| Entrez gene ID | | 6272 |
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| Official gene symbol | | SORT1 |
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| Full name | | sortilin 1 |
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| Aliases | | ,Gp95,NT3, |
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| Gene summary | | This gene encodes a protein that is a multi-ligand type-1 receptor with similarity to the yeast carboxypeptidase Y sorting receptor Vps10 protein. The encoded protein, a trans-Golgi network (TGN) transmembrane protein, binds a number of unrelated ligands that participate in a wide range of cellular processes; however, it lacks the typical features of a signalling receptor. In the TGN, furin mediates the activation of the mature binding form. The encoded protein consists of a large luminal domain, a single transmembrane segment and short C-terminal cytoplasmic tail. The luminal domain contains a cysteine-rich region similar to two corresponding segments in the yeast Vps10p; the cytoplasmic tail is similar to the corresponding segment of the cation-independent mannose 6-phosphate receptor and the tail also interacts with the VHS domains of GGA (Golgi-associated, gamma-adaptin homologous, ARF-interacting) proteins. [provided by RefSeq] |
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| Location | | Chromosome: 1 Locus: 1p21.3-p13.1|1p21.3- |
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| Gene position | | 109940563 - 109852192 Map Viewer |
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| Gene orientation | | minus |
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| Gene size | | 88372 bp |
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| Gene sequence |
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| OMIM ID | | 602458 |
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