| Entrez gene ID | | 5688 |
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| Official gene symbol | | PSMA7 |
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| Full name | | proteasome (prosome, macropain) subunit, alpha type, 7 |
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| Aliases | | ,C6,HSPC,MGC3755,RC6-1,XAPC7, |
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| Gene summary | | The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. This particular subunit has been shown to interact specifically with the hepatitis B virus X protein, a protein critical to viral replication. In addition, this subunit is involved in regulating hepatitis virus C internal ribosome entry site (IRES) activity, an activity essential for viral replication. This core alpha subunit is also involved in regulating the hypoxia-inducible factor-1alpha, a transcription factor important for cellular responses to oxygen tension. Multiple isoforms of this subunit arising from alternative splicing may exist but alternative transcripts for only two isoforms have been defined. A pseudogene has been identified on chromosome 9. [provided by RefSeq] |
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| Location | | Chromosome: 20 Locus: 20q13.33 |
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| Gene position | | 60718474 - 60711791 Map Viewer |
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| Gene orientation | | minus |
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| Gene size | | 6684 bp |
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| Gene sequence |
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| OMIM ID | | 606607 |
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