| Entrez gene ID | | 5792 |
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| Official gene symbol | | PTPRF |
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| Full name | | protein tyrosine phosphatase, receptor type, F |
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| Aliases | | ,FLJ43335,FLJ45062,FLJ45567,LAR, |
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| Gene summary | | The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains three Ig-like domains, and nine non-Ig like domains similar to that of neural-cell adhesion molecule. This PTP was shown to function in the regulation of epithelial cell-cell contacts at adherents junctions, as well as in the control of beta-catenin signaling. An increased expression level of this protein was found in the insulin-responsive tissue of obese, insulin-resistant individuals, and may contribute to the pathogenesis of insulin resistance. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq] |
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| Location | | Chromosome: 1 Locus: 1p34 |
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| Gene position | | 43996547 - 44089343 Map Viewer |
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| Gene orientation | | plus |
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| Gene size | | 92797 bp |
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| Gene sequence |
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| OMIM ID | | 179590 |
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