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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for RPE65 (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 6121 Official gene symbol RPE65 Full name retinal pigment epithelium-specific protein 65kDa Aliases ,LCA2,RP20,mRPE65,rd12,sRPE65, Gene summary This gene encodes a protein which is located in the retinal pigment epithelium and is involved in the production of 11-cis retinal and in visual pigment regeneration. There are two forms of this protein, a soluble form called sRPE65, and a palmitoylated, membrane-bound form known as mRPE65. mRPE65 serves as the palmitoyl donor for lecithin retinol acyl transferase (LRAT), the enzyme that catalyzes the vitamin A to all trans retinol step of the chromophore regeneration process. Both mRPE65 and sRPE65 also serve as regulatory proteins, with the ratio and concentrations of these molecules playing a role in the inhibition of 11-cis retinal synthesis. Mutations in this gene have been associated with Leber congenital amaurosis type 2 (LCA2) and retinitis pigmentosa. [provided by RefSeq] Location Chromosome: 1   Locus: 1p31 Gene position 68915642 - 68894507  Map Viewer Gene orientation minus Gene size 21136 bp Gene sequence >RPE65:complement(38866425..38887560):Length=21136 TCCTTCTTCATTCTGCAGTTGGTGCCAGAACTCTGGATCCTGAACTGGAAGAAAATGTCT ATCCAGTAAGTATCTCTGGGAGACTTTTTTAAAACACCTTCATGGATTCATGATAAATGT GCTATTTCAAGGGCTCCTGAAGAGAAGGCATTGATTAATGACCTGTTTAGGAAAGACCCT TGAATTTTGGTGGGGAAATTTTTTCCTGCTTATGTATTAAAGCAACTAGCTAGAATTCAG GTCCAAATTATGGGGGGTTTGTGTGACTTAGCCCGGGGTTTGGAAGCAGTCTTGAGTATG GGGATTTCAGACAGACTTGGGCTCCACTCCTTGCCCAGTCATTTCCTAGTGTGTGACTTT GGACAAATTACCTAACTTTTTAAGTCTAGCTTTTCCTGTATATAGAAAGATGTCACAATA GCTTTTACTCCATTATGTTACTGTGAGATTTAAAAGAGATAATACCATGCAAAGTTCTTT TTATGGTATGTAGGACATAGTAATTGTTTAGTAAAAGGTAATTATTATAATTGAGTCTGG TCAGAGATTCCACTCTTTGAAGTTACAACATGAAACTGAACAGAGGATGTAGAAAGTAAA CAAAAATATAGAACCTGAATCTCCTGGTCTGACTATGATGAAAAAGTACTGTAGGTCTTG GGGATTGGTAGAGAAATGAGATGATGGGGAAAAAATTATGGTATAATATGAGTGAATAAT GAAAGATGAGGTACCTGACCCAAAAAGCTGTCATCTCTCAACCCCTAGGAAGGAGATAAA TGGGTCTCTCCTTGAGGCAAGAAAATCAATGATGCTGTGAGCTGAGCATGTTGATAGGGT GGGAGAATACTGTGGGAAGGACCCTGTTTAGGAACAAATTTCAGGAAGTGAACTGATGGC AGTAGGATTGATTGATTTGTCTTCCGAAGTAAGGAAAAACTGCAGAGGACAGGATTAAGT TCACTGTAACCATTGACATTAAAAGAGAGGTCATGTCTCTTGACATCAGAGCAGTGATCT GGGACCCCCTTCCATACCTGAGTAGTCTTCCCCACCCCCAGCCTCACGTGCTCCTCCCGC CCTCACCTTCGCTTCTCCCCCCACCCCCACCCCCACCCAGCTGAGACTAGACCGGCAGGA GTGAACAGGCTTTGAGCCAGCCCTAGAGTGCCTTCTCTCCTGCAGCTCTGCCTCTATCTC TGCGGACTTTGAGCATCAACATGGGCTTCTTCCTTATTCTTCCACCATTTCAGGGTTGAG CATCCTGCTGGTGGTTACAAGAAACTGTTTGAAACTGTGGAGGAACTGTCCTCGCCGCTC ACAGCTCATGTAACAGGTTGGTCTCGCCCATCTTGAAGCCATCCTCTTTTATGTCAGTCT CTCTTCTCTGGCTTCCTATTCCTTGGCGTCTCTCAGTGCAGACTCCCCCTGTGGGTCACA GGGAGAGGGATCAGGTGGTTTGGGCTTTTTATAGCAAGAACCCATTTTCTTTCATTCGCC TTTACTTTATTTCTCTAATGCAGAAAAACGCTACCTAATTGGAATTCCCTAAGGATCAGG ATTACACCTTTGTCATCTTCAAACTGTCAGTGCCTAGCTCAGTGCCTGGCACATAGTAAA TGTCCTATAAATGTCTGTTCCATTGGTGTCTGAATAAATGAAGGCCCAGTGACAAGCACC TGGGAGTATTAAAGGGTGGTGGGTTTCATGCCCATTTTATTAGAGGAATGTTGGTTCTGC TGGGAGGCAGATGTAGATGCTAACCTAGCTCTATCATTTCACTGTCTGTGAATCCTCTAA GTTACTTAAACGTTCTGAGCCTCAATTCCCTTACCTACAAAAACCCAAAATTTACGTCAT GAGGATGTTGTGAAAATTAAGTGGAGTAATGTAAATAGAATGATTCACCCACTATCCAAC ACAAAGTGATCAATAGACAGTAATTATTACTATCAGTATCATTATTAGTTATAGGAAATA ATCCATTTGCTTGAAAAACTTCACTGGTAGGAATCAAGGAAGCACTGTCAATCACTGCCC TTCTCAAAGGATAAACCTACCTGGGGTTTTTTTTGTTTGTTTTTTTGTTTGTTTGTTTGT TTTGTTTTTTGAGACAGAGTCTCGCTCAGTCGCCCAGGCTGGAGTGCAGTGGGATGATCT CAGCTCACTGCAAGCTCCGCCTCATGGGTTTATGCCATTCTCCTGCCTCAGCCTTTCCAA GTAGCTGGGACTACAGGCGCCCGCCATCACGCCCGGCTAATTTTTCGTATTTTTAGTAGA GACGGGGTTTCGCCGTGGTCTCGATCTCCTGACCTCGTGATCCGCCCGCCTAGGCCTCCC AAAGTGCTGGGATTACAAGCGCGAGCCACCGCGCCCGGCCCTACCTGGGTTTTTAGGGAC AAACCTAACTGTGAAAGCTGAGAGGCCTTAAGGACTATCTTGGGTACCCCACATTTTGCA GATGAGAACACTGAGGTCCAGAGATGACATGTGAGCTGATCCTAAACCAGAAGTCATGTC CCTGACATCCAACCCTGTGGACTTTCTGCTACAGCAGATTGACTTTCATCCAAGCAGTAG CTCACACTCACAGAGGGATATAGCTCTAGATTTTAAAGAGCCAGGATTCCTGTTTTTTCA TTTAAATAGTCTTTTTTCTATAGACACATCTTTTTAAAATACATTTATTCTCACTCTTAA TCCATACTTCTACTCCTCACTCCACTAAAATATATCAAGAAATTTGAAAATCTTCTTAAA AATGAGATGGCAAAAGGCAAATGGATTGGTGTTTGGGGAAATCTATTAGGTGGAGAGTCC CAATCCTCTCAAGATGCTTCTCCCTCACTCCTTCCAACCCTTTATCCACACTCTGGGGCA TCTCCACATTTCCCAAGGTGTGATCTCCTAGTGAAGGTGAGTCAAGTCAGCAGACATTTT CTAAGTGCTGTCCAGCGCGAGGGCTGGAAATGAAAATCACTGCCAGCTCTATGAGGAAGA AGCTGCCCAATCAGGCTGCTGATATACTCTGCCTTACCAAGGACAAGCCTAGCCCAAGGC AGGGATAAGAAGCAATGTTCTGTCTCCCCTTCATCACAGGCAGGATCCCCCTCTGGCTCA CCGGCAGTCTCCTTCGATGTGGGCCAGGACTCTTTGAAGTTGGATCTGAGCCATTTTACC ACCTGTTTGATGGGCAAGCCCTCCTGCACAAGTTTGACTTTAAAGAAGGACATGTCACAT ACCACAGAAGGTAAAGCAGCACTCCATGCCACTCCTCCTCCTCAAAGTAGGGCCTAGCTT GGCTCCTCCTCCCATGTGAGTTTTCACCTCTGAACTCAGGAGGCAACCTATATACCCACT TTCTTCTCACAATGTACCTGGGCCAGTGTGTCTGCATGGATACGAGGGAACATTATCATG GAATAAAGGAGAAGCTAAAGCCTAGGGCTTTGGGGTCCAACATGAGTGGCTTTAAACCCT GTATTCAACAGACATGACTTGCCTAGGAGGGTAACCTTGGCAAGATGTTGACCTCCAATT CTTGGTTTTATAATTAGTAAAATGGGAGAAATAATAGAATCTACCTTATATATTCATTAC AAGCATTAAATGAGAGCGCAGTGTCTAGCACACACAAAGCACTTCATAATAATAGCTATT GTGATGCTTGTTATTATTATTAAACCATTGGCCATCTTGATTCCTTTTTCTTTTTATAAA ATTGGAAAGGCCACTGGGAAAGGGGTCGGGGGCTGCCACAAAGTAGTGAAGGATGAAACA TGTCATAGTGCTACCAGAAAGAGAAGTTTTCTGAAAACAAGAGATTATTGCTAAAAAGCC TTGAAGCCCTAAATCATCATTCCAGGAAACCCCCATTAATGAAGTATTAACAAATACTTT GTCTTCTGCTTTCGTGTTCAAGCCTATTAGTGGCTTTGTTGATCACCACAGATTTCAGGC ATTTTGAAAAGACCTGTAAAGAAAAAGTGAAAGGGGACTTGAAGCAGGACAACTTGCATG ATAATAGAAGAGAAACGGATGATGTCAAGCAGAAATGTAGCCATAAGAGCTTACTGTGGA GTTCAGATAAAGCTTCCTATACCTTCGACAGAGCAGGGTACTCTTTCTTCTTCATAAAAG TGCGACCGGGTGTGGGTGGCTCACATCTGTAATCCCAGCACTTTGGGAGGCCAAGGCGGC CAGATCACTTGAGGTCAGGAGTTTGAGACCAGCCTGGCTAGCATGGTGAAACCCCGTCTC TACTAAAAATACAGAAAAATTAGCCGGGCGTGGTGGTACACGCCTGTAGTCCCAGCTACC TGGGAGGCTGAGGCAAGAGTATAGCTTGAACCCAGGAGGCGGAGGTTGCAGTGAGCCAAG ATTGCGCCACTGCACTCCAGCCTGGGCAACAGAGCAAGACTCCATCTCAAATTAATTAAT TAATTAATTAATTAAAAGTACAAAATCAGATTTTAACTGGCTCTCCATATCAGAAATCCT GGGCAAAGTATGCTGTCTACTCTAAGATATGGTTTAGCAGACCTGTCTAGGCAAGAGATG GAATTCAAGAATACTTAATTTTTAAAACAAAATAAATGTTAAAATTGAAGAAAAACATAA AAGTAACAGAGGGAGATTGAGAAGAATATAATTCAGCACACCATGTCCGGAATTTTCCCA GTAAGTTTAGGTTGATAGGTTATAGGTGATGGGGGTGGGGGTCCTATGTGAACTTCCCCC AGGGCTGCATGGTGTGATATAGAAAGTTCATGTTGTCCTGCTCTGGCCAACTAGGATTCT AACCCAGCTTGGCCACATATGCCAATCACTTAACTCCTCTGAACCTCAATTTCCTCATCT GTGAGGTTTAAAAGATAAAAACGTAAACTCAAGGGACATTGTGTCTGCCCTGCTTGGTCA CCCCAAGAAAGTGAGCTAATAAAACCCTTTATTCTTCATGTTGTGCATTTATGATTGTGA CTTGATGAGGACACATAGAATGGCCATTCTAAGCTCCACATGGGCTGTACGGATTGCTCC TGTCTATACTCTTCCCTATGTTTCAATGTCCTTCAGGTTCATCCGCACTGATGCTTACGT ACGGGCAATGACTGAGAAAAGGATCGTCATAACAGAATTTGGCACCTGTGCTTTCCCAGA TCCCTGCAAGAATATATTTTCCAGGTTACTGAACCCAAACTGAATGTTACTCAAGACATT TTATATTAGCCCTTTTTCTCTCATGGCTTGAAAATTACTGGACTGAAAAATTCATTTGTT TCTACAGGTTTTTTTCTTACTTTCGAGGAGTAGAGGTTACTGACAATGCCCTTGTTAATG TCTACCCAGTGGGGGAAGATTACTACGCTTGCACAGAGACCAACTTTATTACAAAGATTA ATCCAGAGACCTTGGAGACAATTAAGCAGGTGGGACACAGTGCTAGGTGATGTTCAGGAA TTTAGAATTTGGAACTTAAAATTAATTCAACATAAATTATTCATGCTGCGAATGTATGAT TCTAACTTGATGAGGACACACAGAATGACCATTCCAAGCTCCAAATGGACTGCACTGATT GCCTCTGTCTATGATGCTTTCCTGCAATTGGTGTAATTTGGTGAAAAGAACATGAGAGCC ACATTAAGTTTCAAATCCTAGCATTGTCAACAATGACTAGCTATTTGACATAGGACAAAC ATTGTTTCTTCATCTCTAAAATTTTAAACACTTACATGGATTGGAGAGAACCCATATAAA ATGCCTAACATATTCATTCATTCATTCATGACACAAATACTTATCAAGTGCTTTCCATAT TCAGAATTTATGCTAGATGCAAGGGATAGATCAATGAGTAGGGTAACATGGTCCCTGCCT TTCATAGCTTTTATAAGCTAGCATGAACCTGGTAAATACTGGGTGCTCAAAAAATTATAG CTACTGATACTGAAAATCATGCTATTTATGGTTCTAGGCAAGTATGTTGCACTAATTTGC CCCTTCTTATAGATACTTCTTATTAGAAATAAAGCTATATCTTGAATGAAATAGCATAGA ACAAAATTTCAGCAATATTTGGAAGTGACAAATTTTATGGAGAACTTAGGGAATCTCAAT GCAGCAGTCCTTAGATACACATTTTGAACCAATATTTACTAAGATACACCTATTTACAAG GCATTGTTCTTGTCTTCAGGTGACTTAATGTCTAGGTGGAGAAATCAAATATGTAACTGT AATAGGACAAAGAATATGACGAGTCTTTTAAGAAGGAAAATCTTTTAAGAAAGCATAAAT ACGAAAGGAATTACTTCTGGAAGTAGTTGGCAATGCAAGGTGGGACAGGTGAAAGAAGGC TTAAAGGGAAAGGCTTTGGGCTGGAAGTTAAAAGAGAGGGATGATTTCAGTGAATTTAGA GAAAGGATATGCTAGATGGAGGGGGTAAAGCGATCAAAAGCATGGAGGTAGAAGGTGTTC ATGAAAACTGGAGAATAATCTCCTTGGACTAGACTTGCAGCATTTCTCAGTGGAGGTATT AGTATGACATTAGGCAGGGGGTGACTCATCATCATGGAGACGTCCCACACATGGGAGAGG TTTGGCATCCCTGGCCTCATCCACTAAACACCAGTCATGTTTTCAATCATTATACAAACC CAAAACGCTCCTGACATTTCCGTATCTTCCCCTAGGGGGCAATAACACTCCCAGTTGAGA ACTAGTTGCCTAGAGTAGTTAATGTCAAGGGGAATATTGAGACACAGGGTAGGATGAAAT TAAAAGCTTGAATAATTGGCTATACATTTGGAATATGTTGTTTAGCTAATGGGAAGCTAC TGAAAGTTTTTGCTCAAAGAAGTAGTATGAGTAGGGCTATATTTTCAGATGTTTATTTGG GGAGCCATGTGTGGGCTGTACGGGAAGGCAAAAGAGATACAGTATAGCTGGGAGACCAAG AGGTGAAACTAAAAGCCAGAACCACAAATGCAGTACTGGTAAAAATAAGAAGAAAAAAAA TAGTCTCAACATTGAGTCTCAATAGCACAAGCTGATCTATAATTCTCAACAGACTATTTA CTATGTCTTAACATACACTCCCCATAGCTCTTTCTTGTTTATGTTGTGTGTGTGTAACCA TATACAAGTGTGTGTGTAGCTCCTTTAGAGAAGAACAAAAGCTGAGTTTCTAAATCATTC ATTTGACTTTGATAGGGAATCTGTATTACAATTACATGATATTTTAATTAGAAATATAGA AGCTATGGTATGGCTGCAGAATAGACTTTATTAGGAGTCAGGTTCCACTGTTACTAGCAC TGTAAAATGTAATTTTAAAAATGTGAAATTTTTGATTGTTTACTGTTATTAACCAGTGCC TTTGCCTCCAGCCTGATTCCCTTAAATACAATTTATTTAAGGCAGCAGTAGCAATTTTTT AAAATATAAATATGAAAGTATTACTCCACCTAGGGAATCCATAACTTCCCAAATAAAGTC CAAGCGAAGGTCTTTGTGGCTGGCCCACTCTTATTTCGCCTCCTCTACGCATGCCCTTCA TGGCAGCCAGGTTAAATGACTAGTAATGGCCAAACAGCACACATTATTTCACAAGTCTAT GCATTTACATTAGGATTCCCACTCCCTGGAATACACTGTCATCCTGCTCCACTTGGCTAA CTCCACGCACCTTTCAAACATTAGTTGGAGTCATGTTTCTCAGGAAAACTGCCTCATCCC TCAGTCTGGGCTAGATGGCGCTTCTCTACGATGCCATTGCACACTCACAGTGCTTTACAC CGGCTTATTGGTCTAATGCAGGGCTGTCCAATAGAACTTTCTGCAATAATGGAAATGCTC TATAACTGTGCTATCCTGGTGTTATTAAGCACTTGAAATGTGGCTAATGTGACTGAGGAG CTGAATTTGAAGTTCTATCTAAAAATTAGTGGTCCTGTATTAATAGAACAGCACGGGTCT AGAATGAAGTTCTTGAAAGCAAAGATCTTCTCTCTCCTGAGCCCTGATACAGTGCCTGGC ACATAGTGAAAGCTCAGAGTATTTGATAAATGATTGACTGAATAAATGAATATCTTGCCT ATTATTTAAATAAGGTTGCTAAAATGTCCTATGCTTTAAAAAAATCTCCCTAATTAATTG GAAATAATTTTGGTTAGATAAATATATATTCCAGTAATTATTCATTCAATAACTCTTTAC CAAGTAGGTCCCAGGTGGAAATCTAGTGCTGATTTATCTAGCTCTTTATCCTTAAACAAG ACACTTGATCTCTCTGGAACCCCAATTTATCCTTCTGCAAACAGAGATTTGTGTTACATT TGTAGTTCTAAACTTCTTATGAGACATAAAATTGAATTAAATGCTGTATGCTTTTGCCAG AAATGTTTATATTTAATTAAAAGAGATCCATGGTTCTCCTAAAGTCTATTTAAATTAAGA CTTTCTATACTAGATGAAGCTTGAAGTCCCTTTCAGTTCCAAACTCATACAGTACCATGT GCAAGACATATAGTTGGTATTTACATAGTACCATACGAAATTGACATTTTTGGAAATCAG CAATTATTAAATGTTAGCAATCTTATACAATTAAATCTAATACAATAATAAGAGTATAAA GAAGTCTGAGGACTCAAACTTATGGTTTCAGGTCAATCTGCATATGCTAAAAGAAAAGTA ACTAACCAGAGCACTGTATGGTATACATCAAATAAAGAGATGTCACAGGTAACTCCAGAT TCAGACACATGAGGGGGCATTATGTTCTGCATGAAGGTGGGAACTCAAGGTGAAAGAGGG TAGAATCCAGAGAGATGGGAAGAAAGAGAAGTGCACTTAGGATGAGAGTTCAAGGGGTAG TGATGACCTCAGACCTAGGGACAAAGGTATAATGTATCTTCCTTCTCTCAACTGGAGGAC ATTCACTTTACTTCCGTAGGTTGATCTTTGCAACTATGTCTCTGTCAATGGGGCCACTGC TCACCCCCACATTGAAAATGATGGAACCGTTTACAATATTGGTAATTGCTTTGGAAAAAA TTTTTCAATTGCCTACAACATTGTAAAGATCCCACCACTGCAAGCAGGTGAGTTTACCAA TCTGTCCTCTTCTGAAAATAAGTGTCTATATTGTGAGAAAGTTACTGTATTGTGAGAAAG ATAAGAATGTCAGAATAGCATTTTGTGCATAGTTAAATTACTCTCAGACTTCAGAAGTAC TGCCCTCATCCCTACCCTATAAGGGGCCTAATGCCCAAGGGCATCATATCAAAGGATGAC GACTTGAAAATATAGAAAGCAAGTGTCCAAGTTCTCTTCTAGAATATTAAAAATGTAGTA CATATATATATATGGATTTGATCATATACAATTAGGATTCAAACTTAGCAAACATTTATT GAGCACTTATTCATGTGCTAGGCAAAATTAAATTAAATAAGCATGTATGTGTGCATAATA GCATACATACATATATGAGAGTGTACTAAATATGTTGCGCTTAATTCCCAAAACTACAAA CAAATCTGTTATCTCATAGAAGTACTATAGAAAAAGAACTACAGCAAAAAGAGTGTACCC TAGAATTCTCCATTCATTCTTCATTTATTGCCAGGTTCATTGTTCACCACCTTGATGATG GAATTATTTGAATGTATACAGATTTTTGTTTAGTATTATTTAGTACAGTTCTCAAAGTGT AGTCCTTGGACCAAGACCATCACCTAGGAAACTGTTAGAAATACAAATCTTGAGCCTTGT CCTGGGCAGACTGAATGAGAAATTTTGGGAGTGGAGCCTGCAATCAGTATTTTAAGAAAC TCTTTATGTGATTCTGATGCACACTAAAGTTTGAGGACCATTCACTTACTAGTGAGTAAA TTTTAATGTGCATAAGAATTACTGTACAGGGCTATTGACACAAACCCATCTAAACTATAT CCTTTGGGCATCTTAAGATGTTGCAAAAGGCATTTTGACCATTCTGAGGTTTCTTCCCTA CTCCCCTGACTTAAAACCCACCTCCAGCTATTGCAAGATGTGACTCCACTACACTCCACT TGCCACAACCCTATTTGAGTGCACGTTTCCAAATCTGCTGCTATTTGGATTTTCCTGGGT GATTTTGCAGCTTCACATGAAATTTCACTAAGAAGTGCAAATGATGGAGAAAATGAAAAT AACCCCTCTAAAACAATCAAAATGTGTTTCTTTGCCTGTATAAGCTGTTCTAAATGCTTT GTATTAAAAAAAAAATAAGAGGCTCTTCCAAAGCCTTTTAAAACCACTTTATTTCAGACA AGGAAGATCCAATAAGCAAGTCAGAGATCGTTGTACAATTCCCCTGCAGTGACCGATTCA AGCCATCTTACGTTCATAGGTAACTTGAAGGCCTGCTATGAATCTTCAGGAAAACTCAAG TTTAAAGATTTGCTTTGCCTACCTTTGATACCAATCCTGATCACAATATTTTTTTGCAGA AAACTAAATTTAAACATAATTAATTTCATGTAGGCACTGTTGATTCTTGTAACTGAGCAT ACCACATATATACAAATTTGTCTGTGGCTTGAGAATCAGCCCTTTCATTCACAAGCCCAT TTGTGTTTCTGAACAGTTTTGGTCTGACTCCCAACTATATCGTTTTTGTGGAGACACCAG TCAAAATTAACCTGTTCAAGTTCCTTTCTTCATGGAGTCTTTGGGGAGCCAACTACATGG ATTGTTTTGAGTCCAATGAAACCATGGGGGTAAGTCTTAGATATATTTGTCAAGTTTGTG ATTCTGAAGAAGATGTGTTTAATAATGTACACTTTTTTCCTTTTTAAATGCATCAAAATA TTTTCCTCATTTTTCAAGGTTTGGCTTCATATTGCTGACAAAAAAAGGAAAAAGTACCTC AATAATAAATACAGAACTTCTCCTTTCAACCTCTTCCATCACATCAACACCTATGAAGAC AATGGGTTTCTGATTGTGGATCTCTGCTGCTGGAAAGGGTAAGAAAGGACACTGGACAAA TGGGACACCTCCCATTGTTCCTGGAAATTACGGGGTTTTTACAGAGCTGCTGCACTCAAT CTGAATCACATCTAAAACAGCAAGAGTTATGTGAGAGTCAAAAATGTAATTGGAAAAGCA GTAGGAAGTTTAGGTAATCTGAACATCAAAACTATGATTAATGATTGAAAACTAATCGGG TCCATGAACCCCACCTGAAAACAAAAGATTCTGTGACCTGAGAGGTGAACTTAAAGTTGA CAAAATCCCTGGGGAAACTTGAGCCCCATCTTCTCTGCGAAGGGAGAAAAAGACATGCGT TTTTCAGACTAGCCAAATCACTAAGAAGACAACAGCACCTAAGGACACAAACAGAATGGT GACAGGAAGACAGAACAGAAAGTATCTCAAGGCTGCTGTTACTTAAACAAATCCATTAAG CAGGTTGCTTTATTTTCATCCTGTGTGGGCGGGAGGAAATGGCTCTGATACACCTGGCTC AATAGCAGTTTCTGGGTTGTGGAATAAAGAACAGGCAGGCACTTGTGCTTAAAAAGGCAA GAATCATCTCTCTAAAATTATTTGTCATTGCCTGTGCTCATGTTTGACTTTTTATTTTTG CAGATTTGAGTTTGTTTATAATTACTTATATTTAGCCAATTTACGTGAGAACTGGGAAGA GGTGAAAAAAAATGCCAGAAAGGCTCCCCAACCTGAAGTTAGGAGATATGTACTTCCTTT GAATATTGACAAGGTAACCTGCTTCTCTGTAGATTTCAGATTTAACCAGAATGTTTCATC TCTCTCAGGAATTGTCCTCCTGCCTCATGTTTATACATAAAGTCTTGAAATTTGAGAGCT AGAAGGAGCTTTAAAAATAGGCTAATTAAACTTCCTTCATTTTACAAATGAAACTAAAGC TCAGAAGAGTACTGTGACTTAGCAAAAGCAACTGCAGCAGAGCCAGGATAAGAACCAGGT TTTTAAATTCTAAATCTGCCGTTCTTGTATTTACAAAATTGTCTTTAAAATATACTTCCT CGGTGAATAGTGCAGATCCACTGATTCCTATGATACTTTATCAATAATATAAATAGTTTA AATAATTTGAAGTTCTGGAGAGATGAAGCATCAAAAAGTACTCTTGTAGGGAAACCAGTT CATTATTTTGGTTTTCTATAAATCTTCTGAAAAATATCACTAGAGGTTAAAAATCATTAC TAACAATAGACAGTCATCTCTTTATTTCTACTTTTTCTTCCCTGTATTTAGAGACTGTCT TTTTAGAATAACCAGAGTAACATCTAGAATTTGTAGTGTGATGGAAATACCAGTCAAAAT CAATAAAATATAATTCTCACATATAGGTATGTGAATATATGCTTTCTTTTATATCTATTT GCTCCCTGGTTGCACAAAAGGGGTTATTAAAACAGCTACATGGAATGTAAAACTTTGCAC CAAAGGCTTAGATATGGTGTAGTAGAAAATAAACTCAATTTAGAACCAAACACCACTGCT CTTAAGCAAGTTTGTAAGCTCTATGAAGAATGAGAAAGAGGGAGAAGGTTGAGGTTGAGT GTTACAGACAGGCAAAGGGGCGTCTATAAAGGCAAGGAGGAGTTAAAAATGCAAGATTTC ATCTATAAATATGAAGTAGTTGCTGAGTTTGGTTTATTTAGGGGTGTAGGGGAGATGGGT TTTGGGCAGAGAGACTGGAAAGATAGGTTGGAGCAATATTGTAATGGGCTATATAAGCCT TTGAGTGTTATATAAATATAGGGAGCCATTTAAGTATTTTAAATGTGTATTTTAAGTGTA TTTTAGGACATGATTAGATCTGTGATTCAGAAAGTTACTCTGGCAGCATCATGGAAGACA GACTGGAAAGTGGAGAGTCTAGAGCAGAGGCTAGAAGCCCTATTACAGGATTAATGCAAT GAGGCAAATAAAAGGGAATAAGTAGTTGAGTTAAGAAAATGGTGACTGAGAGATGAAGAT GCAAAGCTGAGAAATATTTAGGCAGCAAAATCAACAGCAGTTGGTATCTAATTACATGTG AGGGGTAAGGGAGAGGAAGGAGTTCAGGATGACTTCAAGATTTCCATCCTGAGCAGTTGA GTGAATGATGGTATAATTCACTGAACTGAAAACATAGAAGTAAGAGGAGCTGGGCCAGGC GCAGTGGCTCACACCTGTAATCCCAGCAGTTTGGGAGGCCGAGGCGGGTGCATCACCCGA GGTTGGGAGTTCAAGACCAGCCTTACCAACATGGAGAAACCTCATCTTTACTAAAAACAC AAAATTAGCTGGGCATGGTGGTGCATGCCTGTAATCCCAGCTACTCAGGAGGCTGAAGCA AGAGAATCGCTTGAACCCAGGAGGCAGAGGTTGCAGTGAGCCGAGATCATGCCATTGCAC TCCAGCCTGGGCAACAAGAGTGAAATTCCATCATAAATAAATAAATAAATAAATAAATAA ATAAATAAATAAATAGAAGTAACAGGAGCTAGCTTGTAGAAAAAAGAATAAATTTTACTT TATAGATGTAATTTGAAAGTACCCACTAGCAATCTTAGCAAAGCATTCCATAGGCAGCTG CTGTACATGGATCTGGAGCTCCAAAGAAAGATCATGGAGAGAGATCAATCTGGGTACCTT AAGGATTTTTGCTTTCCCCTTAAGAAGCATATCACTGACATGTAGTTGAGCATTCCCAAA ATACTCACCAAATGGATGAGTCAGTTAATTTCAGTAAACTCTTACTTCGCTAATAATGGT AAAAATCACAATCATCTTTAAGGAAATAAAAGAGGATCACTTAACTTAAATATTCACATT GCAAAATAAAGAAAAAAGAAGGATTTTTCTAACTGTATGGTTATCACGGCCTGAAGAAAT ATTACCCAATTATAGAATAGGGAACTGTAATAATCATAAAAAATGTCTAACATCATCAAA TCCGTCTCCTCTTTCTTCTAATAGTTATTGAGTAGCCACTAAAACAGGCATCATACTATT TGTTGCAGTGGGTACATAAAATACACTTCTAGTTCTCATGGAGCCCGTTACCTAGTGTAT CAGAGAGAAAGAAGCCGAATCAGGAATAGCCATGCATGTCAGCACAGGAGTAGTACTCTC AGGAGGGATAAATTGATTTGTTAATAGCTAGTCAGATGATAATGTAGGGGAGATTAATGG AACATAGTTATTTGCAATGGGCAGTAATATGGCAGGTGGAGATGGGATTGAGGCAGAACA ACTGAAGACAGAAAGAACAGTTTGAGGAAAGACAGATAGGTGGAGAGGGAGATACGCAGA GAGAATTGGCTATTATAATTGGTTGAAACATAGGCAAAAGTAGTAAAGTAAATGGGATAA AAAGTTATAAAAGTACGTTGTACTCTTAGAAGGCTTTAAGGCCAGGCTAAGAAATTTGCA CTTTATTGAACTGGTAATGGAAAGACAGTGAAGGTTTTTACACAAAAGAAAAGCCCATAA TTAATGGTATTGAAATGATAATGAAATATGTAAGAATAGAGAGATAAGACTGCAGGCAGG GGGGGAAATCATATTTTAGATTAGGTTTTCCAAAAGAAACATTTAAAATTTGCTTATTTA AAAAATAAAGAATTTGAGAGCCAGAGAATACAGAGAGAGAAGACAGCCAAGCACAGTAGC TCCAGAAAATAAACATGTGTAGAAAATGGTAGAAACAAGAGAAGCCAGAAAAAGAAACAA GAGAAGCCAGAAAAAGAAACAAGAGCCACCAGAAAGCCCTAGTTCCTACTAAGAGAGAGT AACGTCACAAAGATGAGTGCAGGTGAGGGTTATACGGTGCCCATTGCCATAGACAAGTTG AAAAGGGTGAAGACTAAGAATAAAGCACTAGGTTTGGTGATCTCTAAGGGAATAGAGTGA GAGAGACAGAAGTCAGGCTTCAGGGCTCTTAAGGTAAGCAGTTGAGTATCTGGAAAGCAG TTACTGCGTGCACACTCTTAAAAGTTTGGCAATGAAGAGAAAAATAGAAAGGGCTTAGGT CCCAGTTACTTGGAAGACTGAGGCAGGAGGATTGCTTGAGTCCAGGAGTTCAAAGTTACA GTGAGCTACATGCCATTGCAGTCCAGCCTGAGGAAAAGAACAAGACCCCATCTCAACAAA CAAACAAACAAAACAGAACAAGACTCCATCTCAAGAAACAAACAAACAAACAAACAAACA GGAAATCTAATTTAACAATGAAAATAAGCAAAATAGAACAAAGTAAAAAATTCAACTTGA AACCACATAAATAATATATTAAACATAGACATAGACATTTGTACTTATTGTATGCATGTA CATAAATATGCATACATGTGCACACCCCTCGCTTCTTCCCAGCATCACCACTAAGTACCT CGAGTCCCTTATTTCACAAAATCTTGCAGAATCTTCTCCTCTATTGGCTCCCACCTCCCA TCCTTTCCCTATTCTGAAAATCTTCCACTATTTACTTTTAATTCTTAGTCCACCACCAGA AAAAATCTCCTGTCTTCTCTTCTTAGAATGTTGCCTTCAACCTCCTTTTTTAACCAAAAT CTGGCTCTCTCCCCTAAGGACACTGGTCTCCCCAACAGTAATTTCCAGGGGAATCAGTTT CTCCTCTGTACAGGGTACAGCCCTTTTACCACTTGGCCTGGAGTTGGGGTAGAGGTCCTT CTTCTTTGCTGCTTTCAGATCATTGTTCCCTCTATTCACCCTTAAAATTCCCTAAGTTTT CATCTCATTTTATCTAATCATATAGCCAAGTGATGTATATGTGTGTGTGTGTGTGTGTGT GTGTATATATATATATATATATATATATCCCTCATGCCCTCGACTTTGCCACTACTTAAG ACTATACTCCTTCCATAATCTGTTTCATGCATGACCCACTCTGACCTTTTATCTTTCAAC ATCACTTGCCCTACTGCAATTTCCACCAGGAACTTCCAATCCATTGAACACAGTACTTTC TCACTCTCTCTCACTACGTTGAGGATTTACCTTCTCTCCTCACTCAATTTAAGCTTTACA GTCAATAATTACAAACACTTTCTCATGTAGACCTTCCTTTCCCTTGCCTCTTTCTTACCT TATCAAAGTCATTTGTCAAAATCACAACCCTAGTTAAATTCAGCTCTCCACCCCCTCCAT GCTTATACCTCTGAGGCTGAACTAAGTGCAGACAACACACAATCATGTTAATTGGTTCCA TTTTAGATGCATGACCACAAATCTTTCTGCTACATTTCCCGGCTTCACTTACTCTCTCAC TTTGCTAGTTAAATATTCCACACCCTCCTCTCTTTAAACTTTTACCACCTCCCACTTCCC GCCTCCACACTCAGATGCAGCTGATGGCTATGTTTTCTTTTTCTCTGAAACAAATGAAAG AAATCAGAAAGGAACCATAGACTTGCCAGCACATCTACCCACCCACCAGCATCTGTACTC ATATACTGAATTATCCATCTTCCTATCCAGAGCTGATCTCTTTCATCCTCCTTCACATTC TCAGGGAAATCACTCTCCCAATTCTCCCCATCTTTCCTAGATCACCACTCTCCTACCCTT TTCGATGGATCATTTTTGTCAGGCTCTTACAAAATCCTTCTCTTGACATTTTTGCCCCAA CCAGCTACCTTCTCATTCCTCGTCTTGTTGGAGGGCCTTGGTTCCCCTATCTTCCATTTA TACACTCACTCGTTGTTAAATATTCATGCCTTATTCATTTACATTTTTAGCTTTCTCTTA AACTCAAGGTTCTTACCTGCTAGCGCCAGCTCCACATCTGCATTTGGATGCCCAATAGAC ATCTCAAGTCTAATAAGACAAGACTTGAACTTCTCATCTTCCCCCACCAAAAATTTACTC CACCTGTAGTTCCTATCTTTGTTGTGACATCAACATTGTACAGGTCAAACACCTTGGTGT TATGCTTGATGCCTCTCTTACTTTCATGCCTCTTCCTCGTCCCATATCCTATTTAACAGG AAATCTTCTTGACTCTGTCCTCCACTTCTTCCACTTCTCACTGACTGCAATGCTACTGGC CTAGTGTGAACCATTGTTTTCTTTCAACTAGACTACTACAAGACAAACTGGTTTCCCTGA TTCCACTCTTGGATCCTCCCTACTAACAAGGCTACCCTAAAAATAAATCATAGCATCTCA CTCCTGTGCTGAAAACCCTCCAATGGCTTCCCATCACTCACTCACAGAGAAAGATCAAGT CCTCATAATGACCTACGAGGCTTTGTACAGCCTGGCTCGTGACCTCCCCACCTTCCTTTC TTATTCTCTCCCCTAGCTCAGTTGATAGAATCCACACTGGACTCTTTGATGCTCCTCAAA CACACTCAGCATCCTCCTCCCTCAGGCCTTTGCACAATTTGTTCTCTTAGCGTGAACACT CTTCCCCAGATATCTGCATTGCTAATTCTCTCATCTTCTAAGAGTTTTGTCTCCTCTGCC ACCTGTTCAAAGAGACCTACCCGAACCATCTATTCAAATTTTAACCGCTTACCCTTCACG TTTCTGATCTTTTTTCCTCTATTCTATTTTTCCCCCACATTTGTGGTATATTATAAAATT TATTAATTATATTTATTGTATATCTCCTTGAACTAGAATGTAGGCTTCATGAGGACAGGG ACTTCACTCTCCAAAACATCCTGAATGCCAAGAATAGAGTCTAGAATAAAATATGTAATC AAGTATTTGATGAAATTATTAATAAGTAGATATGTTAGAAAAATCTCATGGTATTTCATA AAATAATCAGAAAAATCATGTGTGTGTGACAAGAGATCTTAGGAAACATATGGTCCAGCG TTTTTTTTTTTTCTTTTTGTCAACATAACTGTAAGGATTTTTTTTTTCAAGCAAAATCAA AACATATTCTACGTGTGAACGAAATATACATTCTTTCATCCCTCAGGCAGTCGAAGTCTT TGTTGTTCTGCAGAAAAACATTAATTATTATTATTATTGGTTTTGAGATTTTTGTTTGGT TTTTGTTTTTTTGTTTTTCAGAGGCCTTTCTTTGGAGCCCTAAATTTTCTTCAAGGATGG TCTCATTTTACTGAAGAGAAAATTGATGGCCTAAGAGGTTATGTGACTTTCCCAGTGATA CATAGCCAGTGACTGACACAGGCACAGATAGCTTGCCCAGTCGCGTCCCAGGGTCCCTCA TCTATAGCTTCCTGCAGTTCCTCCCTGCATGTTGACCTAAAAAAGAACTTAGGAGCCAAG ACTTAAGAACTCTGCATTTCTGGCTGTTTGAATTCTTTCCTGCTCACTGAGGTTTCTGTT ATCTTCTCTCCTAGGCTGACACAGGCAAGAATTTAGTCACGCTCCCCAATACAACTGCCA CTGCAATTCTGTGCAGTGACGAGACTATCTGGCTGGAGCCTGAAGTTCTCTTTTCAGGGC CTCGTCAAGGTGAGATGATCTAGAGAAAACTTCACACGGGAGTGAACAAATGTTTCTTTC AAAGAGATTAAGAGTTTTCCTAAGCATGTGCTCTATTTCGTAGCATTTGAGTTTCCTCAA ATCAATTACCAGAAGTATTGTGGGAAACCTTACACATATGCGTATGGACTTGGCTTGAAT CACTTTGTTCCAGATAGGGTAATTAATCCTTCTTACTAATATTTGAACAGTGCTTTGAGT ATATGCTAGTCAAGTAAAGCATATTGACTGATTGCTTGATTGATTTTTCTTTCTCACAAA CAGCTCTGTAAGCTGAATGTCAAAACTAAAGAAACTTGGGTTTGGCAAGAGCCTGATTCA TACCCATCAGAACCCATCTTTGTTTCTCACCCAGATGCCTTGGAAGAAGATGATGGTAAT GAAAGCAATTGTTGTGTCTGAATACTCTTCTTACTGCAGTTCTGTATGTTAGTTCGTTAG GAAAGGAGTAAGGTTGATTATTCCGTAATACTCAAAAACGATCCTTAATACTATAAATAG AGCAGTACTGAAGAATTAAAACTATTTGAAAAGAATTTTCATCTTTTGATCAGGTCTTGT TGATTACCAGTAGAAAAAAATGTCAAAGCACCATTTGGTGTCACGATGGAGCATCAATGT CTGCTCTAGATGAGGGAGAGAAGGAAGAAAAAATGGCAACATGAATTCCAGGTTTTTGCC TTCCCTGACGAAGACATATTTCTAAAAAAATAGCAATTCTAAGAAGGGAAGCTAAGTATT ATAGCAGATACAAGAGAATGAGAAGGCAGGTCTGTGAATAGTTTTCATTTGTTCTTTCGG TAAGCTAGGGCTTGAAAAAAGACCCAGAGCCACACCAGCAACTCAGATACAGCAACTCAA ATTACAAATCAGCAGTGTTAGTTAACTGCTTCTCAGCTGGGACAGGGAGATAGATTACAC TCTATGGGATTAAAATATGGAAAACTAAGAGAAATGAGATAAAGAATTGTGGAGCCATTT CACACTAAATGATTTTATATATCCAGTCGAAGCTGTAAAAGATTTGTTCTCATTTTGTTC GAAGGAAGTCAGCTTCCAGATCGATCTTAGAAACCATACATATGATATATCTTACTGCTT TCAAAGTCTTTTAATACACACTTTTCATGTGATCATCACAGTTTTTACAGTATGTACAGC AGGTGCTATATTTGTATGTTACAGATAAGAACAGATCCATTTATTCAGTGAGTATTTAAT GAGTACCTACTACGCTGTAGTCATTGTCATAGAATATTGAGATATAGCAGTGAGCAAGAC AGACAAGACTCTCCCTTCTTAGAGCTTACAGTGTAGGTAGGGTACATAAAGAGTTTAAAA GACCTCTTTAGGTGGTCTCATGCCAGGTGGTACAAGAGTCAGAAAAAGAAGTCAGGTCAT ATGGTTTTCTATATTTGTCAATGTAATACCTCCTATATTATTTCAATGACATTCAATCTA TAGCTTGGGCTTTTAAAAACTCAATATTGCCTAATTTACTTCTGATAAACAGGTGTAGTT CTGAGTGTGGTGGTGAGCCCAGGAGCAGGACAAAAGCCTGCTTATCTCCTGATTCTGAAT GCCAAGGACTTAAGTGAAGTTGCCCGGGCTGAAGTGGAGATTAACATCCCTGTCACCTTT CATGGACTGTTCAAAAAATCTTGAGCATACTCCAGCAAGATATGTTTTTGGTAGCAAAAC TGAGAAAATCAGCTTCAGGTCTGCAATCAAATTCTGTTCAATTTTAGCCTGCTATATGTC ATGGTTTTAACTTGCAGATGCGCACAATTTTGCAATGTTTTACAGAAAGCACTGAGTTGA GCAAGCAATTCCTTTATTTAAAAAAAAAAGTACGTATTTAGATAATCATACTTCCTCTGT GAGACAGGCCATAACTGAAAAACTCTTAAATATTTAGCAATCAAATAGGAAATGAATGTG GACTTACTAAATGGCTTTTAATTCCTATTATAAGAGCATATTTTAGGTACCTATCTGCTC CAATTATATTTTTAACATTTAAAAACCAAAGTCCTCTACACTTGATTTATATTATATGTG GCTTTGCTGAGTCAAGGAAGTATCATGCAATAAGGCTTAATTACTAAATGTCAAACCAAA CTTTTTCTCAAACCAGGGACTATCATCTAAGATTAATTACAGTAATTATTTTGCGTATAC GTAACTGCTCAAAGATTATGAATCTTATGAATGTTAACCTTTCCGTTTATTACAAGCAAG TACTATTATTTCTGATTTTATAATAAGAAAATCTGTGTTTAATCAACTGAGGCCTCTCAA CCAAATAACATCTCAGAGATTAAGTTATATATTAAAAGCTTATGTAACATAAAAGCAAGT ACATATAGTAGTGACTATATTTAAAAAAACAGCATAAAATGCTTAAAAATGTAATATTTA CTAAAATCAGATTATGGGATAATGTTGCAGGATTATACTTTATTGCATCTTTTTTGTTTA ATTGTATTTAAGCATTGTGCAATCACTTGGGAAAAATATTAAATTATTAACATTGAGGTA TTAATACATTTTAAGCCTTTTGTTTTTAAATTTCTTTTCTTCCAGAGATTGTTTAAAAAT AAATATTGACAAAAAT OMIM ID 180069