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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for TNNI1 (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 7135 Official gene symbol TNNI1 Full name troponin I type 1 (skeletal, slow) Aliases ,DKFZp451O223,SSTNI,TNN1, Gene summary Troponin proteins associate with tropomyosin and regulate the calcium sensitivity of the myofibril contractile apparatus of striated muscles. Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. The TnI-fast and TnI-slow genes are expressed in fast-twitch and slow-twitch skeletal muscle fibers, respectively, while the TnI-cardiac gene is expressed exclusively in cardiac muscle tissue. This gene encodes the Troponin-I-skeletal-slow-twitch protein. This gene is expressed in cardiac and skeletal muscle during early development but is restricted to slow-twitch skeletal muscle fibers in adults. The encoded protein prevents muscle contraction by inhibiting calcium-mediated conformational changes in actin-myosin complexes. [provided by RefSeq] Location Chromosome: 1   Locus: 1q31.3 Gene position 201390874 - 201372895  Map Viewer Gene orientation minus Gene size 17980 bp Gene sequence >TNNI1:complement(52861537..52879516):Length=17980 CTCGGCTCTGCCCCTCACAGTCTGCAGTCTACGGCGAGGCACAGGCCAGCCCAGCTCCAC GAGGACTGAACAAGGTAAGCGTCTGCAGCCCAGAACTTCAGATGTAGGTTGATCCCAGGC AGAGAACCTGGGGCTTTTGTTTAAGGAGAAAGCGAGGTCTTGGAGCTGGAGAAAACCATT TCTTGCCTGTGCAGTTGGTTTGTTGGTAGAACATTCCTAAAATACTCCCACAGCATTTTG TCCCACAGAATGGCATCTCTCCTGCAAAACTGTTGTGAGAGGTGAAACTTTTTCCTGGCC ATTTGGAGGCTGTGAGCAAGGAGCAGAATCTTCCGTGAGGTTCCTTAGGAGCCCCAGGGC AGAGCCTAAGGGATGATGTTTTCACACAGGATGCCCAGCAGAGTGTGGGAGGGAGAGCGC ACCCAGGGGAAGGGGTGGCCCTGGGATCAGAGAGCCAGGGTGAGTGCTCAAAGTCAGCAA TGCCTGCAGCGGAAGAGAAGGAGGGTGCCTGACGCGCAGGACTCCCAGGGAGCCTAGAAG GCAGGGCCAGAGCTCCCTGCTGGCCAAGGAAACCATCTTGCTTCTGTGTTCTTTGTCTCT GAGCGACGCTGTTAGCTCCCTTTGCCTATCCCTCTGTAGTGTAGCACAAGAGCAGAGGAG GGCAGACCGGCAACCCCTCTTGACTGCTCCTGCTCAGAGCTCCTGGCTCTGAGAAGCAGC AGTAGATACTGGGGGTCCTCTTGGAGGAAGGCAATGGTGGCGGCATTTTGGGTTGGGGCA CAGGAGCCAGTGAACACATAAGCCAGGGCAGTATCTACAGGGTAACCCAAGGCTTGGGGC AGGGGGCCGTGTGGCGGTCCCTGACTCAGGTGGGGGCTGAAGGCAGCACCTGCCACCAGG TTTGGGAGTCACAGTCCCACAGCAGCTCTGAGATTAGGCTTTGCTGTTCAGAACTCAAGA TGGGGGCAGCCCAGCGCCATGCACTTGGGAGTGTTAACCGTCAGTCAAGGAAGACAGGGA TGCCCTTGAATGGGGGTCCAAGGTCAGGGGGCGGGGAGCAGGGGGAAGCACATGAGCCTA ACTAGATACTTGTGGACGTGATCATTGGGTGTGCAAAGAGATCAGTTCTTTCCCCTACAT ATACACGCTCTCTCTCTCACACTCACACTCTCACACACAGTCACTTACACACACTTACAC ACACAGACTCAATCTCATAGTCTAGCGGATAGTCCCTTCCACGCTGCAAAGCCTCAAGGA AGGGAAAGCCCAGCTCTGAGGCAACCACCAGAGACTCTTTGCTCCCCCCCTCGGGGGGAG GATTTTCTCATTATCTCCTTGCTTGCTACTTGTAGAGGAGATGGAATCCTGGCTCTCCAA GCCTTCCAGTGGCTGCTATCTTCATCCTGACTTATCAGTCCTCGCTTGTCTTCCACAGAG CCTGGCAAGGGCCCCCGTCTGAGGGGTGTCAGAGCACAGGCTGAGGCCTCTTGCCTGACG TGGGACCCCTTGGTCTGGCATTTGTCAGTGAGGCAGGCTGGGGGCAGGCCCCGGAGCTTG GCAGGAGGTGTAAACCGGCCTTGGAAGGTAGGGCCCCACAATGGGGACAGTTGGATCTCT GAGGGAGACAGGGAGGCATGATCACTGCCAAATGCCCACCAAGGACAAGGCACATCCCAG GGAGACAGACGCAGACCTGGTGCCCTCTGGACACTGGCATTCCTGGAGGCTGATGATGGA CAGATGGGCCTGGAGGTGGCTCTTCGCCAGCTGGTGTTTCCTTTGGACTTCCTCAGTGTC TTTGGAGAAGCAGAGCCCTAAGAATAAGCAGCTGCCCATAAAATCTAATACCAGCCAAGC ATCTCAGGAATTCATGGATTGTCTCCATACCCCTCCCTCTGTGCCCCAGCATGACAGCTG AGACTCTGGGGTCACACTACACCTCCACCTCCTCCACCCCAGCCTTACCCTCCCCTGGTG GCGGAGGCAGAGGTGGAGGGAGGCCCAGAAGGCTTTCTGACCCGTTGGGAGATTCAGGGG AGGTGGCCAAAGCTGTGTTCATTGGGGTTGGGATAGTGCTTCATGGGCACAAAGGGAAAG GAGAGAATTAGGGCAGAGGAAGGGGTGGCTCTGGGATACAATTATTGGCAGGCACTTTAC AAGTGTCTTTTAATTCCCCACTTCCCAGACCCCACAACAAGGTTCTTGAACCAAGTCCAA ACTCCTGCCCCCGAGCTCCATGCCTGCCCACTCCACACACACTAGGCTCTCCCATCCTTC ATTTCACAGCCTGGCTCAGGGCTCCTGTGCGCCCCTGCACACCTGCTCTCCACCTCAGCT GTCCCCTTCCTTTCCCTGAGCTTTTGCACAGTTCCTCCCTTCCCCTGCATTGGAATGCCC TGTGTCCAGGCCCAGGCAAGACGGTGAATTATGTCTGGTTTTGGAACATCTCCCTCTGCA GCCTCACGGACCCCCTCTTTGGCCTGGGCCCCAGGATCACCTGGTCAGGGGGCTTCAAAT TGTATTCCACAGCCAAGTGTCCTCACAGAAGACCAGAGGGCTGCTATGGGAGCCCCCTTC AACCAGTGCCATTTGGCTCTTTTTGTTTGTTTGACTTTTTTTTAAGTTCGGGGTACATGT GCAGGATGTGTGGGTTCGTTACACAGGTAAACATGTGTCATGGAGGTTTGTTGTATCAAT TATTTCATCACTCAGGTATGAGAGACGTACCCATTAGTTATTTTTCCTGATCCTCTCCCT CCTCCCACCCTCCACCTTCTGATAGGCAAAATGCCATTTTGCTTTTACTGATTGAATTTA TTTTACTTCCAAGTAAGATTTGGTTAGGACAAAGGATTCAACCAAATAATATTAATTAAA TATTATTTTAATTACTTATTATTAATAATAAACATCAAGAGGAAACTCACTGATTTAACC CCTAATTTTGCAGAGAGGAAAACCAACCCAGAGAGGGGAAAGACAGACTAGGGTGAACAC GGGATTTGCCCTGCCTTGCGGCTTATTCTCTCCCACTCAAGGCCTCCCACTGCCCCACCC TGGAGGTGCCAGTTGCATTGCCATCTGTGGATGGAGTTGTGCCATGTGGCAGCTACCCGT TTTCCAGCATCCACTCTGCTCATTCACTTTCTAGGCCTTCCTCTCTCTGAGCCCTTCAAT GACCACCCTTATTCCACAGGATAAAGTCTAAACTCAGCCTGTCCTTCAAGGCCCTCATGA GTGAGCTACACTCTCACTTATTTTTTTTTTTTTTTTTTTGAGAAGGAGACTCATTCTGTT ACCCAGGCTGGAGTGCAGTGGTGCGATCTCGGCTCACTGTAACCTCCGCCTCCTGGGTTC AAGCAATTCTTCTGCCTCAGCCTCCTGAGTAGCTGGGACTATAGGCGTGCACCACCATGC TGGCTAATTTTTGTATCATTAGTAGAGACGGGGTTTGACCATATTGGCCAGGCTGGTCTT GAACTCCTTACCTCATGAACTGCCCGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGCAT GAGCCACTGCGCCCAGCTGCTCTCACTTTCCAAACATATTTCCTATGGACTCCATTCTGT TCTCCACTGGGATTGGCAAGCTTTATCTGGAAAGGGCCAGATAGCTTTGTAGCTCACATA AGGTTTCTGTTGCAAATTCTTAAAAAAAAAAAAAAAAAAAAAGCTTACAATTCTTTAAGC AAAAACAGGCTGGGAGCCAGGTCAGGCTTATGGGCTGTAGTTAGCTGACCCCTGCCCTGC AACCCTGTCCCATCTTGACCTGCTGGAATCCAATGTGTCTGATTTCTTCCTTTTGTGTTC TGACTCTGTCTCCTAGGCTGGGCTCCCAAGGCCCAGCTGGGCAGGGGCAGGGGTTTCCAC TTTCCCTTATGAATGATTCCTCTGTGCCCCCTAGGTGCTGTCTCACTGCCACCATGCCGG AAGTGTAAGTAGTCTCACTGCCATCTGGGGCCCCAGGAAGGCAAGTCCCTTTGCCACAGA CTTCAGCCCCGCAGTGGAGGCACCATGTTTTCAACCCCCAAAGCTTTTCCCTAAGAGACC AGGTCCTCAAACAGGGGCAGCACTTGATGGTTTCCCCTGTGCTGCCTGTGTCCTCCCAGC CATTGAGCAGAACTCACTCCCAGGTTGCCCTGGGAGTGCCTTTTTGGCTTGTGCCTCAGA GATTTCCTGTCTTGATCTATCACATGAATTGCATGTACCAGGCCACCACTTAACACTGGT GCAGTAGGTGAACAAAGCTTTGGGAATTTACCCACGCACCCGTGGATGGATGCTTTCACG TTGCTGGAACCCTACGCTAAGGCTTCCCTCCCCTTCCACCACTTGTCCCCAACTTACGAT GCCCAGTACCTCCCAATAAGAATGCCCCGTAGTTCAAAGGGCTGTTGAATTTTTATTTTA TTCTGCCGGAACCTCAAACCGCTCCCCTTGCCTGATGCCTGATGACTTTCTGGCTCACTG TTGTCACTGGCCCCCTCCTCCCCCAAGCTGGTCTGTGAGGTTCTGCGACTGCACATGTAA TCCTCATTGTTCATACTCACTCTGTGTTCTGCTCTTTCCCCGTCCTTCCTGTGATGGATG CCTGAAGCGAGGTAAGTGATATTTGGGGTATCTCTGTCTTGGTTAACTCTAACGACTGGT AAAAGTGGGAAGGTGGGGTTGGCATCTGAGGAGAGGGAAGAGCCTGTGTTAAGGCCTGGT GGGAGTCCAGGGGGTGTAGGGTATTTAGTGGCTGAACAAATTCCCAGGAGATGGAAACGT CAGGTGAAGATTCTGGATGTGGGGCTTCCTAGTGTCCAGGGAGTTGCTGTGCCAGTGTAC CATGTCACTGGAAGGACTGGTATTGCAGCAGGGTTGGGTGTGACTCTGCATCCTTGCTGA GCACAAGCTCTTCCTCACCCACTCTGAGAGCTGGTCCAGTCCTGGGGGGACCATCCTATT CCATGCAGAGCTGATCCTGTGCAAAGCTATATTGGAAGGGTAAGGGATAGTCATTGGGTT ATTCCACCCTTGCCCAATGGCTGAACATTGATTGAGGAGCAAAGAGATGTCCTTAAATCC CTCAGGTGTTAGAAAACCCTGACACTGGCCATTCTATACACTCCAGACTTACCAGGCTAC TGAGATCACAGCCTATGTACAGTCCAAGGATGGGGATGGCAGGGATAGGGATGTGGGCCC AGGGATGGAAACAGTGAGAATTAGCAGTATTGATGGAGGGGATATTTGGCACAGAGATTC TCAGTAAGAATTGAACATGTTACTTTTCAACATTCATATGAATTTTTAAGTTTTGCTGAG GCTCGTATTAAAGTGAGTCCTCACTGACTGATGGTCAAATGAGGTGGCCATCGGCTCACC AAGTGGTGGGGAAATAAGATCGCAGTCAAACATTTGCCATGTGTACATTACAGTGTGTAA ACCATGGTAGTAATGCTTAGAGTCATAGGCTCTTTCTTTTGAAATTGCACTTATCTGAAA TGTAACAAAAATCTTTAGGAGAGGAAAAGACAAACCAACCACTCTGAACAGTCAGAATAG AAGTTACACATTCCATTTGCTGAAACTCATCCATTGTCTCTCATGAGAACTTCCCTCTCA AAGCCTAATCACTTCTACTTGACACCCTGGAATAACATTTGAGAGCCATGCTCTGCCGGC TCACAGCACATTAAGTCTAGGTAGGATGCTTCCTGCTGGCAATGAGAAGTGACCGCCTAT GGCCCAGAAGATACTCTAGTGCTCGAAAGGCATCACAGTCTCATTAGTTGGGGACCAAGC AGCCCTACTACTCACCTTTGCCAACCCTGAGGGACCACTGTCACAGGGCTAGGACTAGTA AGCAAGAACATGTTTAGGATTTTTGATAAGAAGATAAAACAGTGGTTTTATATCTTAGAA AGATTTGTATGGGTGGTGTTAACATTTTTAAAAGTTTTGAGGTCTACATAGATACGTTTC ATTTATTTGGGAAATTCACAGCTTATTTATGCAGCATGACGGATCATCAAGGTATTGCTG TATTACTACCTGGAGTGTGAAAACACATAGCTTTTACGATTTTCAAAGGATTTGCACATC CATGATCTCATTTCATCTGCAATAACTCTGTGAACTAAGTAAGGGGGGGGGTCCTAATAT CCTTATTTACAGATGAGGAAGGAGGTGCCTGTAGAAGCCATGTGGCCCTCATAGTATCTT ACAAGATTTCAGCAGCAGCAGAATCAGAGTGGGAAGTTAAGGCTTCAGCCCCTAGGTCAA GGTAGCTGACTGCAGCCTTCTCTGAACTGCAGAGGTTAAATAACAAAGATGAGCTTTTAA GGCACCGTAGGGTGAGCAGAGGATTCCGGATAAAGATAGAGAACGCTGGCTGGCACTTGT CTTGTCCTAGACCAGAATTCCAGTTCTGCAGCCTCTGCCTCACCACCTGTCTCTCTCTCT TCTTGCCCACAGAGAAAACCCAAGATCACTGCCTCCCGCAAACTCTTGCTGAAGGTGAGG CTGGGGGCTGGCTGTGGGGGGATGCCCAGTGGGAGGCAGAGGGGCAGCAGAGCAGACTCT GAAGGGATGTGGAGGATTATGGCAAGGAGAAAGGAAGGAGGCCAGAGTGAGGATGATGAG GGGCAGGAGTCCAGCATTGCTGGAGCCAGTGCCAGGCTCAGGTGATCAGTAGGTGGGATC CTCGAGTATGGATTCTGGCATCCGCCTGTGGTCCCTAGAGTAGGTGGTGACCAGCTTCAG AGTGGGAAGCTACTCATGCAGGCAGAGGGACTTCCTTTATTTTCATATGTGTTTCTCTCT TTGGAGTTTTGTGGGTCAAAACAGACAGTAAGTGGATAAGAGGAAGACTGTCCGGGGAAA ACAAGTTCCAGGGCTTGAGGAACATTGTGTGCAGCCACTGGGTGTACCCTCATGGTGGCC TGTCCATGGCTGCTGCATACACTTCTACACTGGACAGTGGTCTCAGAGTTGGCCCAGGCT GTGGCTGCCCTCCCCTCATTCCCTGATGCCGGGTGGGAGATGTGAGGCCCCCAGCTCAGC AGGTGTGTCCTGTCCAGAGCCTGATGCTGGCCAAGGCCAAGGAATGCTGGGAGCAGGAGC ACGAGGAGCGCGAGGCTGAGAAGGTGCGCTACCTGGCAGAGCGCATCCCCACGCTGCAGA CCCGTGGCCTGTCCCTCAGTGCCCTGCAGGTTAGCCTGGCAGGTGGGGCGGGGCAGGGTG GGGCTGGAGGTGCTGTGTGGGTGGCTCCAAGGACCAGGCGGCAGGAGCCTGAACTAACAC CAGCTCAAGGCTCCATAATTTACAGGGCACTCCTCCCTTACATGGTCTCATTTAATCTTC ACAACCACCTGTGAGGTGGGAACATTAGATTCCATTTTACGGGCACTGAACTGAGCATCA GAGGGGAGGCGTGACTTGCCTGGGCTGGGCGGCCCAGCTTCACAATCAGCCAGTGTGGTG GCATGGAGTGGGGAGGCGGCCGGGGTTGGGAGAAGCCCCACTTTTCCAAGGACTTGTCTA CCCTTTCCTAGAATTTGGTCTTCAATGTTTTCAGAACACTGGTAAATTGGTTAAATGCCA GTGATTATAGAGAAAAGAGACTGGAAGGAAGTATATCAAAATGTTACTAAGTATCCCTGG GTGGTGGCATCACTAGGTATTTTAATTTTTATTATTTTTGTTTAATACATAGTTTTCAAA ATGTCTAAAATTAACGCATTACTTTTATCATAAGAAAACTATTTTATTTTGCTGGGCACA GTGGCTCATGCCTGTAATCCCAGCATTTTGAAAGGCGGAGGCAGGAGGATTACTTGAACC CAGGAGTTCGAGACCAGCCTGGGCAACATAGTGTGAGACCTTTTCTTTATACAAAGTTTA AAAAAATGAGATGGGAGGGTCACTTGAGCCCAGGAGGTTGAGGCTGCAATGAGCCATGAT GAAAGAATACTTTTTTTTTTTTGAGGCAGAGTCTCATTCTGTTGCCCAGGCTGGAGTGCA GTGGCGTGATCTTGGCTCACTGCAACCTCTGTGTCCCAGATTCAAGTGATTCTCCTGTCT CAATCTACTAAGTAGCTAGGACTACAGGTGCACACCACCATGCCTGGCTAATTTTTGTAT TTTTAGTAGAGACAGGGTTTCACCACATTGGTCAGGCTGGTCTTGAACTCCTGACCTCAG GTGATCCCCCACCTTGGCCTCCCAAAGTGCTGGGATTACAGGGATGAGCCACCGTGCCCA GCCAAGGATACTAGTTTTTTGTTTGTTTGTTTGTTTTTTTGAGACGGAGTCTCGCTCTGT CACCAGGCTGGAGTGCAGTGGTGTGATCTCAGCTCACTGCAACCTCCGCCTCCTGGGTTC AAGCGAAGGAATACTATTTTTTAAGAAATCATGACATTCAGACAGGAGAACAGAGGGCAT ACCCTTTGAGCTATTGCCCGTCATGAGCCTCAGAGTGGAGGAGACTGTCAGCTCCTCTCT GGATCCCAGGTCTTGCAAAGGGGCTGGGGAGAGGGTCAAGGGCTGGAAACTGATGTCTCT GTTCCCCTCTTCTTCACACCTGCATGATCCATCTGCGGCCCCCAGGACCTGTGCCGGGAG CTGCACGCCAAGGTGGAGGTGGTGGATGAGGAGCGATACGACATTGAGGCCAAATGCCTC CACAACACCAGGGAGGTGAGTCTAAGGAAGGGAAGGGGCATGGCCATAATGGGTTGGGCA GGGGCATGGGCACGGATGCAGCAGCCATGGGAGGTCCCCTCCTTCCACAGGGCCTAGGAA GGGGCCACTTAAGCAGGAAACTTTGGTTTGTCTGCCCTAGCCCCATAGGGCTGGAGATGG GTAGAGTGGATAATCACACATGAAAAGTACAAACTTCCTCCCTACCTGCCATGTGGGCTC ATCAGCCTAACAGAAGCTGCTCTCTTTATCCACCCACACAAATAATCATATGCCTGTTAA TAACGTCTTACCTTTGTGAAGTGCTTTCATGTTCGTTATAGCCTTTGATCCTCCTTATAG GCCTGTGGATGAAGTAGGGGCTATTATCTGCACCTTGCAGAGGAGAACACTCAGGATCAG AGAGGCCAAAGACTTGTCCTAGGTTGCACAGTGGTGGTCCTGGGACCAGTGCTGGTCTCT GGCTTCCACTCCGGTGCTCTGTGCTCCCTTAGCATGGGGTGTGGGAGGATTAGCTCCACC CAGACCCTGCTCCAGTGGGGAGGGGCAGAGCAGAGAAGGACAGGGCTCCTTTGGGGCATT TGTCCAGGCAGTGAGGAGGGGGCAGGGAGGGAGCACAAGCCACTTCTCTCCTTCCCACTT CTGCCCACCAGGAATTATATGTGGGGTCACCAAGCTCCTAAGAACTCCCCCTAGAGATCA CACCCTGGGAATTCCTCCAGGGGTCTAGGACCTGTAAGTTTATCACCCTGCTGGACCAAG GCTGTGAGCTGCTTTGAAGGCTCACTGGGGAGGAATAAGTTAGAAGCAGGGATGAGGCTG CAGGAACAAGAGGAAGCAGCCCTGCACTCCAAATAGGGCTTCCAAATCAGACAAGTCTCA GTCTGGTGGAGCCGCCCCTTTTATTCAAGGCTATAGTGTTAGCAACGGCTAATAGGCTTT ATCTGTCCACTTAACCATCCGTTTATCAGCAAATGTGCAGTGGTTATTTGCAAAGGGATG GGTGGGTCTGACTGTCCTAGAGCAGGGATCTCCAACTCTTGGGCTGTGGACCAGTACCTG TCCGTGGCCTGTTAGGAACTGGGCCACACTGCAGCAGGTGAGCAGTGGGCAAATGAGCAT TCCCGCCTGAGCTCTGCCTCCTGTCAGATCAGCGGCGGCATTAGATTCTCACAGGAGTGT GAACCCTATTGTGAACTGTGCATGTGAGGGATCTAGGTTGCACGCTCCTTATGAGAATCA AACTCATGCCTGATGGTCTGAGGTGGAACAGTTTCATCCTGAAACCACCCCACCACCTCT CCGTGGAAAAAGTGTCTTCCACAAAACCGGTCCCTGGTGACAAAAAGGTTGGTGACTGCT GATAGGTCTGGCTTCAAGGGTGGACAATTTAAGGTGTATCTCTGGCTGGAACCCTAGCAG TCTGAGGTCCTCAGGAAGGGTGTCCTGTGGCTAGCTGCCTCTCCAGTGAGCCCCGGGCGC TTCTCACCTACAGATTAAGGACCTGAAGCTGAAGGTGATGGACCTCCGTGGGAAGTTCAA GCGCCCGCCCCTGCGTCGAGTCCGTGTCTCGGCTGACGCCATGCTCCGGGCCCTGCTGGG CTCCAAGCACAAGGTGTCCATGGATCTGCGGGCCAACCTCAAGTCTGTGAAGAAGGAAGA CACAGAGAAGGTGAGGTCCCTTTCCTCAGAACATTCCACCCTCTGCCCTACCAGCTTTCC CCTTGTCAACCCCTCACATGGCCTCAGGCTGGCCCAGGAGCTCCTGTTGGAGACCAGTCA GCTTGACAGACAGAACATTCTAGAATGCTTTGGGAGACCAGTGTGGGAAGAAAGAAAGAA GATTTGCTCCCTTCCTTCAGGCTGTTCCCAGTCTGACGAAGAAACTAGGACATAAAGAAA GCTAGACCCCAGACGGAGAAATGAAGTAAAAATCTTGTTCCCAGTGTGAAGATAATGTGG AGATTTAGGGTAATGGTGGAGATGACTGCCTGGTCACCACAGGGAAAGGAGACAGCAGCT CATCTTGGTTATAGCCACACACGAGCATAGACATTAGAGAACTGAGTTCAACCACCCAGC AACAAATTATTCAAAGTTGGTTGAATTCACAGTATATGTGCCCCAAATTGATAGGCTCTG TAAGGAACAGGGATGAAGGAACAGTCTCTGGCCCAAGAAGCTTCAGAGGAGAAGAGATAA GCCAGACAATATACTGAGGAAATGGAAAAGCAGCCGCATTTGCAGGGGAAGACTTCTTGG AAGAGGTGGCCTTGAGCCTGCTGAGTGCCAGACCAGGAGGGTGGCATGGAGCCTTGGAGG AGGTTTTGCTGAGGTGCACTGAGGTGGGAACTAGCCCCATAGCTGCCACTTTCACCCAGT GCTCCCAAGCCACACAGCTTCCTTTTTCCTGTGGGGCCTCGGCTTGGCCTGTGTCCACCT GCCTGGCTGAGTCCTAGGACCTTACCAGCTGGGGAGGGGCATCAGGATTTCTTATCATCC GAGGAGACTGGTTTCCTATCACCCAGCTTCTCTTGAGCTGGGGGGCCGTCCAGCCTGGTA AGTCCCTGATGTGTGTGCCACTTGTCTACAGGAGCGGCCTGTGGAGGTGGGTGACTGGAG GAAGAACGTGGAGGCCATGTCTGGCATGGAAGGCCGGAAGAAGATGTTTGATGCCGCCAA GTCTCCGACCTCACAATAGAGGTACCTAGAGACCAGCTCCCTTCTCTGGGGTCCATCAGA GTCTAGAGGATAATGAGGGAGTCCACAATGGGCAGGCGGGTTGTACTTAGTGTGGTGCAC GGATGCACGGACTAAGGCACCGATGAGACTGATTTGAGTCGGCTCTCCTGGGCTCAGTCC TGGCTCCAGCACCATGATACTTGGGCATGTCATTTCTGTTTGGCGGCCCTTTTTGTTCCC ATTATCTATGAAATTGGGGGCTGTATCAAATCAGTGGTTCTCCAAGTGTGGTCCTGGGAC CAGCAGCGTCTACATCACCTGGGATGCAAATGATCAGCCCCCACCCCAGATCCACTAAAT TGGAAACTCTGGGGTGAGGCCAGCCTTCTAGGTGATTCTGATGCACATGAGAGTTTGAGA ACCACTAGGTTAGAGGGTCCCTGGGATCCCTTCATCTCTGACTTTCTGAGAATCTATGCA CTTTTAAATACCTCCTGGTGATGTCCTTTATTTGTGCTCCCTGCGAAGTACCCAGCACTC ACAGTACCTGTTCCCAAGGAGCTACCACTCACAGAAGCTAAGACTTCCCACCATCTGAGG AAATAGCTGGAGAAACTGGGCAAAGCAAGGAAATCAGGCCACGTAAAACCCTCTACGGAA GTGCTGAGAGAATGTGCAATAGGGCAGGCATCCACCAGACAGCACTGGTCAGAGCAGGCT TTCTGGAGAGGAGGAGCTCTCTGAGGATGCGACGAGCGAGTGTTAGCTGATAAAGGGAAG GGCATGTTGAAGGGCTGATGGTGCAACAGAAGCATGGAGGTGGGAATTAAGCAGCCACAG AGTAGCATGGCAAGGCTAGGTAAGAGCTGAGGGCCGCAGTGTGGAGGAGCGGTGTGAGGG GTCCCAAAAGGGGAGCAACTGTGCCCGAGGGCCGAGAAGCTGAGGTTTTGTAGGAGCCCT TATGAATGAAGATCCAGTCCGGGGTGCGCTAGGGCTGAGAAGCCCTGGGGACTGCATGTG CTGTAGGTAAGTCAGGGATTCATGCGCTGCACACAGGTCCCCGGGAACTGATGGCTTTGC CTCTTTGTCCCTACAGGCCAGCTTGCTGTGCTGCGCTCTGAGCTCCTGCTTCATGCTTCT TCTCCAACCCAGCTCACTCACCTCTCTGCCTGTGTCTGGAGCATCCCTTCCCACCTCTCC CCCACTTCTTCCCTCCAGCCTGCATGCCCTCCTCTGGAACTGGGATTAAACAGATACCCA AGAGGCAGGAAAAACGCGAGTGTCTGAAGACCTCACCCTGGCAGGGTGGGCTTCTATCCA CCCATGAGGCACCTGGGGCTTCTCAGCCACCCCGTGGTGTAACAAGTGGAGGAGGAGGAG GGGGTGAGAACACCTTTCCTCCAGCCCTGTGCCACACTCCTTCTATGTGTGTACAGTGTC CACAGGCATCACACCTTCTTCATTAAAAACCCAGTTTCCTGGTCATTTCTGCAGCTCTGA CTGTGAGCCCTGAGAAGAAAGGGAAGACTTGGGGCTTGGGAAGAGAGGGCTGTGCTGGGC TCCAGTCACCCTGTCTGCAGTCCGGAGCTCGGGATCTGAAGGGAGGGCTAAGGAATTGGT GGCTGCTTGCCAGGGTCCCCTGGGGCCCCTTCTGCCCAGTCCCTGTGACGTCACACTGCA CACACTCACCACCCAGGATGCTCAGCTCACCAGAGCCCTGACCTCCGAGAAATGACCCCG TCCTGCCCCTGACTCTGGCCATCAGAAGAGGCCTCTCCATTAAGAGCCGCTTCTCCTGCC GGCTTTCATACTCTCCTTCCTCTGCAAACCTGGATTAACTCTCCCTGATGTGTGCTGGGT TGAGAGGTCAGGGCACTTTCAATCCCTCACCTAGTCCTGCTGCACAGGGCAGGAGGCCTC ACAGAAGAGATACTTGCAGTTCCAGGCCTGGCCACCAGGTGACGCCTTCCTTCTCTCCTG GGCTCTCCTGTCCCTCCGGCCTCTGCTCTCCCCACGTTCACCCACCCTCCTCCCAATTGT TTCCCCTTCACACTCCTGCACTGGTCCTATCCCCCAGGACTGATTCTTTCCCGGAGATGG GGTGGCCACTTATCTGTCCTCTGGATCAGGTCCTTTCTCCATCCCACTACCTCCTGGGTC CAAAGCCTGGTGAGAGCATAGGGCCTTCTGGGGTGGAAGGGGGGTCTGGGGCAGCCTCTC TTCCCCCAACATACTCACTAGAGTGGCTCCTGTGAAGCAGAGACCAAAGTTCTGACTTTT CTTTTTCCTTTTTTTTTTTTTTTTGAGATGGAGTCTCGCTGTGTCACCCAGGCTGGAGTG CAGTGACGCGATCTCGACTCACTGCAACCTCCGCCTCCCAGGTTCAAGCGATTCTCCTGC TTCAACCTCCTGAGTAGCTGGGATTACAGGTGCGTGCCACCACACCCCGCTAATTTTTGT ATTTTTAGTAGAGACAGGGTTTCACCATGTTGGTCAGGCTGGTCTCGAACTCCTGACCTC GTAATCTGCCCACCTCGGCCTCCCAAAGTTCTGGGATTACAGGTGTGAGCGACCACATCC GGTCAAGTTCTGACTTTTCAGGGCAGTGGGATGGTGACTTCTGAGCTAAGCCTGCAAGGG AAGTGGCTGTTCCCAGACCTGGGGTCCCTTGGCTTTTCGACCACCCTAGCACTGGCCCTA GGAGGGGCTGAGTTATCAGAGCAGCAACCCTTCTACCCACCCTACTGAGTCCCCATTCTA CCTTCGAATCCCATGTATTATCTTCCATAAGTGCCAGAAATTGGTACAAAGTGCAGTGCC AGCTGCTCCCCAGGGCATGGTCTGGCTCTCTGGGCTGCTGGGCTGCCAGCCCCTTTCAGA AAGCATGGCAGTGGGAACCAGCAACTTGGGCTACCTTAGGGGAAGCAGCACTCTGCCCAG GGTTCTTGCTATAAATAGGTCAGTGGGCAGAGAGGCAGATGTGTGCAAAAAGCACAACCC CAATCACACACAGAAACCCGTAGGCACGGACACACCCAGTCTCAATGCACGAAGTTGGAG AACCTGACAGGGCTGGTCCAGGCCACAGAGGATGGGGTTAGGCTTCATGCCTTCATGCCC AGGCAGCCACAGAAACCCACTCTTCCCCGCCTCACAGGGCTCCTCCGGTTGGCCTGGATC CAAAGCGATCTCCTTGTTTCACCTCTTTCCAGCTCTTCCCTAGAGCCTGGCCCCAAGTTC CAGAGTCAAATCCCAGTTTTGCAGTCAACTATTAACCTGGGGCCCTGGCAGATTGGGGTA TCCACCCAGTCATGTAAAGGCAGGAGACCTGCTCTGGGCCTGACTCAAAGCAAACACGTG GGTGCAGAAGACCCATGGGAGGAGGAGGTGGGGCCCACTCAACACACCTAAGCCAGTGGC CCTCTAGGAGGGGCAGAAGAGCCAACCAGAGGGTTCCTGGAGGTCATCGGGTTCCTCCTT CTGCTTCCAGGCAGCAACAGACCTAATTCATCTCCTGTGAGGATGGAGCAAGGGCGAATA TAGGCATAGACATATCTGGAGCGCAAGGATTGAGAGGCCCTGTGGACAAGGGGAAGGAGA GCTTGGGGGTGGGAGAGGGATCTATGGAAGGGGCTGTTGTAGCCAAGAATGGGGCCTGGG CTGGGGGCCTGGCCTCTGGAGAGCCCTGATTCTACTCCAGTCTTCTCTCACCATGGAGAC AACACCAGTAGAGCTGGGAGCTGGGGCCTGCCACTGAGTAACAGCTCACACATGTAGCAC ACTTATGCGTCAGGCACCAGCATGTACACCTTAATTTATTTAACTTTCACAACAACCCTA GGAGAAAGGTACAGCTACTATTCTCATGGTACAGTGGGGAAAACTGAGGCACAGAGAGGT TAGGGACTTTTCATGATCACACAGCTAATAAGTGGTGGTCCCAGGATTCAACCCAAGAAG TCTGTTAGAATCCATACTCTTATCGACTATTTTAATAACAGCATTTCAATAATAGTAATA TGTGATGTTAAATGCTTTATCTGAGTTATATCATTGCATTCTCACAAAAATGGTACATTT GTTAGCTCAAATTTACAGATGAGGAAATGGAGGCCTGGAGAGTTCAAGTAGCTCACTCTA AGTTACAGGGTTTGCTAGCTGCAGACTGGAGACTAGATCTCAGGTCACTCTGCCTTGGGG TTGCCCTTTTCTGAGATCAGACTGGCCTTAACAGAGCCCAACTTTCTTGGAAGGACACAG CTGGGGGTCGAGGGTCCTGCATATGCACCTGGGGAGTCCCCACACACCCGCACCAAAGGG GAAACATTCAAAGGAGATGCAGGTGACATACAGATGGGCTAAGGTGAGGCCTTCCTCCAA CATGGGGCCCTGGCTGAGAGTGGAGGGATAGGGTGCTACTTGGGGGATATCTATTACTAA TCAGCACACAATAGCTGGGTGGGCACCCCCTCTCTCTGCAGCTGGTGGAGATGGGCCTGG TGCTCCTCTCTGCTTGGTAGGAATGACCAGGGCAGGATGCCACCTGCTACACTCTTGCCT GTCCCAGAGCCCTTGGGAGACCAGCTGTTGCTCCCACCTTTCCCCACAGGGTGCCCGGTC CCCACGGCGCAAGGAGGCCAAGCTCAGCTGTGTGTCTGAGCCCACTCAGCAGCAGGCATG ATCAGGGCAGGGCCCAGCGCTAAGGGCTGCTGGGGCTAAAGTGCCTTGCTGAAGGAGGGG CAGAGTTAAACATTAGCCACAATGGCCCCCCGCGAAGTGAGTCATACTCCCCACAAGTCT CTGGGCTGGGCAGCCGGGGGCGGGGGGGTTAGCTTCGTTCCAGGTGGGTGACCAAGCTGC GGAAGCCCAGGACAGTTCGCTGGGACCAGTGCTAATGGCAGCTTCTGCTCCTGACCCCCA TCAGGTCTCTTTCCTCAGACATCCCCAAAGCTTGTCTGCCTGTGGGTCTTTCATTAAAGG TGACGGGCAAGGGTTTTCTCTTCCTTCCAAGACACACTTCTAGGCTGGCTTGTGGGTCCC CTGAGACGAAGGCTGAGCAGGGTGAGCCTCGAAAACCCCATAGCACTGGCCCAGAGCACT GCGGTCAATGTCCGAAGGACCAGAGAGGGAGGGTGACTTGCTCAAGGTCACAAACCTAAC TGGAGCTAGGAAGTAGGTCCCCAGACTCCCAGTCTGAGGAAATTGGATGTGGACAGGGCT TTGGTCTCCTGGCCAGAGGCAAACGCCCAGGGATCTGAACAGGCTGCCCATCTCTGGCCT CAACTCAGCACCCCAACTGGCTCCAGTGCCAACCATTGGCCTCTCTCACTGGTTGGCACA GGCTGGGTGAGCCTGGCCCTTTGCCCTGGGTTCAGGAGAGAGGTATGGCTTTGCCTGGCA GTCAGGGGAGGTGTTCCAACCTGGGAGCCCCTGGGGGAGGAGCGTGTGTGTGAACGCTTG TGCCTGTTCATCAGAAGGGGTGAGCATGGTGTGTATGCGTGGGCATGCAGAATGCAGGGT GATGACCTGTCTGCCCGCCCTGAGTGTCACAGACACCTGTGTGTCCCCTGTACTAGTGCC TCCCAGATGCTCTTCTCCTGACTGGCTCTTTGTGACCTAAATTTCAACTGCTCCACCCCA CAAGGAGGAAACCAGGGCCACAAATGTAGTGAGATTTTCATAAAGCTAAATGTATTCAGT GGAAACGACCTTCCTCTGATCTAAAAGCATGCATGCCTTTGTTTTATTACTGGAGTATTA AATTAGCCCTTACTTATGGAATAGGAGGACAGTAGGTGGCAATTGTTTTCTAATGCTCTT ACTTCACAAAATAAAATGGTGGCAGCACAATGTCAGTATTTATATTACACAATATTATTA GTTTGTAAAAACCGAAAGCCAGGGAGCTTACTGCCCTGGATTCTTTAGGGCGTGGGTCTT ATCACCTCATTCATTTCTTCCCTTCCCCTAAGAGTGCCACAAGCATGGCAGTTGCTCAGC TGAGACACATGAATGGGAACAGAACTGAAATATCAGGATGTGACCTCGAGCCAGCTGGTT GGGGCTGGGGATCCCCCTGGATCTCCACTCTGTCCTGTCCGAGAAAGGGGAAGCTGCCCT ATGAGTCTTTTTTCTGGGGGATTCCAGAGGTTGAACGTCTGTTCTGAGGCTCCTCAGAAC CTCGAGGGAGGGGACGAGAGAGATGACCCCTTGCCCAACCACTGGCTGAAAAATCTTGAA ATTCCCTGACTTTGACCAGGGAATTCCCAGTTGTGCTAAGCCCTGCCTGGTGGAATGTCC CTGGAGGAAGTAACCAGGACACGCATACGTTTTTAATGTACGTATAAAGAATCGTAAAGT GAACACCCATCTGCCAACCACTCATTTTAAGAACTAGGATATGGCACATACTTTTGAAGC CCTTATGCGTCCCTCCCCAATCACAACCCCTTCCTCTCCACAAAGGTAAATACAATCCTC AATTTTGTGTTTGTTATTCTCTTGGTTCTCTTCATAATGTTACTACGTATTTATGAATTC CTAATACATCATTCAGTTTTGGATCTTTTTGTAAACCTTA OMIM ID 191042