Database of mammalian genes
Home

Home Search Browse Statistics User guide FAQs Links Questions Contribute Download


Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for SDHB (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID6390
Official gene symbolSDHB
Full namesuccinate dehydrogenase complex, subunit B, iron sulfur (Ip)
Aliases,FLJ92337,IP,PGL4,SDH,SDH1,SDH2,SDHIP,
Gene summaryComplex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis. [provided by RefSeq]
LocationChromosome: 1   Locus: 1p36.1-p35
Gene position17380665 - 17345217  Map Viewer
Gene orientationminus
Gene size35449 bp
Gene sequence
OMIM ID185470