| Entrez gene ID | | 5796 |
| Official gene symbol | | PTPRK |
| Full name | | protein tyrosine phosphatase, receptor type, K |
| Aliases | | ,DKFZp686C2268,DKFZp779N1045,R-PTP-kappa, |
| Gene summary | | The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP was shown to mediate homophilic intercellular interaction, possibly through the interaction with beta- and gamma-catenin at adherens junctions. Expression of this gene was found to be stimulated by TGF-beta 1, which may be important for the inhibition of keratinocyte proliferation. [provided by RefSeq] |
| Location | | Chromosome: 6 Locus: 6q22.2-q22.3 |
| Gene position | | 128841870 - 128289924 Map Viewer |
| Gene orientation | | minus |
| Gene size | | 551947 bp |
| Gene sequence |
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| OMIM ID | | 602545 |
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