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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for STAT5B (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID6777
Official gene symbolSTAT5B
Full namesignal transducer and activator of transcription 5B
Aliases,STAT5,
Gene summaryThe protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL. [provided by RefSeq]
LocationChromosome: 17   Locus: 17q11.2
Gene position40428424 - 40351195  Map Viewer
Gene orientationminus
Gene size77230 bp
Gene sequence
OMIM ID604260