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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for PTPRK (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID5796
Official gene symbolPTPRK
Full nameprotein tyrosine phosphatase, receptor type, K
Aliases,DKFZp686C2268,DKFZp779N1045,R-PTP-kappa,
Gene summaryThe protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP was shown to mediate homophilic intercellular interaction, possibly through the interaction with beta- and gamma-catenin at adherens junctions. Expression of this gene was found to be stimulated by TGF-beta 1, which may be important for the inhibition of keratinocyte proliferation. [provided by RefSeq]
LocationChromosome: 6   Locus: 6q22.2-q22.3
Gene position128841870 - 128289924  Map Viewer
Gene orientationminus
Gene size551947 bp
Gene sequence
OMIM ID602545