGTCCAGGGTGCACTACACCGTGTGCATCTGGTGGGCGCCGGGAGCTGCCCTGGG CCAGGGGAGGGAGGGCAGGACCCAGGCTGGGGCTGGGCTTCTGGAGCCCGCGCAGGCAGA ACCTGGACGACAGCTCACACGTCTCCACAGGCGGAACGGCAAGGTGGGGCTGTCTGGCAT GGCCATCGCGGACGTCACCCTCCTGAGTGGATTCCACGCCCTGCGTGCTGACCTGGAGAA GGTGTGGTCAGCCACCCAGGGCAACCCCCTCTGTCCCAGGTACTGAGCCCTGTCATGTGC AGGGCCTGTGACCAACTCCCCTTTTCCACAGCTGACCTCCCTCTCTGACCGTTACGTGAG TCACTTTGAGACCGAGGGGCCCCACGTCCTGCTGTATTTTGACTCGGTGAGTGGGGAGAG ATGAGGCAGGAAGGGACTCGATGGCACCGGGTTTACTGAGTATGCGTTAGGAGGTTTCTC AGGAGACAGCTGTGTCAGCGGCTGGTGCTCTTGAGAACTTGTGATGTCATCAGAGAGAAG GACAAGAATGTGAGCCCGTGAGACACAGCAGAGTAAGGGGCAGACCTGCAGGCGGCAGGG ACCGATGCCAGTCAGCAGGGACCCTCAGGGTTTGAGAGGGAGTCTTTCCTAATGCTGGTT TTATTCAGCTTGAGGGGCTGCCTTTGTTTTTTTGTTGAACTTCCTATCTTTTTTTTAATA TTAAAGCGTATTTTCCTTTACAAAGTGATGGTGGCCATAGATGATAGTTGTATTTGTCTT TTCACGACCTTATTTGGCTAAAATAGTTATCAACCCTCTTACGGCTCTCAAAACATTTTT ATTTATTTATTTAGTAAAGACAGGGTCTCGCTCTGTTGCCCAGGCTGGTCTTGAACTCCC GGCCTCAAGCGATCCTCTGGCCTAGGCCTTTCAAAGTACCGGATTTACAGGCCAGAGCCA CCATGCCCGGCCTTCAAAAAAAGTTTTGGAACATTTACTGTAACCTCTGGGAGAAAATGT GAGAAAGGTGTGGTGGCTGTCATTAGCCAGCTGTTTGTAGGTCAGGGAGACCCCTACCCA GTGTGTGCAGAGGGGCCAGCCCCCATCAGCTGGGGAAGCCTGGCTGACACATCTGGGTTG AACACAATAGAAAACACAGAGCCAACAAGATTCCCGGATAGGGAGCTGACGGTGCAGCAG CCTAGCTCAGGAGGGACACTGGCACGGCACCGTGTGGACTGGGCCCGCGTGGGCACGAGG AGGGGTCAGGCCTGGGACCTGAGTCGGGGGGTCAGGCAGGATGACAGAACCTGCAGTTAG GTTGTGGCAAATAAAGGAGGACCCAGTTGTATCCATGACAAAGATGAGGCCGCGAGGAGG GCGAGTGGGTTTGGGGGCAGGCAGAGTGCCTTGGAGAACTTACAGGTCCTGCCACAATCC TAATGCAAGGATGGAGCTGCAAGTTCAGTTTGGGAATCATCAGCCTGGATTGGTTTGGTG GAAGCCAGGGAGTGGTTGAGACCCCCACAGGGGAGCTCTGAGGAAGGAAGTTCCGAAGGA GGGAACGTAAGAAATGACCAGGTCAGAACCAAGGGTGGTCCAGAAGCTAACCCTTAGCTT AGGGACAGTTTCACAGAGAACACGTCCATGATGCAAGACTCTGCTGAGGGCCTGGAGCAG TGAAGACTGGGGCAAGGTCACCCTCTGGGAAGTGAAGTCACCAGAGACCTTGCGGAGCAG CTTTGAGAGTTCTCTGAGTAGGAAGGTAACAGAATGTGAAGGACACTGGAGAGAAGGCCA ATAGGAAGCAAACAAAAACAGGCCAAGGAAACCCAGTACAGGGGGCTGCAGGGCCCAGGG AGTGGGTCCCTCATCTCTCCTCCCCACGCTTGGCCAGGTCCCCACCTCCCGGGAGTGCGT GGGCTTTGAGGCTGTGCAGGAAGTGCCGGTGGGGCTGGTGCAGCCGGCCAGCGCAACCCT GTACGACTACTACAACCCCGGTGAGCACTGCAGGACACCCTGAAATTCAGGAGAACTTTG GCATAGGTGCCCTCCTATGGGACAATGGACACCGGGGTAGTGAGGGGGCAGAGAGCCCTG GGGCTCCCTGGGACTGAGGAGGCAGAATGGAGGGGCCTGTGCCCTAACTCCTCTCTGTTC TCCAGAGCGCAGATGTTCTGTGTTTTACGGGGCACCAAGTAAGAGCAGACTCTTGGCCAC CTTGTGTTCTGCTGAAGTCTGCCAGTGTGCTGAGGGTGAGACTGAGGGCCTGGGGCGGGG CAGTGGAGGCGGGATGGCCGGGGCCCCCCCCACACTGTCTGATGGGTTCCCCAACTTCAG GGAAGTGCCCTCGCCAGCGTCGCGCCCTGGAGCGGGGTCTGCAGGACGAGGATGGCTACA GGATGAAGTTTGCCTGCTACTACCCCCGTGTGGAGTACGGTCAGTCTTCCCACCGAGGCC CTGGCCTGACCCTCCCTCGGGGACCGGCTGTTTTGGTCTCTCTGGGTGTAGCCTGCTCCT CTTACAGGTCATGCACGCAGCCTGTTTGCTCTGACACCAACTTCCTACCCTCTCAGCCTC AAAGTAACTCACCTTTCCCCCTTCTCCTCACCCCCTCTTAGGCTTCCAGGTTAAGGTTCT CCGAGAAGACAGCAGAGCTGCTTTCCGCCTCTTTGAGACCAAGATCACCCAAGTCCTGCA CTTCAGTATGAAGCAAACCGGAGAGGCGGGCAGGGCTGGGGGGAGACAGGGAGGCTGAGG TGTGGCCGAGGACCTGACCATCTGGAAGTGTGAAAATCCCCTTGGGCTGTCAGAAGCCTT GGGCTTGGCCATAAATAGGGAGGCAGTGGCACCTCTCCATGGGGGTGGCGAAGGTGGAAT GAGAGGATCTACACAGAGTCCCCAGCCTGGGCTCACCCTGCACCTTCTCTTCCCCTCTGA CCACTTTTGCGCACGTCATCCCCGCAGCCAAGGATGTCAAGGCCGCTGCTAATCAGATGC GCAACTTCCTGGTTCGAGCCTCCTGCCGCCTTCGCTTGGAACCTGGGAAAGAATATTTGA TCATGGGTCTGGATGGGGCCACCTATGACCTCGAGGGACAGTGAGTCATCTGGTCCCCTC AGTCTCTTGTCCTCCCCATGCCTCGCCACCTAGGCCTTGCCCCTCAGAAGCCAGATGCCT GTGCTCTCCGTTTCCACCTGCCATCCTCCCGAGCCCTGCTGACTGCCCCTTTGCCCCCTG CAGCCCCCAGTACCTGCTGGACTCGAATAGCTGGATCGAGGAGATGCCCTCTGAACGCCT GTGCCGGAGCACCCGCCAGCGGGCAGCCTGTGCCCAGCTCAACGACTTCCTCCAGGAGTA TGGCACTCAGGGGTGCCAGGTGTGAGGGCTGCCCTCCCACCTCCGCTGGGAGGAACCTGA ACCTGGGAACCATGAAGCTGGAAGCACTGCTGTGTCCGCTTTCATGAACACAGCCTGGGA CCAGGGCATATTAAAGGCTTTTGGCAGCAAAGTGTCAGTGTTGGC OMIM ID 120810