| Entrez gene ID | | 5795 |
| Official gene symbol | | PTPRJ |
| Full name | | protein tyrosine phosphatase, receptor type, J |
| Aliases | | ,CD148,DEP1,HPTPeta,R-PTP-ETA,SCC1, |
| Gene summary | | The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes, including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region containing five fibronectin type III repeats, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. This protein is present in all hematopoietic lineages, and was shown to negatively regulate T cell receptor signaling possibly through interfering with the phosphorylation of Phospholipase C Gamma 1 and Linker for Activation of T Cells. This protein can also dephosphorylate the PDGF beta receptor, and may be involved in UV-induced signal transduction. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] |
| Location | | Chromosome: 11 Locus: 11p11.2 |
| Gene position | | 48002110 - 48192394 Map Viewer |
| Gene orientation | | plus |
| Gene size | | 190285 bp |
| Gene sequence |
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| OMIM ID | | 600925 |
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