| Entrez gene ID | | 6405 |
| Official gene symbol | | SEMA3F |
| Full name | | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F |
| Aliases | | ,SEMA-IV,SEMA4,SEMAK, |
| Gene summary | | The semaphorins are a family of proteins that are involved in signaling. All the family members have a secretion signal, a 500-amino acid sema domain, and 16 conserved cysteine residues (Kolodkin et al., 1993 [PubMed 8269517]). Sequence comparisons have grouped the secreted semaphorins into 3 general classes, all of which also have an immunoglobulin domain. The semaphorin III family, consisting of human semaphorin III (SEMA3A; MIM 603961), chicken collapsin, and mouse semaphorins A, D, and E, all have a basic domain at the C terminus. Chicken collapsin contributes to path finding by axons during development by inhibiting extension of growth cones (Luo et al., 1993 [PubMed 8402908]) through an interaction with a collapsin response mediator protein of relative molecular mass 62K (CRMP62) (Goshima et al., 1995 [PubMed 7637782]), a putative homolog of an axonal guidance associated UNC33 gene product (MIM 601168). SEMA3F is a secreted member of the semaphorin III family.[supplied by OMIM] |
| Location | | Chromosome: 3 Locus: 3p21.3 |
| Gene position | | 50192848 - 50226508 Map Viewer |
| Gene orientation | | plus |
| Gene size | | 33661 bp |
| Gene sequence |
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| OMIM ID | | 601124 |
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