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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for PRDM16 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID63976
Official gene symbolPRDM16
Full namePR domain containing 16
Aliases,KIAA1675,MEL1,MGC166915,PFM13,
Gene summaryThe reciprocal translocation t(1;3)(p36;q21) occurs in a subset of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). This gene is located near the 1p36.3 breakpoint and has been shown to be specifically expressed in the t(1:3)(p36,q21)-positive MDS/AML. The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal PR domain. The translocation results in the overexpression of a truncated version of this protein that lacks the PR domain, which may play an important role in the pathogenesis of MDS and AML. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq]
LocationChromosome: 1   Locus: 1p36.23-p33
Gene position2985742 - 3355185  Map Viewer
Gene orientationplus
Gene size369444 bp
Gene sequence
OMIM ID605557