| Entrez gene ID | | 6573 |
| Official gene symbol | | SLC19A1 |
| Full name | | solute carrier family 19 (folate transporter), member 1 |
| Aliases | | ,CHMD,FOLT,IFC1,REFC,RFC1, |
| Gene summary | | Transport of folate compounds into mammalian cells can occur via receptor-mediated (see MIM 136430) or carrier-mediated mechanisms. A functional coordination between these 2 mechanisms has been proposed to be the method of folate uptake in certain cell types. Methotrexate (MTX) is an antifolate chemotherapeutic agent that is actively transported by the carrier-mediated uptake system. RFC1 plays a role in maintaining intracellular concentrations of folate.[supplied by OMIM] |
| Location | | Chromosome: 21 Locus: 21q22.3 |
| Gene position | | 46962351 - 46934629 Map Viewer |
| Gene orientation | | minus |
| Gene size | | 27723 bp |
| Gene sequence |
| |
| OMIM ID | | 600424 |