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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for PTPRJ (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID5795
Official gene symbolPTPRJ
Full nameprotein tyrosine phosphatase, receptor type, J
Aliases,CD148,DEP1,HPTPeta,R-PTP-ETA,SCC1,
Gene summaryThe protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes, including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region containing five fibronectin type III repeats, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. This protein is present in all hematopoietic lineages, and was shown to negatively regulate T cell receptor signaling possibly through interfering with the phosphorylation of Phospholipase C Gamma 1 and Linker for Activation of T Cells. This protein can also dephosphorylate the PDGF beta receptor, and may be involved in UV-induced signal transduction. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
LocationChromosome: 11   Locus: 11p11.2
Gene position48002110 - 48192394  Map Viewer
Gene orientationplus
Gene size190285 bp
Gene sequence
OMIM ID600925